Thursday, July 15, 2021

Friday Thinking 16 July, 2021

Friday Thinking is a humble curation of my foraging in the digital environment. Choices are based on my own curiosity and that suggest we are in the midst of a change in the conditions of change - a phase-transition. That tomorrow will be radically unlike yesterday.

Many thanks to those who enjoy this.
In the 21st Century curiosity is what skills the cat -
for life of skillful means .
Jobs are dying - Work is just beginning.
Work that engages our whole self becomes play that works.

The emerging world-of-connected-everything - digital environment - 
computational ecology - 
may still require humans as the consciousness of its own existence. 

To see red - is to know other colors - without the ground of others - there is no figure - differences that make a defference.  

‘There are times, ‘when I catch myself believing there is something which is separate from something else.’

“I'm not failing - I'm Learning"
Quellcrist Falconer - Altered Carbon





It’s becoming clear that ecosystems and organisms rely on viruses. Tiny but mighty, they have fuelled evolution for millions of years by shuttling genes between hosts. In the oceans, they slice open microorganisms, spilling their contents into the sea and flooding the food web with nutrients. “Without viruses,” says Curtis Suttle, a virologist at the University of British Columbia in Vancouver, Canada, “we would not be alive.”

There are minuscule circoviruses with only two or three genes, and massive mimiviruses that are bigger than some bacteria and carry hundreds of genes. There are lunar-lander-looking phage that infect bacteria and, of course, the killer spiky balls the world is now painfully familiar with. There are viruses that store their genes as DNA, and others that use RNA; there’s even a phage that uses an alternative genetic alphabet, replacing the chemical base A in the standard ACGT system with a different molecule, designated Z.

...many scientists’ suspicion that there’s no one common ancestor for virus-kind. “There is no single root for all viruses,” says Koonin. “It simply does not exist.” That means that viruses probably arose several times in the history of life on Earth — and there’s no reason to think such emergence can’t happen again. “The de novo origin of new viruses, it’s still ongoing,” says Mart Krupovic, a virologist at the Pasteur Institute in Paris who was involved in both the ICTV decisions and Koonin’s taxonomy team.

Viruses can also influence other organisms by stirring up their genomes. For example, when viruses transfer antibiotic-resistance genes from one bacterium to another, drug-resistant strains can take over. Over time, this kind of transfer can create major evolutionary shifts in a population, says Camarillo-Guerrero. And not just in bacteria — an estimated 8% of human DNA is of viral origin. For example, our mammalian ancestors acquired a gene essential for placental development from a virus.

Beyond coronavirus: the virus discoveries transforming biology





Anil Seth enumerates five different kinds of self-models: bodily, perspectival, volitional, narrative and social selves. These selves are not orthogonal and perhaps partially ordered in what is a prerequisite over another. In his essay “The Real Problem”:

There is the bodily self, which is the experience of being a body and of having a particular body. There is the perspectival self, which is the experience of perceiving the world from a particular first-person point of view. The volitional self involves experiences of intention and of agency — of urges to do this or that, and of being the causes of things that happen. At higher levels, we encounter narrative and social selves.

all the world models involve the inclusion of self-models. These self-modes are all ‘Inside Out’ architectures. To understand compositionality, an agent needs an intuitive understanding of the body. To predict physics requires an intuitive awareness of where and what direction one is looking at when one makes an observation. To understand how to learn, one needs to know how to interact with the world.. To understand causality, one needs the capability of following stories. To understand psychology, one needs an understanding of oneself. In summary, you cannot develop any of the skills that Brendan Lake describes without a previous grounding with a model of the self. Self-models are a necessary requirement for the stepping stones of AGI [Artificial General Intelligence].

I find it more informative to frame consciousness in terms of self-models. The reason for this is that living things are primarily driven by homeostasis. Antonio Damasio in “The Strange Order of Things” argues that the brain’s function at its core is driven by homeostasis. Damasio writes:

Feelings are the mental expressions of homeostasis, acting under the cover of feeling, is the functional thread that links early life-forms to the extraordinary partnership of bodies and nervous systems.

It ensures that life is regulated within a range that is not just compatible with survival but also conducive to flourishing.

Homeostasis and a Definition of Intelligence





To understand physics you need to invent a lot of new languages (see: calculus for Newton). It should be no surprise that understanding cognition requires the invention of a new language.

The problem with our natural language is that it is noun-centric. Unfortunately, all of reality is process-centric. Thus, when we stick exclusively to a noun-centric language, we cannot properly map the complexity of reality.

The Mass Appeal of Reductionist Metaphors





It is a truism of technological progress that whatever can be automated will be - of course there will always be lots of work to do and activity to engage in. But this is a great signal for how things that we didn’t imagine being automated can be.

AI Designs Quantum Physics Experiments Beyond What Any Human Has Conceived

Originally built to speed up calculations, a machine-learning system is now making shocking progress at the frontiers of experimental quantum physics
Quantum physicist Mario Krenn remembers sitting in a café in Vienna in early 2016, poring over computer printouts, trying to make sense of what MELVIN had found. MELVIN was a machine-learning algorithm Krenn had built, a kind of artificial intelligence. Its job was to mix and match the building blocks of standard quantum experiments and find solutions to new problems. And it did find many interesting ones. But there was one that made no sense.

“The first thing I thought was, ‘My program has a bug, because the solution cannot exist,’” Krenn says. MELVIN had seemingly solved the problem of creating highly complex entangled states involving multiple photons. Krenn, Anton Zeilinger of the University of Vienna and their colleagues had not explicitly provided MELVIN the rules needed to generate such complex states, yet it had found a way. Eventually, he realized that the algorithm had rediscovered a type of experimental arrangement that had been devised in the early 1990s. But those experiments had been much simpler. MELVIN had cracked a far more complex puzzle.

Their latest effort, an AI called THESEUS, has upped the ante: it is orders of magnitude faster than MELVIN, and humans can readily parse its output. While it would take Krenn and his colleagues days or even weeks to understand MELVIN’s meanderings, they can almost immediately figure out what THESEUS is saying.


A fascinating signal for how affordances can enable something very useful from innovation aimed at imaginary possibilities.

How Hans Berger’s quest for telepathy spurred modern brain science

Instead of finding long-range signals, he invented EEG

A brush with death led Hans Berger to invent a machine that could eavesdrop on the brain.

In 1893, when he was 19, Berger fell off his horse during maneuvers training with the German military and was nearly trampled. On that same day, his sister, far away, got a bad feeling about Hans. She talked her father into sending a telegram asking if everything was all right.

To young Berger, this eerie timing was no coincidence: It was a case of “spontaneous telepathy,” he later wrote. Hans was convinced that he had transmitted his thoughts of mortal fear to his sister — somehow.

So he decided to study psychiatry, beginning a quest to uncover how thoughts could travel between people. Chasing after a scientific basis for telepathy was a dead end, of course. But in the attempt, Berger ended up making a key contribution to modern medicine and science: He invented the electroencephalogram, or EEG, a device that could read the brain’s electrical activity.

Berger’s machine, first used successfully in 1924, produced a readout of squiggles that represented the electricity created by collections of firing nerve cells in the brain.


This is a signal of the emerging understanding that life itself has been playing around with DNA.
“Here was this wonderful validation that right under our noses, nature has been expanding,”
“It really speaks to the adaptability of the genetic alphabet,”
Z and other modified DNA bases seem to have evolved to help viruses evade the defenses with which bacteria degrade foreign genetic material. 

DNA Has Four Bases. Some Viruses Swap in a Fifth.

The DNA of some viruses doesn’t use the same four nucleotide bases found in all other life. New work shows how this exception is possible and hints that it could be more common than we think.
All life on Earth rests on the same foundation: a four-letter genetic alphabet spelling out a repertoire of three-letter words that specify 20 amino acids. These basic building blocks — the components of DNA and their molecular interpreters — lie at biology’s core. “It’s hard to imagine something more fundamental,” said Floyd Romesberg, a synthetic biologist at the pharmaceutical company Sanofi.

Yet life’s foundational biochemistry can be full of surprises. A few decades ago, researchers found viruses that had swapped one of the four bases in their DNA for a novel fifth one. Now, in a trio of papers published in Science in April, three teams have identified dozens of other viruses that make this substitution, as well as the mechanisms that make it possible. The discoveries raise the thought-provoking possibility that this kind of fundamental genomic change could be much more widespread and important in biology than anyone imagined.

The scientists have now reported finding the Z substitution in more than 200 phages. Further analysis of the viral genomes allowed the research groups to uncover a key enzyme for making Z, as well as an enzyme that degrades free-floating A nucleotides, making Z more likely to be taken up during DNA synthesis.


There was a significant debate during the early years of the theory of Evolution between Darwin and Lamark concerning whether acquired characteristic (e.g. big muscles) could be passed from acquiring parent to children - in recent decades we’ve learned about the working of epigenetics. This is an interesting signal about our progress in understanding epigenetics.
In the new study, Jose and his team found while breeding nematode worms that some matings led to epigenetic changes in offspring that continued to be passed down through as many generations as the scientists continued to breed them. This discovery will enable scientists to explore how epigenetic changes are passed to future generations and what characteristics make genes susceptible to permanent epigenetic changes.

Match matters: The right combination of parents can turn a gene off indefinitely

Evidence suggests that what happens in one generation—diet, toxin exposure, trauma, fear—can have lasting effects on future generations. Scientists believe these effects result from epigenetic changes that occur in response to the environment and turn genes on or off without altering the genome or DNA sequence.

But how these changes are passed down through generations has not been understood, in part, because scientists have not had a simple way to study the phenomenon. A new study by researchers at the University of Maryland provides a potential tool for unraveling the mystery of how experiences can cause inheritable changes to an animal's biology. By mating nematode worms, they produced permanent epigenetic changes that lasted for more than 300 generations. The research was published on July 9, 2021, in the journal Nature Communications.

"There's a lot of interest in heritable epigenetics," said Antony Jose, associate professor of cell biology and molecular genetics at UMD and senior author of the study. "But getting clear answers is difficult. For instance, if I'm on some diet today, how does that affect my children and grandchildren and so on? No one knows, because so many different variables are involved. But we've found this very simple method, through mating, to turn off a single gene for multiple generations. And that gives us a huge opportunity to study how these stable epigenetic changes occur."


Who knows when quantum computing will emerge as a viable alternate computational paradigm? This is a small signal of progress.
 it is the combination of system's unprecedented size and programmability that puts it at the cutting edge of the race for a quantum computer, which harnesses the mysterious properties of matter at extremely small scales to greatly advance processing power.
"The number of quantum states that are possible with only 256 qubits exceeds the number of atoms in the solar system,"

Team develops quantum simulator with 256 qubits, largest of its kind ever created

A team of physicists from the Harvard-MIT Center for Ultracold Atoms and other universities has developed a special type of quantum computer known as a programmable quantum simulator capable of operating with 256 quantum bits, or "qubits."

The system marks a major step toward building large-scale quantum machines that could be used to shed light on a host of complex quantum processes and eventually help bring about real-world breakthroughs in material science, communication technologies, finance, and many other fields, overcoming research hurdles that are beyond the capabilities of even the fastest supercomputers today. Qubits are the fundamental building blocks on which quantum computers run and the source of their massive processing power.

"This moves the field into a new domain where no one has ever been to thus far," said Mikhail Lukin, the George Vasmer Leverett Professor of Physics, co-director of the Harvard Quantum Initiative, and one of the senior authors of the study published today in the journal Nature. "We are entering a completely new part of the quantum world."


A good small signal of new agricultural processes that are more ecological.

New production method makes vital fertilizer element in a more sustainable way

Urea is a critical element found in everything from fertilizers to skin care products. Large-scale production of urea, which is naturally a product of human urine, is a massive undertaking, making up about 2% of global energy use and emissions today.

For decades, scientists and engineers have sought to make this process more energy efficient as demand for fertilizer grows with increased population. An international research team that includes scientists and engineers from The University of Texas at Austin has devised a new method for making urea that is more environmentally friendly than today's process and produces enough to be competitive with energy-intensive industrial methods.

Making urea today involves a two-step thermal process that requires high levels of heat and pressure under controlled harsh environments. But this new process requires just one step and relies on a concept called electrocatalysis that uses electricity—and potentially sunlight—to trigger chemical reactions in a solution at room temperature in ambient conditions.

"Around the world we need to lower emissions. That's why we want to develop these more sustainable pathways to produce urea using electrocatalysis instead of this energy-intensive two-step process," said Guihua Yu, an associate professor of materials science in the Cockrell School of Engineering's Walker Department of Mechanical Engineering who co-led the team that published a new milestone paper about the process in Nature Sustainability.


It seems like a couple of decades have passed since the ‘hydrogen economy’ was a salient buzz in the news. But significant progress towards the use of hydrogen for renewable energy and maybe especially energy storage has continued.

World's biggest green hydrogen hub announced for Western Australia

Western Australia could soon be home to the world's biggest green hydrogen project. The Western Green Energy Hub (WGEH) wants to deploy 50 GW of solar and wind generation to produce up to 3.5 million tons of green hydrogen or 20 million tons of ammonia a year.

This monster project edges out the 45-GW Svevind project in Kazakhstan that was announced just a couple of weeks ago. It underscores the huge paydays the energy industry is foreseeing in green energy exports.

Yes, hydrogen is inefficient and borderline wasteful compared to storing and releasing green energy in batteries. But the world is aiming to decarbonize completely by 2050, and batteries simply don't have the energy density for many applications, such as long-haul trucking, shipping and aviation. Hydrogen will also be key in decarbonizing steel production – and it represents and energy export opportunity in a post-coal and oil world that doesn't look like it's getting a global energy grid any time soon to share renewable power without putting it on boats.

The new hub would take advantage of Western Australia's excellent solar potential and solid wind potential, occupying some 15,000 square kilometers (5,800 sq mi) of largely red, rocky desert near Kalgoorlie in the south-east of the state. Construction would be in phases, to ramp up as expected demand for these green fuels grows.


Not to be outdone but here’s what a small, very advanced country is up to.

Singapore unveils one of world's biggest floating solar farms

Singapore Wednesday unveiled one of the world's biggest floating solar power farms, covering an area the size of 45 football pitches, as part of the city-state's push to cut greenhouse gas emissions.

The project is the country's most ambitious yet, comprising 122,000 panels on Tengeh Reservoir that will produce enough electricity to run its five water treatment plants.

Singapore is among the biggest per capita carbon dioxide emitters in Asia and its land scarcity makes boosting renewable energy sources a challenge.

The prosperous financial hub has turned to setting up plants off its coasts and in reservoirs, and aims to quadruple solar energy production by 2025.

The new farm can produce up to 60 megawatts of electricity, and will lead to carbon emissions reductions equivalent to removing 7,000 cars from roads, according to Sembcorp Industries and national water agency PUB.


A weak signal - that any and every technology can be weaponized. This has glimpses of quite a few speculative fiction scenarios - but this intended use is pretty cool too - what could go wrong?

Swarm of autonomous tiny drones can localize gas leaks

When there is a gas leak in a large building or at an industrial site, human firefighters currently need to go in with gas sensing instruments. Finding the gas leak may take considerable time, while they are risking their lives. Researchers from TU Delft (the Netherlands), University of Barcelona, and Harvard University have now developed the first swarm of tiny—and hence very safe—drones that can autonomously detect and localize gas sources in cluttered indoor environments.

The main challenge the researchers needed to solve was to design the Artificial Intelligence for this complex task that would fit in the tight computational and memory constraints of the tiny drones. They solved this challenge by means of bio-inspired navigation and search strategies. The scientific article has now been made public on the ArXiv article server, and it will be presented at the renowned IROS robotics conference later this year. The work forms an important step in the intelligence of small robots and will allow finding gas leaks more efficiently and without the risk of human lives in real-world environments.



#micropoem



these old movies - 
i get a deja vu -
with so many of them 
 yet i’m sure i never -
had a chance to see them 
weird - 
we-aired - 
we-erred - 
we-ared - 
we-eared - 
we-were’d - 
we-were-d - 
we---- 


we are -
death-walkers -

 i am feeling -
grateful in this moment - 
this space-flight of a life - 
from mystery to mystery - 


Pondering the effort - 
mhm - 
the sadness -
of always an imagining - 
so randomly actual - 

Thursday, July 8, 2021

Friday Thinking 9 July, 2021

Friday Thinking is a humble curation of my foraging in the digital environment. Choices are based on my own curiosity and that suggest we are in the midst of a change in the conditions of change - a phase-transition. That tomorrow will be radically unlike yesterday.

Many thanks to those who enjoy this.
In the 21st Century curiosity is what skills the cat -
for life of skillful means .
Jobs are dying - Work is just beginning.
Work that engages our whole self becomes play that works.

The emerging world-of-connected-everything - digital environment - 
computational ecology - 
may still require humans as the consciousness of its own existence. 

To see red - is to know other colors - without the ground of others - there is no figure - differences that make a defference.  

‘There are times, ‘when I catch myself believing there is something which is separate from something else.’

“I'm not failing - I'm Learning"
Quellcrist Falconer - Altered Carbon




However, the general intelligence that is unique in humans can be found in the complexity of interactions between humans. Language is but a shadow of that interaction. The essence of it is in the language games we play.

The nature of human learning is equally odd. We learn because we participate. We learn because we are embedded in a sensory-motor loop. We learn because we are engaged and it manifested in the engagement of our attention. Unlike a computer where new skills can be downloaded, humans learn by participatory experience. As Feynman said, what we cannot create we cannot understand. We learn by recreating. We learn by doing.

This is not a bug of general intelligence, rather it is a feature. Skills are only learned when an agent is able to recreate for itself the skills.

AGI and the Empathy Prior





In Physics we seek out symmetries so as to find invariances in nature and ultimately laws of nature. In Biology, these invariances are expressed on the notion of individuality or self. Invariance in biology is not just a consequence of causational invariance as found in Physics. But rather a consequence of intentionality enabled by actions forged by causality. Intentions however are a compositional thing. But they only scale if there is shared intentionality across the individuals of the collective.

Civilizations and societies scale and eventually take over the world as a consequence of consensus mechanisms that coordinate the many individuals in their respective collectives. The same robustness that private property renders in a free economy is represented in the individual subject stance of members of a species. Decision-making is local but there is an emergent behavior of the collective that preserves its identity.

The Fluid Nature of Individuality




The fear of AI alignment focuses on the wrong problem. The real problem is that our society treats people like replaceable parts. Until society treats people like a mother treats their child, we are never going to achieve a society that aligns with humanity.

Medieval Bureaucracies are Paper Clip Maximizers






This is an old (207) but brief article that explores futuristic literature.

The Progressive Apocalypse and Other Futurismic Delights

Science fiction writers aren't the only people in the business of predicting the future. Futurists — consultants, technology columnists, analysts, venture capitalists, and entrepreneurial pitchmen — spill a lot of ink, phosphors, and caffeinated hot air in describing a vision for a future where we'll get more and more of whatever it is they want to sell us or warn us away from. Tomorrow will feature faster, cheaper processors, more Internet users, ubiquitous RFID tags, radically democratic political processes dominated by bloggers, massively multiplayer games whose virtual economies dwarf the physical economy.

There's a lovely neologism to describe these visions: "futurismic." Futurismic media is that which depicts futurism, not the future. It is often self-serving — think of the antigrav Nikes in Back to the Future III — and it generally doesn't hold up well to scrutiny.

The non-futurismic version of NCC-1701 would be the size of a softball (or whatever the minimum size for a warp drive, transporter, and subspace radio would be). It would zip around the galaxy at FTL speeds under remote control. When it reached an interesting planet, it would beam a stored copy of a landing party onto the surface, and when their mission was over, it would beam them back into storage, annihilating their physical selves until they reached the next stopping point. If a member of the landing party were eaten by a green-skinned interspatial hippie or giant toga-wearing galactic tyrant, that member would be recovered from backup by the transporter beam. Hell, the entire landing party could consist of multiple copies of the most effective crew member onboard: no redshirts, just a half-dozen instances of Kirk operating in clonal harmony.


It seems like the graphic novel - or even the short animation may have been a human form of communication even before writing was. 
What’s more, a flickering flame in the cave may have conjured impressions of motion like a strobe light in a dark club. In low light, human vision degrades, and that can lead to the perception of movement even when all is still - The trick may occur at two levels; one when the eye processes a dimly lit scene, and the second when the brain makes sense of that limited, flickering information.

Early Humans Made Animated Art

How Paleolithic artists used fire to set the world’s oldest art in motion.
Artists at Lascaux used fire to see inside caves, but the glow and flicker of flames may also have been integral to the stories the paintings told. “Today, when you light the whole cave, it is very stupid because you kill the staging,” says Jean-Michel Geneste, Lascaux’s curator, the director of France’s National Center of Prehistory, and the head of the archaeological project I worked on that summer. Worse yet, most people only see cave paintings in cropped photographs that are evenly lit with lights that are strong and white. According to Geneste, this removes the images from the context of the story they were meant to tell and makes the colors in the paintings colder, or bluer, than Paleolithic people would have seen them.

Reconstructions of the original grease lamps produce a circle of light about 10 feet in diameter, which is not much larger than many images in the cave. Geneste believes that early artists used this small area of light as a story-telling device. “It is very important: the presence of the darkness, the spot of yellow light, and inside it one, two, three animals, no more,” Geneste says. “That’s a tool in a narrative structure,” he explains. Just as a sentence generally describes a single idea, the light from a grease lamp would illuminate a single part of a story. Whatever tales may have been told inside Lascaux have been lost to history, but it is easy to imagine a person moving their fire-lit lamp along the walls as they unraveled a story step-by-step, using the darkness as a frame for the images inside a small circle of firelight.

Geneste supports his hypothesis by pointing to the various sizes of animals. “If you want to have several animals in a narrative relationship it is necessary to have them small,” he says. “If you want only one animal, you make them big.” If Geneste is right, the paintings I saw in the Hall of Bulls could have been read like a comic strip, as a series of frames: first the bison, then two black horses, more horses, a focus on the bison, and so on down the length of the chamber.


The complexity of the problems life presents may be the portals to progress - and certainly evolution. However - this is a weak signal in relation to malaria.

A malaria vaccine with live parasites shows promise in a small trial

Next steps include figuring out whether the results hold up in larger trials
In a one-two punch, a malaria vaccine in development pairs a shot of the live parasite that causes the disease with a whammy of infection-fighting drugs to immediately quell it.

The candidate is the latest vaccine to show promise against a formidable foe, bolstering hopes that an effective shot might be on the horizon. Malaria, a disease caused by the parasite Plasmodium falciparum, affects more than 200 million people around the world every year. In 2019, an estimated 409,000 people died from the mosquito-borne disease, 67 percent of whom were children younger than 5.

The live parasite vaccine and drug combo showed 87.5 percent efficacy in a small group of healthy adult participants, researchers reported June 30 in Nature. The live parasite shot — which is followed by a dose of one of two anti-malarial drugs to eliminate the infection — not only protected people from the same strain included in the vaccine, but most people could also fend off a different parasite strain that circulates in Brazil.  


Covid has revealed the wonder of mRNA approaches to developing effective vaccines and the promises of other treatments. This is a good signal of ongoing progress.
This increased speed may not be the only benefit; more precisely controlling the nanoparticles' size could make treatments more effective. 
"We believe that this microfluidic technology has the potential to not only play a key role in the formulation of current COVID vaccines," says Mitchell, "but also to potentially address the immense need ahead of us as mRNA technology expands into additional classes of therapeutics."

New microfluidic device delivers mRNA nanoparticles a hundred times faster

The COVID vaccines currently being deployed were developed with unprecedented speed, but the mRNA technology at work in some of them is an equally impressive success story. Because any desired mRNA sequence can be synthesized in massive quantities, one of the biggest hurdles in a variety of mRNA therapies is the ability to package those sequences into the lipid nanoparticles that deliver them into cells.

Now, thanks to manufacturing technology developed by bioengineers and medical researchers at the University of Pennsylvania, a hundred-fold increase in current microfluidic production rates may soon be possible.

The researchers' advance stems from their design of a proof-of-concept microfluidic device containing 128 mixing channels working in parallel. The channels mix a precise amount of lipid and mRNA, essentially crafting individual lipid nanoparticles on a miniaturized assembly line.


The complexity of our biosphere has much to teach us about how new molecules can be found, produced and ultimately manufactured. An amazing part of this signal is that children’s toys have become so sophisticated that afford themselves to be parts in more specialized tools. 
an extract from the leaves disarms even the hyper-virulent MRSA strains capable of causing serious infections in healthy athletes. Experiments also showed the extract did not disturb normal, healthy bacteria on skin cells.
Finally, the researchers demonstrated how the extract works, by inhibiting the ability of MRSA bacteria to communicate with one another, a process known as quorum sensing. MRSA uses this sensing signaling system to make toxins and ramp up its virulence.
"Our homemade piece of equipment really helped accelerate the pace of our discovery," Quave says. "We were able to isolate this molecule and derive pure crystals of it, even though it only makes up a mere .0019 percent of the chestnut leaves."

New molecule found in chestnut leaves disarms dangerous staph bacteria

Scientists have isolated a molecule, extracted from the leaves of the European chestnut tree, with the power to neutralize dangerous, drug-resistant staph bacteria. Frontiers in Pharmacology has published the finding, led by scientists at Emory University.

The researchers dubbed the molecule Castaneroxy A, after the genus of the European chestnut, Castanea. The use of chestnut leaves in traditional folk remedies in rural Italy inspired the research.

"We were able to isolate this molecule, new to science, that occurs only in very tiny quantities in the chestnut leaves," says Cassandra Quave, senior author of the paper and associate professor in Emory's Center for the Study of Human Health and the School of Medicine's Department of Dermatology. "We also showed how it disarms Methicillin-resistant Staphylococcus aureus by knocking out the bacteria's ability to produce toxins."

"We're trying to fill the pipeline for antimicrobial drug discovery with compounds that work differently from traditional antibiotics," Quave says. "We urgently need these new strategies." She notes that antimicrobial infections kill an estimated 700,000 globally each year, and that number is expected to grow exponentially if new methods of treatment are not found.

the researchers wanted to isolate these active ingredients from the plant extract. The process is painstaking when done manually, because plant extracts typically contain hundreds of different chemicals. Each chemical must be separated out and then tested for efficacy. Large scale fraction collectors, coupled to high-performance liquid chromatographic systems, automate this separation process, but they can cost tens of thousands of dollars and did not have all the features the Quave lab needed.

Marco Caputo, a research specialist in the lab, solved the problem. Using a software device from a child's toy, the LEGO MINDSTORMS robot creator, a few LEGO bricks, and some components from a hardware store, Caputo built an automated liquid separator customized to the lab's needs for $500. The lab members dubbed the invention the LEGO MINDSTORMS Fraction Collector. They published instructions for how to build it in a journal so that other researchers can tap the simple, but effective, technology.


Hacking matter is a concept that’s been around for a couple of decades at least. It seems that new signals of the future of matter emerge everyday. Here’s a small signal of new devices, sensors and computational capacity in the next few decades.
"are excited about discovering what can happen in other states we force upon nature and predict that other structures that couple additional degrees of freedom are possible. We hope that miniaturization and flipping through sliding will improve today's electronic devices, and moreover, allow other original ways of controlling information in future devices. In addition to computer devices, we expect that this technology will contribute to detectors, energy storage and conversion, interaction with light, etc. Our challenge, as we see it, is to discover more crystals with new and slippery degrees of freedom."

The world's thinnest technology—only two atoms thick

Researchers from Tel Aviv University have engineered the world's tiniest technology, with a thickness of only two atoms. According to the researchers, the new technology proposes a way for storing electric information in the thinnest unit known to science, in one of the most stable and inert materials in nature. The allowed quantum-mechanical electron tunneling through the atomically thin film may boost the information reading process much beyond current technologies.

"The ability to force a crystalline and electronic arrangement in such a thin system, with unique polarization and inversion properties resulting from the weak Van der Waals forces between the layers, is not limited to the boron and nitrogen crystal," adds Dr. Shalom. "We expect the same behaviors in many layered crystals with the right symmetry properties. The concept of interlayer sliding as an original and efficient way to control advanced electronic devices is very promising, and we have named it Slide-Tronics."


The world is changing everywhere in and in all ways. This is not good news.
The cryosphere holds almost three-quarters of Earth's fresh water, and in some mountainous regions, dwindling glaciers threaten drinking water supplies.

Earth's cryosphere is shrinking by 87,000 square kilometers per year

The global cryosphere—all of the areas with frozen water on Earth—shrank by about 87,000 square kilometers (about 33,000 square miles, an area about the size of Lake Superior) per year on average between 1979 and 2016, as a result of climate change, according to a new study. This research is the first to make a global estimate of the surface area of the Earth covered by sea ice, snow cover and frozen ground.

The extent of land covered by frozen water is just as important as its mass because the bright white surface reflects sunlight so effectively, cooling the planet. Changes in the size or location of ice and snow can alter air temperatures, change the sea level and even affect ocean currents worldwide.

The new study is published in Earth's Future, AGU's journal for interdisciplinary research on the past, present and future of our planet and its inhabitants.


A good signal supporting renewable energy generation for the earth’s colder climates.

Sub-zero water splitting marks a new dawn for solar hydrogen production

Researchers have developed a solar-powered system that splits water at -20°C. The technology could serve as a renewable fuel source in high altitude and polar environments.

Using hydrogen as a fuel source is preferable to fossil fuels as it is renewable and contributes very little, if at all, to the greenhouse effect. In areas where the temperature is regularly below freezing, hydrogen fuel stores easily in tanks, so a method that produces hydrogen locally would go a long way to fulfilling the energy needs of remote populations. A problem with this is that most conventional methods for producing hydrogen do not work well at sub-zero temperatures.

Now, a team of researchers in Germany, led by Matthias May of the University of Ulm, has devised a technology that would allow hydrogen production at low temperatures. The method works by using electrolytes with low freezing points, such as dilute sulfuric acid, to allow the use of water at lower temperatures. This is combined with strict thermal control of the whole device to prevent loss of heat to the environment and to transfer additional heat energy from the solar cell to the electrolyte, resulting in an interior working temperature of around 10°C.


Here is a wonderful 1 hour Youtube from the Long Now Foundation about the Great Mothers of our forests and the plant Internet provided by mycelial networks.

Suzanne Simard | Mother Trees and the Social Forest

Forest Ecologist Suzanne Simard reveals that trees are part of a complex, interdependent circle of life; that forests are social, cooperative creatures connected through underground mycorrhizal networks by which trees communicate their vitality and vulnerabilities, and share and exchange resources and support. 

Simard's extraordinary research and tenacious efforts to raise awareness on the interconnectedness of forest systems, both above and below ground, has revolutionized our understanding of forest ecology. This increasing knowledge is driving a call for more sustainable practices in forestry and land management, ones that develop strategies based on the forest as a whole entity, not on trees as isolated individuals.

Dr. Suzanne Simard is a Professor of Forest Ecology at the University of British Columbia and the author of "Finding the Mother Tree: Discovering the Wisdom of the Forest" (pub. 5/4/21). An active field researcher for decades, her scientific studies and observations built the foundations for our new understanding of the complexity of forest systems. Simard's current collaboration The Mother Tree Project, is investigating forest renewal practices that will protect biodiversity, carbon storage and forest regeneration as the climate changes.


Another good signal of the emerging transformation of global energy politics.

Battery-powered trains could be a climate game changer. Is everyone all aboard?

Colossal freight locomotives are a fixture of the American landscape, but their 4,400-horsepower engines collectively burn 3.5 billion gallons of diesel annually, at a time when railroads and other fossil fuel users face pressure to reduce pollution and greenhouse gas emissions.

With little fanfare, however, the industry has begun operating locomotives that run on stored electrical power, moving toward a future in which toy shops are not the only source of battery trains. American passenger lines could also be transformed by the technology, though California rail officials say it will not work for the state's bullet train.

In a just-completed test, BNSF ran a freight train from Barstow to Stockton with an experimental battery locomotive, coupled with two diesel locomotives, and achieved an 11% reduction in fuel consumption, along with similar reductions in emissions of nitrogen oxides, small particulates and greenhouse gasses. An upgraded future operational version is expected to improve fuel efficiency by 30%.

The test was a "defining moment for freight rail," accelerating the industry to eventual zero-emission locomotives, said Eric Gebhardt, chief technology officer at Wabtec, which developed the system at its research center near Lake Erie in northern Pennsylvania.

Battery- and hydrogen fuel cell-powered trains are among the rail industry's only viable options for reducing greenhouse gasses. Every battery locomotive that replaces a diesel will reduce carbon dioxide emissions by 3,000 tons per year, Wabtec estimates.



#micropoem



mhm - 
difference between -
that moment-in-sight - 
and the after that - 
leveling-up - 
is just that - 
bigger bandwidth - 
but with -
emergents of spectral-turbulences - 


mhm - 
my style is -
what i’m comfortable with - 
my growth - well being is -
becoming comfortable with -
more complexity of choice-afford-dancing - 
more complex - 
dimensional - 
homeostasing - 
a sense of meta-social-selfing -