Thursday, June 11, 2020

Friday Thinking 12 June 2020

Friday Thinking is a humble curation of my foraging in the digital environment. My purpose is to pick interesting pieces, based on my own curiosity (and the curiosity of the many interesting people I follow), about developments in some key domains (work, organization, social-economy, intelligence, domestication of DNA, energy, etc.)  that suggest we are in the midst of a change in the conditions of change - a phase-transition. That tomorrow will be radically unlike yesterday.

Many thanks to those who enjoy this.

In the 21st Century curiosity will SKILL the cat.

Jobs are dying - Work is just beginning.
Work that engages our whole self becomes play that works.

To see red - is to know other colors - without the ground of others - there is no figure - differences that make a defference.

'There are times, when I catch myself believing there is something which is separate from something else.'

“Be careful what you ‘insta-google-tweet-face’”
Woody Harrelson - Triple 9



According to a recent study by Oxfam International, in 2010 the top 388 richest people owned as much wealth as the poorest half of the world’s population– a whopping 3.6 billion people. By 2014, this number was down to 85 people. Oxfam claims that, if this trend continues, by the end of 2016 the top 1% will own more wealth than everyone else in the world combined. At the same time, according to Oxfam, the extremely wealthy are also extremely efficient in dodging taxes, now hiding an estimated $7.6 trillion in offshore tax-havens.


Why should we care about such gross economic inequality?[4] After all, isn’t it natural? The science of flow says: yes, some degree of inequality is natural, but extreme inequality violates two core principles of systemic health: circulation and balance. 

The Science of Flow Says Extreme Inequality Causes Economic Collapse




 Yes, there’s this ancient belief in panpsychism: “Pan” meaning “every,” “psyche” meaning “soul.” There are different versions of it depending on which philosophical or religious tradition you follow, but basically it meant that everything is ensouled. Now, I don’t believe that a stone is ensouled or a planet is ensouled. But if you take a more conceptual approach to consciousness, the evidence suggests there are many more systems that have consciousness—possibly all animals, all unicellular bacteria, and at some level maybe even individual cells that have an autonomous existence. We might be surrounded by consciousness everywhere and find it in places where we don’t expect it because our intuition says we’ll only see it in people and maybe monkeys and also dogs and cats. But we know our intuition is fallible, which is why we need science to tell us what the actual state of the universe is.


It’s terribly elegant in its simplicity. You don’t say consciousness only exists if you have more than 42 neurons or 2 billion neurons or whatever. Instead, the system is conscious if there’s a certain type of complexity. And we live in a universe where certain systems have consciousness. It’s inherent in the design of the universe. Why is that so? I don’t know. Why does the universe follow the laws of quantum mechanics? I don’t know. Can I imagine a universe where the laws of quantum mechanics don’t hold? Yes, but I don’t happen to live in such a universe, so I believe our universe has certain types of complexity and a system that gives rise to consciousness. Suddenly the world is populated by entities that have conscious awareness, and that one simple principle leads to a number of very counterintuitive predictions that can, in principle, be verified.

The Spiritual, Reductionist Consciousness of Christof Koch





It’s only in the final chapter that Boldizzoni finally articulates his own view of what capitalism actually is and offers his account why it has outlasted so many of its critics. Capitalism has three core “building blocks,” he argues: minority control over the means of production, the use of markets to allocate goods and resources, and a “bourgeois culture . . . oriented toward the acquisition of wealth for personal purposes.” In turn, these conditions require a “hierarchical social structure” and an “individualistic orientation”—features more deeply embedded in Western culture than most of capitalism’s critics have recognized, and more crucial to capitalism’s longevity than they have credited. The political, economic, and social structures of society, he argues, “are held together in a coherent way by a powerful glue: this glue is called culture, and its molecules are the meanings that humans associate with their actions, with those of their fellow humans, and with existence in general.”  


A line from Ursula K. LeGuin now circulates widely on the left: “We live in capitalism. Its power seems inescapable. So did the divine right of kings.” To this, Boldizzoni might add: sure, but ending the divine right of kings took a millennium.

When Will Capitalism End?




Consider Heraclitus’ ‘Nature loves to hide’; Blaise Pascal’s ‘The eternal silence of these infinite spaces terrifies me’; or Friedrich Nietzsche’s ‘If a temple is to be erected, a temple must be destroyed.’ Heraclitus comes before and against Plato and Aristotle, Pascal after and against RenĂ© Descartes, Nietzsche after and against Kant and G W F Hegel. Might the history of thought be actually driven by aphorism?


Much of the history of Western philosophy can be narrated as a series of attempts to construct systems. Conversely, much of the history of aphorisms can be narrated as an animadversion, a turning away from such grand systems through the construction of literary fragments. The philosopher creates and critiques continuous lines of argument; the aphorist, on the other hand, composes scattered lines of intuition. One moves in a chain of logic; the other by leaps and bounds.


Good aphorisms demand to be interpreted. And in their interpretation is an invitation for the readers to engage in their own philosophical enterprise – to do philosophy themselves. Aphorisms, then, are at once before, against and after philosophy.

In praise of aphorisms





This is a great signal from a famous science fiction writer familiar with Modern Monetary Theory (please everyone become educated in this - it is the future of our economy)

Never make the mistake of thinking “efficient” is synonymous with “good”

The Climate Case for a Jobs Guarantee

Is there enough work for everyone? Kim Stanley Robinson on the future of planetary employment.

Say it’s the very near future, and you’re a worker put out of work in the declining oil industry. You’re highly educated, and you’ve been well-compensated, but as it becomes clear that burning more oil will wreck Earth and civilization, the stuff you make gets properly priced to reflect that reality, and quickly your industry ceases to exist. Good for the planet, but you’re out of a job! What to do?


You go to the local job center, which tells you the U.S. Department of Energy is sponsoring a public-private company to build direct-air-capture factories. Now instead of pumping a source of carbon dioxide out of the ground, you get to suck CO₂ out of the atmosphere and inject it back underground. You already know how to work with pumps and pipes from your old job, and though CO₂ removal is a new industry, it’s scaling up fast. And you have a real right to work, as stated in the United Nations Universal Declaration of Human Rights—and, ever since passage of the Great Pandemic Recovery Act, as stated in federal law, too. A good job is a good job.


The scenario outlined above is compiled from signs coming from all over, not least of which are the weekly U.S. unemployment numbers that have been reaching seven digits. There’s a major-party presidential candidate out there right now calling for a public jobs corps consisting of 100,000 health workers. And there’s also an economic case for a full-employment vision expressed by modern monetary theory. This economics discipline is usually understood to be a new kind of Keynesianism that might replace austerity policies of the neoliberal era. It advocates creating new money to pay for necessary work and argues that government debt can always be dealt with by later government actions, so creating this new money for good purposes need not be regarded as wrong or dangerous. Some conventional economists have attacked what they see as MMT’s cavalier treatment of money, and critics sometimes call the discipline “magic money tree.” Inflation might result from such money creation—or deflation. Opinions differ, but all agree destabilization would be disastrous.



This is an interesting signal of the social affordances of online tools from Wikipedia to ….. 

“What’s special about a Google Doc versus a newsfeed is its persistence and editability,” says Clay Shirky, the vice provost for educational technology at New York University.

What makes Google Docs especially attractive is that they are at once dynamic and static, he says. They’re editable and can be viewed simultaneously on countless screens, but they are easily shareable via tweet or post

How Google Docs became the social media of the resistance

Facebook and Twitter might have the bells and whistles, but the word processing software's simplicity and accessibility have made it a winning tool.

In the week after George Floyd’s murder, hundreds of thousands of people joined protests across the US and around the globe, demanding education, attention, and justice. But one of the key tools for organizing these protests is a surprising one: it’s not encrypted, doesn’t rely on signing in to a social network, and wasn’t even designed for this purpose. It’s Google Docs.


In just the last week, Google Docs has emerged as a way to share everything from lists of books on racism to templates for letters to family members and representatives to lists of funds and resources that are accepting donations. Shared Google Docs that anyone can view and anyone can edit, anonymously, have become a valuable tool for grassroots organizing during both the coronavirus pandemic and the police brutality protests sweeping the US. It’s not the first time. In fact, activists and campaigners have been using the word processing software for years as a more efficient and accessible protest tool than either Facebook or Twitter.


Google Docs was launched in October 2012. It quickly became popular, not only because Google email accounts were so widespread already, but also because it allows multiple users to collaborate and edit simultaneously. Microsoft Word, the incumbent, finally had a real rival.



This is definitely a good signal of the times and the future. It is a matter of time before such systems influence the nature of all work.

Microsoft 'to replace journalists with robots'

Microsoft is to replace dozens of contract journalists on its MSN website and use automated systems to select news stories, US and UK media report.

The curating of stories from news organisations and selection of headlines and pictures for the MSN site is currently done by journalists.


Artificial intelligence will perform these news production tasks, sources told the Seattle Times.

Microsoft said it was part of an evaluation of its business.


The US tech giant said in a statement: "Like all companies, we evaluate our business on a regular basis. This can result in increased investment in some places and, from time to time, redeployment in others. These decisions are not the result of the current pandemic."



This is a good signal of the ongoing progress toward a full-spectrum capacity for the ‘quantified self’ - and further knowledge of how the brain and body work in real time.

Our group in Nottingham, alongside partners at UCL, are now driving this research forward, not only to develop a new understanding of brain function, but also to commercialize the equipment that we have developed.

Wearable brain scanner technology expanded for whole head imaging

Scientists from the University of Nottingham developed an initial prototype of a new generation of brain scanner in 2018 which is a lightweight device that can be worn on the head like a hat, and can scan the brain even whilst a patient moves. Their latest research has now expanded this to a fully functional 49 channel device that can be used to scan the whole brain and track electrophysiological processes that are implicated in a number of mental health problems. Their findings have been published in Neuroimage.


Professor Matt Brookes from the University of Nottingham has led the development of this wearable scanner, he said: "Understanding mental illness remains one of the greatest challenges facing 21st century science. From childhood illnesses such as Autism, to neurodegenerative diseases such as Alzheimer's, human brain health affects millions of people throughout the lifespan. In many cases, even highly detailed brain images showing what the brain looks like fail to tell us about underlying pathology, and consequently there is an urgent need for new technologies to measure what the brain actually does in health and disease."


Brain cells operate and communicate by producing electrical currents. These currents generate tiny magnetic fields that can be detected outside the head. Researchers use MEG to map brain function by measuring these magnetic fields. This allows for a millisecond-by-millisecond picture of which parts of the brain are engaged when we undertake different tasks, such as speaking or moving.



This is a great signal of the progress (slow as it might seem) of using the memristor in our computational paradigms.

Memristors, or memory transistors, are an essential element in neuromorphic computing. In a neuromorphic device, a memristor would serve as the transistor in a circuit, though its workings would more closely resemble a brain synapse—the junction between two neurons. The synapse receives signals from one neuron, in the form of ions, and sends a corresponding signal to the next neuron.


A transistor in a conventional circuit transmits information by switching between one of only two values, 0 and 1, and doing so only when the signal it receives, in the form of an electric current, is of a particular strength. In contrast, a memristor would work along a gradient, much like a synapse in the brain. The signal it produces would vary depending on the strength of the signal that it receives. This would enable a single memristor to have many values, and therefore carry out a far wider range of operations than binary transistors.

Engineers put tens of thousands of artificial brain synapses on a single chip

MIT engineers have designed a "brain-on-a-chip," smaller than a piece of confetti, that is made from tens of thousands of artificial brain synapses known as memristors—silicon-based components that mimic the information-transmitting synapses in the human brain.


The researchers borrowed from principles of metallurgy to fabricate each memristor from alloys of silver and copper, along with silicon. When they ran the chip through several visual tasks, the chip was able to "remember" stored images and reproduce them many times over, in versions that were crisper and cleaner compared with existing memristor designs made with unalloyed elements.


Their results, published today in the journal Nature Nanotechnology, demonstrate a promising new memristor design for neuromorphic devices—electronics that are based on a new type of circuit that processes information in a way that mimics the brain's neural architecture. Such brain-inspired circuits could be built into small, portable devices, and would carry out complex computational tasks that only today's supercomputers can handle.



Another signal about the vital role of our microbiome and the role that sleep plays in maintaining wellness.

Animals completely deprived of sleep die. Yet scientists have found it oddly hard to say exactly why sleep loss is lethal.

Why Sleep Deprivation Kills

Publishing today in the journal Cell, she and her colleagues offer evidence that when flies die of sleeplessness, lethal changes occur not in the brain but in the gut. The indigo labyrinths of the flies’ small intestines light up with fiery fuchsia in micrographs, betraying an ominous buildup of molecules that destroy DNA and cause cellular damage. The molecules appear soon after sleep deprivation starts, before any other warning signs; if the flies are allowed to sleep again, the rosy bloom fades away. Strikingly, if the flies are fed antioxidants that neutralize these molecules, it does not matter if they never sleep again. They live as long as their rested brethren.


The results suggest that one very fundamental job of sleep — perhaps underlying a network of other effects — is to regulate the ancient biochemical process of oxidation, by which individual electrons are snapped on and off molecules in service to everything from respiration to metabolism. Sleep, the researchers imply, is not solely the province of neuroscience, but something more deeply threaded into the biochemistry that knits together the animal kingdom.



What do we know of consciousness? Not much - this is an important signal of efforts to explore the mind with both new technology and ancient plant medicines

Psychedelic drug psilocybin tamps down brain's ego center

Perhaps no region of the brain is more fittingly named than the claustrum, taken from the Latin word for "hidden or shut away." The claustrum is an extremely thin sheet of neurons deep within the cortex, yet it reaches out to every other region of the brain. Its true purpose remains "hidden away" as well, with researchers speculating about many functions. For example, Francis Crick of DNA-discovery fame believed that the claustrum is the seat of consciousness, responsible for awareness and sense of self.


What is known is that this region contains a large number of receptors targeted by psychedelic drugs such as LSD or psilocybin ¾ the hallucinogenic chemical found in certain mushrooms. To see what happens in the claustrum when people are on psychedelics, Johns Hopkins Medicine researchers compared the brain scans of people after they took psilocybin with their scans after taking a placebo.


Their findings were published online on May 23, 2020, in the journal NeuroImage.

For this new study, the researchers used fMRI with 15 people and observed the claustrum brain region after the participants took either psilocybin or a placebo. They found that psilocybin reduced neural activity in the claustrum by 15% to 30%. This lowered activity also appeared to be associated with stronger subjective effects of the drug, such as emotional and mystical experiences. The researchers also found that psilocybin changed the way that the claustrum communicated with brain regions involved in hearing, attention, decision-making and remembering.



This is a great signal of the post-human human - as a biosynthetic ecology.

Synthetic red blood cells mimic natural ones, and have new abilities

Scientists have tried to develop synthetic red blood cells that mimic the favorable properties of natural ones, such as flexibility, oxygen transport and long circulation times. But so far, most artificial red blood cells have had one or a few, but not all, key features of the natural versions. Now, researchers reporting in ACS Nano have made synthetic red blood cells that have all of the cells' natural abilities, plus a few new ones.


The artificial cells were similar in size, shape, charge and surface proteins to natural cells, and they could squeeze through model capillaries without losing their shape. In mice, the synthetic RBCs lasted for more than 48 hours, with no observable toxicity. The researchers loaded the artificial cells with either hemoglobin, an anticancer drug, a toxin sensor or magnetic nanoparticles to demonstrate that they could carry cargoes. The team also showed that the new RBCs could act as decoys for a bacterial toxin. Future studies will explore the potential of the artificial cells in medical applications, such as cancer therapy and toxin biosensing, the researchers say.



This is a great signal of biotechnology and 3D printing - and the advent of a post-human capability for healing and development. The 1 min video is very clear.

 the new ear began to take shape within seconds as they applied the near-infrared light beam. The final ear shape developed over the course of a month as cartilage cells grew on the structure they had printed—the researchers described it as looking almost exactly like a natural ear. 

Using near-infrared light to 3-D print an ear inside the body

A team of researchers with members from several institutions in China, one in the U.S. and one in Belgium, has developed a method for 3-D printing an ear inside of the body. In their paper published in the journal Science Advances, the group describes their method and how well it worked on test mice.


Three-dimensional printing has evolved over the last several years to include the use of a wide variety of materials to create products. In recent years, it has come to be used in medical applications to repair defective tissue. In such applications, ultraviolet light is used to 3-D print tissue-like material through polymerization, in which materials become denser and stick together when exposed to the light. In such efforts, surgery is required to expose the tissue that needs to be repaired. In this new effort, the researchers used near-infrared light to accomplish much the same thing, but in a way that does not require surgery.


The technique involves first injecting a bioink (made of hydrogel particles and cartilage cells) into the patient. Next, a near-infrared light beam is directed at a digital micromirror device chip, which organizes the beam of light into a desired shape—the reorganized beam is then reflected down onto the patient where it penetrates the skin and collides with the bionk inside of the body. The light beam forces the bioink to form into a desired shape and to harden—the finished product resembles the cartilage that normally forms the shape of an ear. In their testing, the team used test mice with one deformed ear—the new ear was programmed using a mirror-image of the ear that was not deformed.



This is an amazing signal of the future of post pandemic fashions.

Shocker! Japan firms' electrifying fabric zaps bacteria

It's a shocking idea: a fabric that can produce small amounts of electricity powered by movement, allowing your clothing to zap microbes and bacteria as you go about your day.

A pair of Japanese firms say that's exactly what their new product can do, and are touting it for everything from curbing body odour to offering the ideal material for protective gear like face masks.


The fabric jointly developed by electronics company Murata Manufacturing and Teijin Frontier, dubbed PIECLEX, generates power from the expansion and contraction of the material itself, including when worn by someone moving around.


The low voltages aren't strong enough to be felt by the wearer, but they effectively stop bacteria and viruses from multiplying inside the fabric, the companies said.


Thursday, June 4, 2020

Friday Thinking 5 June 2020

Friday Thinking is a humble curation of my foraging in the digital environment. My purpose is to pick interesting pieces, based on my own curiosity (and the curiosity of the many interesting people I follow), about developments in some key domains (work, organization, social-economy, intelligence, domestication of DNA, energy, etc.)  that suggest we are in the midst of a change in the conditions of change - a phase-transition. That tomorrow will be radically unlike yesterday.

Many thanks to those who enjoy this.

In the 21st Century curiosity will SKILL the cat.

Jobs are dying - Work is just beginning.
Work that engages our whole self becomes play that works.

To see red - is to know other colors - without the ground of others - there is no figure - differences that make a defference.

'There are times, when I catch myself believing there is something which is separate from something else.'

“Be careful what you ‘insta-google-tweet-face’”
Woody Harrelson - Triple 9

Content

Quotes:

A touch of absurdity can help to wrap your mind around reality

Review of Stuart Kauffman’s A World Beyond Physics and Its Parallel with McLuhan’s Reversal of Cause and Effect

Are there laws of history?

The power thinker


Articles:

How a Canadian Newsroom Launched a Co-Op to Save Itself from Bankruptcy

African scientists leverage open hardware

Teens on TikTok are exposing a generational rift between parents and kids over how they treat Black Lives Matter protests

Society Is Becoming Germaphobic. Let’s Not Stay That Way.

The information theory of individuality

The Genome Aggregation Database (gnomAD)

Humans and Neanderthals: Less different than polar and brown bears

City foxes are becoming more similar to domesticated dogs as they adapt to their environment

New molecule stops drug cravings in mice, with fewer side effects

New technology enables fast protein synthesis

Researchers develop 'poisoned arrow' to defeat antibiotic-resistant bacteria

Spreading the Word on a Possible Alzheimer’s Treatment

What happens when we experience the ‘Ground’ as the ‘Figure’?





According to research on the ‘meaning maintenance model’ of human reasoning, surreal and absurd art can be so unsettling that the brain reacts as if it is feeling physical pain, yet it ultimately leads us to reaffirm who we are, and sharpens the mind as we look for new ways to make sense of the world. The findings also suggest new ways to improve education, and even help to explain our responses to some of the more absurd political events of recent years.


The meaning maintenance model was first proposed by three psychologists – Steven Heine, Travis Proulx and Kathleen Vohs – in 2006. They were inspired by the French-Algerian philosopher Albert Camus, who argued that the human mind continuously attempts to construct a view of reality as a single, coherent whole – an urge he described in The Myth of Sisyphus (1942) as ‘nostalgia for unity’.


Heine and his team proposed that our mental representation of the world is like a delicate web of interconnected beliefs, documenting the relations between ourselves and the people, places and objects around us. When we are confronted with an apparently inexplicable event that appears to break that framework, we feel profound uncertainty – the ‘feeling of the absurd’.

A touch of absurdity can help to wrap your mind around reality

https://psyche.co/ideas/a-touch-of-absurdity-can-help-to-wrap-your-mind-around-reality?utm_source=Psyche+Magazine&utm_campaign=9fe151e629-EMAIL_CAMPAIGN_2020_05_25_07_27&utm_medium=email&utm_term=0_76a303a90a-9fe151e629-71392152 




Kauffman (2019, 12 - 13) states that Weinberg is categorically wrong and points out, “One thing missing in the world according to physics is the crucial idea of agency… Given agency, meaning exists in the universe.” He then asks "How did the universe get from matter to mattering? In the meaningless, numb universe of Weinberg, where does mattering come from?” Mattering, in Kauffman’s play on words, is simply meaning or information and information is about the informing of a living agent that is able to

propagate its organization. Physics has no explanation of agency or an agent capable of propagating its organization.


A living agent to create and propagate its organization must be able to take energy from its environment and convert it into work which requires constraints. The constraint of the cylinder in an automobile engine that directs the energy of the gasoline air mixture explosion to push against the piston and hence do work is an example of the necessity of constraints to do work. In a paper entitled Propagating Organization: An Enquiry (Kauffman, Logan, et al. 2007) we argued that the constraints are information and hence possess meaning or meaningfulness. According to Kauffman, this ability for a system to self-organize in such a way as to propagate its organization is the extra ingredient that cannot be explained by physics.

Review of Stuart Kauffman’s A World Beyond Physics and Its Parallel with McLuhan’s Reversal of Cause and Effect

https://jps.library.utoronto.ca/index.php/nexj/article/view/34237/26220




When datasets are created and archives accessed digitally, users aren’t viewing a simple facsimile of the original materials. They are looking at computer files that will have undergone a series of transformations that mask the assumptions built into the digital architecture, as well as the conditions under which the data was produced. Besides, for the majority of historians, ‘historical facts’ are not discrete items that exist independently, awaiting scholars who will hunt them down, gather them up and catalogue them safely. They need to be created and interpreted. Textual archives might seem relatively easy to reproduce, for example, but, just as with archaeological digs, the physical context in which documents are found is essential to their interpretation: what groups, or items, or experiences did past generations value and record, and which of these must be salvaged from the margins of the archives? What do the marginalia tell us about how the meanings of words have changed?


Mathematical, data-driven, quantitative models of human experience that aim at detachment, objectivity and the capacity to develop and test hypotheses need to be balanced by explicitly fictional, qualitative and imaginary efforts to create and project a lived future that enable their audiences to empathically ground themselves in the hopes and fears of what might be to come. Both, after all, are unequivocally doing the same thing: using history and historical experience to anticipate the global future so that we might – should we so wish – avoid civilisation’s collapse. That said, the question of who ‘we’ are does, always, remain open.

Are there laws of history?

https://aeon.co/essays/if-history-was-more-like-science-would-it-predict-the-future?utm_source=Aeon+Newsletter&utm_medium=email&utm_campaign=PRELAUNCH_PSYCHE_WEEKLY&utm_source=Aeon+Newsletter&utm_campaign=022dd70458-EMAIL_CAMPAIGN_2020_05_14_02_01&utm_medium=email&utm_term=0_411a82e59d-022dd70458-69459217 




Foucault argued that if you look at the way in which prisons operate, that is, at their mechanics, it becomes evident that they are designed not so much to lock away criminals as to submit them to training rendering them docile. Prisons are first and foremost not houses of confinement but departments of correction. The crucial part of this institution is not the cage of the prison cell, but the routine of the timetables that govern the daily lives of prisoners. What disciplines prisoners is the supervised morning inspections, the monitored mealtimes, the work shifts, even the ‘free time’ overseen by a panoply of attendants including armed guards and clipboard-wielding psychologists.


Importantly, all of the elements of prison surveillance are continuously made visible. That is why his book’s French title Surveiller et punir, more literally ‘Surveil and Punish’, is important. Prisoners must be made to know that they are subject to continual oversight. The purpose of constant surveillance is not to scare prisoners who are thinking of escaping, but rather to compel them to regard themselves as subject to correction. From the moment of morning rise to night’s lights out, the prisoners are subject to ceaseless behavioural inspection.


The crucial move of imprisonment is that of coaxing prisoners to learn how to inspect, manage and correct themselves. If effectively designed, supervision renders prisoners no longer in need of their supervisors. For they will have become their own attendant. This is docility.

The power thinker

https://aeon.co/essays/why-foucaults-work-on-power-is-more-important-than-ever?utm_source=Aeon+Newsletter&utm_medium=email&utm_campaign=PRELAUNCH_PSYCHE_WEEKLY&utm_source=Aeon+Newsletter&utm_campaign=022dd70458-EMAIL_CAMPAIGN_2020_05_14_02_01&utm_medium=email&utm_term=0_411a82e59d-022dd70458-69459217 





This is a good even if weak signal of a possible future trajectory for news media enterprises.

“If last fall we didn’t feel the community was ready to donate, contribute and participate, we probably would have had to stop everything,” said Gilles Carignan, Le Soleil’s director general. “Now, the focus on the community is clearer than ever.”

Readers’ eagerness to support the newsroom financially provided an unexpected jolt. “The biggest surprise for us at the time was a lot of readers wrote to us to say they wanted to help, saying, ‘Hey, I want to maintain local information in Quebec. But I don’t want paper, and you give everything free on the web,’” recalled Carignan.

How a Canadian Newsroom Launched a Co-Op to Save Itself from Bankruptcy

https://gijn.org/2020/05/29/how-a-canadian-newsroom-launched-a-co-op-to-save-itself-from-bankruptcy/ 

As COVID-19 has brought newsrooms worldwide to their knees, one French Canadian outlet is flourishing — less than a year after going bankrupt.


Quebec City’s Le Soleil doubled its number of readers this spring as the pandemic swept the globe. The French-language daily newspaper converted this into 3,500 new subscribers by the end of April, including 1,000 over a single 10-day period, according to Simon Audet, Le Soleil’s head of digital development.


Driving this success is a revamped, reader-first editorial strategy. But first, Le Soleil had to stave off bankruptcy. They did so by forming Canada’s largest newsroom cooperative. Along the way, they found their readers were eager to help save their local news source.


The co-op business model was just a first step. Any sustainable path forward for Le Soleil required an overhauled editorial approach, too, explained Carignan.


As Le Soleil restructured last fall, newsroom staff reached out to readers. They invested in conversations with them, and welcomed feedback. Readers wanted more than just surface-level reporting, Le Soleil found. “[Our readers] gave us all the answers we needed to adjust our content,” said Carignan. “People want content. They will be ready to invest in us, to subscribe if we give them local news but with substance.”



Another important signal of the future of citizen and open-source science and more.

“Open-science hardware is not only important in Africa but all over the world,” Chagas says. “If you have the blueprint for a piece of equipment, you can understand how it works. You can repair your equipment if it breaks down, and, even more importantly, adapt it to your local needs.”

African scientists leverage open hardware

https://www.nature.com/articles/d41586-020-01606-z?utm_source=Nature+Briefing&utm_campaign=ca5b00045f-briefing-dy-20200602&utm_medium=email&utm_term=0_c9dfd39373-ca5b00045f-43585533 

A growing emphasis on do-it-yourself science is helping researchers to equip labs in resource-limited areas.

Founded in 2011 by Lucia Prieto-Godino, now at the Francis Crick Institute in London, Sadiq Yusuf at the Uganda Technology and Management University in Kampala and Tom Baden at the University of Sussex in Brighton, UK, TReND in Africa encourages do-it-yourself research with a focus on low-cost, open-source science. Courses cover such topics as fly genetics, neuroscience and hardware development.


In one example, TReND in Africa instructor and University of Sussex bioengineer AndrĂ© Maia Chagas joined a team including Prieto-Godino and Baden in 2017 to design a microscope. It was built using off-the-shelf and 3D-printed components, and dubbed the €100 lab.


At US$122.91, the device is a fraction of the cost of commercial systems, which can amount to $6,000 or more. The resulting paper in HardwareX helped Kumbol to secure funding from the Mozilla Foundation to organize a follow-up workshop last July at the University of Health and Allied Sciences in Ho, Ghana. He has demonstrated Actifield at the Kwame Nkrumah University of Science and Technology, and has built actimeters for the science department there.



What a fascinating signal that sort of blows up the notion of people on social media being in a bubble or echo-chamber. It also signals the challenge of educating and socializing the digital natives that are coming of age now and will come of age in the future.

Teens on TikTok are exposing a generational rift between parents and kids over how they treat Black Lives Matter protests

https://theintercept.com/2020/03/31/zoom-meeting-encryption/ 

TikTok has been flooded with #blacklivesmatter content following the killing of George Floyd in police custody, and the subsequent protests that have rippled across the globe. 

Many Gen Z kids have found themselves clashing with parents over racial justice issues.


Now, some are taking to TikTok to express their frustration over the difficult conversations they're having with the parents and relatives to bring them up to speed on the Black Lives Matter movement.


Social media is awash with earnest shows of support for the Black Lives Matter movement. The best of these posts have been materially useful to the cause. Others, less so. But on TikTok, Gen Z is modeling the most important tenet of allyship: taking it upon yourself to research, point out, and confront racism, especially when it feels risky or uncomfortable to do so.  



This is an important signal for the future of our health.

Society Is Becoming Germaphobic. Let’s Not Stay That Way.

https://undark.org/2020/05/28/dont-stay-germaphobic/?ref=briefingday.com&curator=briefingday.com&utm_source=briefingday.com&utm_medium=email 

LET’S FACE IT. We’re all germaphobes now.

what if this anxiety crystallizes into a long-term, habitual fear of germs? I believe that such a cultural shift wouldn’t just be unhelpful, it would potentially be a danger to public health — and to the broader social sphere.


To understand why, it’s helpful to remind ourselves that viruses can have beneficial effects. Some viruses, including many bacteriophages, possess life-saving medical powers. Others, including herpesviruses, can lead to serious infections, but in their dormant state may also train the human immune system to fight Listeria food poisoning and bubonic plague. And studies have shown that moderate levels of exposure to pathogenic viruses during early childhood can offer a protective effect later on in life. A study published in the journal Pediatrics in 2016, for instance, found that children who attended daycare before their first birthday experienced fewer bouts of stomach flu later in childhood than peers who didn’t attend daycare. (That study tracked participants only up to age six, though the authors suggest that the protective effect may extend much longer.) In an attempt to completely rid our lives of viruses, we could rob ourselves of some of the protections they afford.


Moreover, the sanitizers and soaps we’re using to immobilize the new coronavirus can also wipe out bacteria that are essential to human health. The human microbiome, the diverse collection of microbes living in and on the human body, has now been established as hugely important to digestive health, metabolic function, and immune responses. Jonathan Eisen, a microbiologist at the University of California, Davis, noted in an interview with Popular Science that hand sanitizer can disturb the microbiome of our skin. (This may allow more dangerous pathogens to take root.) Used excessively, Eisen added, hand sanitizers might also promote antibiotic resistance, another public health threat.



This is a very interesting signal of the future of our understanding of identity and the individual.

From the perspective of physics and chemistry, biological life is surprising. There is no physical or chemical theory from which we can predict biology, and yet if we break down any biological system into its elementary constituents, there is no chemistry or physics remaining unaccounted for

 recent work suggests that viruses like microbes form collective units that facilitate infection .... These observations suggest that viruses in aggregate are individuals but not in the conventional sense. Rather they are what Krakauer …  has called “chimerical individuals.” 

without a rigorous definition of both the environment and the agent it is difficult to speak consistently of individuals. This is analogous to figure-ground separation in gestalt psychology or computer vision. The background of an image carries as much if not more information than the object, and the challenge is to separate the two rather than assume that they are already distinct and independent.

The information theory of individuality

https://link.springer.com/content/pdf/10.1007/s12064-020-00313-7.pdf 

Abstract 

Despite the near universal assumption of individuality in biology, there is little agreement about what individuals are and few rigorous quantitative methods for their identification. Here, we propose that individuals are aggregates that preserve a measure of temporal integrity, i.e., “propagate” information from their past into their futures. We formalize this idea using information theory and graphical models. This mathematical formulation yields three principled and distinct forms of individuality—an organismal, a colonial, and a driven form—each of which varies in the degree of environmental dependence and inherited information. This approach can be thought of as a Gestalt approach to evolution where selection makes figure-ground (agent–environment) distinctions using suitable information-theoretic lenses. A benefit of the approach is that it expands the scope of allowable individuals to include adaptive aggregations in systems that are multi-scale, highly distributed, and do not necessarily have physical boundaries such as cell walls or clonal somatic tissue. Such individuals might be visible to selection but hard to detect by observers without suitable measurement principles. The information theory of individuality allows for the identification of individuals at all levels of organization from molecular to cultural and provides a basis for testing assumptions about the natural scales of a system and argues for the importance of uncertainty reduction through coarse-graining in adaptive systems. 


The question we seek to address is more limited. How do we identify individuals without relying on features like cell membranes that may be solutions to challenges faced by particular systems for maintaining integrity rather than foundational properties? We want to allow for the possibility that microbes and loosely bound ecological assemblages such as microbial mats and cultural and technological systems, when viewed with a mathematical lens, qualify as individuals even though their boundaries are more fluid than the organisms we typically allow. It may also be the case that entities currently considered individuals are indeed individuals but not in the way we think—organisms are more complicated than typical individuality definitions acknowledge.


Individuality can be nested. Given that life is hierarchically organized into trophic and functional levels, we allow the possibility of multiple, parallel levels of individuality. We take this position to be related to the recent suggestion of (Rieppel 2013) where he argues for individuals based on hierarchical complexes of homeostatic properties and (Flack 2017a) who has proposed biological systems are information hierarchies resulting from the collective effects of components estimating, in evolutionary or ecological time, regularities in their environments by coarse-graining or compressing time series data and using these perceived regularities to tune strategies. As coarse-grained (slow) variables become for components better predictors than microscopic behavior (which fluctuates), and component estimates of these variables converge, new levels of organization consolidate.



It may seem like a much longer time since the first full human genome was sequenced - but it is still very early days as not just the genome but proteonic and other molecules are being increasingly understood.

The Genome Aggregation Database (gnomAD)

https://www.nature.com/immersive/d42859-020-00002-x/index.html?utm_source=Nature+Briefing&utm_campaign=d5ab42c08c-briefing-dy-20200528&utm_medium=email&utm_term=0_c9dfd39373-d5ab42c08c-43585533 

A collection of research articles and related content from the gnomAD Consortium that describe and analyse human genetic variation.

The human genome comprises both our protein-coding genes and the regulatory information that controls when, and to what extent, those genes are expressed. While humans mostly share the same repertoire of genes and regulatory elements, the underlying sequences are as diverse as the people on Earth; each individual’s genome is unique. To reflect this diversity and to capture the extent of variation among a large group of individuals on an unprecedented scale, the Genome Aggregation Database (gnomAD) has aggregated 15,708 whole genomes and 125,748 exomes (the protein-coding part of the genome). Analyses of this rich resource have created a catalogue of the different types of variation present, and revealed their potential functional impact and how this information could help to identify disease-causing mutations and to prioritize potential drug targets.



This is a good signal that despite apparent diversity - there is more in common with all humans.

"Our desire to categorize the world into discrete boxes has led us to think of species as completely separate units. Biology does not care about these rigid definitions, and lots of species, even those that are far apart evolutionarily, swap genes all the time. Our predictive metric allows for a quick and easy determination of how likely it is for any two species to produce fertile hybrid offspring. This comparative measure suggests that humans and Neanderthals and Denisovans were able to produce live fertile young with ease."

Humans and Neanderthals: Less different than polar and brown bears

https://phys.org/news/2020-06-humans-neanderthals-polar-brown.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter 

Ancient humans, Neanderthals and Denisovans were genetically closer than polar bears and brown bears, and so, like the bears, were able to easily produce healthy, fertile hybrids according to a study, led by the University of Oxford's School of Archaeology.

The study, published 3 June in the journal Proceedings of the Royal Society B, shows that the genetic distance values between humans and our ancient relatives were smaller than the distance between pairs of species which are known to easily hybridize and have fertile young.


When the distance values between humans, Neanderthals and Denisovans were calculated, they were even smaller than the values between several pairs of species which are known readily and easily to hybridize—including polar bears and brown bears, and coyotes and wolves. This suggests we could have predicted the existence of Neanderthals and Denisovans in our genomes as soon as the first genetic sequences were generated.



An interesting signal of the evolution of evolution even in built environments.

while urban foxes are certainly not domesticated, they are changing in ways that move them closer to what is seen in many domesticated animals.

City foxes are becoming more similar to domesticated dogs as they adapt to their environment

https://phys.org/news/2020-06-city-foxes-similar-domesticated-dogs.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter 

Urban red foxes are becoming more similar to domesticated dogs as they adapt to their city environment, according to a new analysis.

A team led by Dr. Kevin Parsons, of the University of Glasgow's Institute of Biodiversity, Animal Health and Comparative Medicine, has carried out an analysis into the differences between urban and rural red foxes in the UK.


Their findings go some way to explaining how dogs could have evolved into our current pets.


With our current lockdown measures due to the COVID-19 pandemic we are seeing a number of animals more frequently in our cities. It has been known for some time that cities create new habitats for wild populations. While many can't cope, it is recognized that some types of animals are especially good at living within cities. Red foxes are prevalent within several cities within the UK and elsewhere where they have become well-established.



This is an interesting signal for the future of some forms of drug addiction.

New molecule stops drug cravings in mice, with fewer side effects

https://medicalxpress.com/news/2020-05-molecule-drug-cravings-mice-side.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter 

Duke University researchers have developed a synthetic molecule that selectively dampen the physiological rewards of cocaine in mice. It also may represent a new class of drugs that could be more specific with fewer side effects than current medications.


In mice that were treated with the stimulant cocaine or methamphetamine, the new molecule was found to calm their drug-induced hyperactivity and interfere with the dopamine system's ability to change metabolism in the brain's rewards center.


In mice that were allowed to self-administer cocaine, the treatment slowed down their drug use in 20 minutes to an hour, and reduced the amount of drug they used by more than 80 percent, compared to a control group of mice.



This is a signal of the emerging progress in developing more types of proteins to explore their efficacy for various purposes.

"You could design new variants that have superior biological function, enabled by using non-natural amino acids or specialized modifications that aren't possible when you use nature's apparatus to make proteins," says Brad Pentelute, an associate professor of chemistry at MIT and the senior author of the study.

New technology enables fast protein synthesis

https://phys.org/news/2020-05-technology-enables-fast-protein-synthesis.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter 

Many proteins are useful as drugs for disorders such as diabetes, cancer, and arthritis. Synthesizing artificial versions of these proteins is a time-consuming process that requires genetically engineering microbes or other cells to produce the desired protein.


MIT chemists have devised a protocol to dramatically reduce the amount of time required to generate synthetic proteins. Their tabletop automated flow synthesis machine can string together hundreds of amino acids, the building blocks of proteins, within hours. The researchers believe their new technology could speed up the manufacturing of on-demand therapies and the development of new drugs, and allow scientists to design artificial proteins by incorporating amino acids that don't exist in cells.


In a paper appearing today in Science, the researchers showed that they could chemically produce several protein chains up to 164 amino acids in length, including enzymes and growth factors. For a handful of these synthetic proteins, they performed a detailed analysis showing their function is comparable to that of their naturally occurring counterparts.



A signal of important ongoing work that promises very good news about antibiotic resistance.

"This is the first antibiotic that can target Gram-positives and Gram-negatives without resistance," said Zemer Gitai, Princeton's Edwin Grant Conklin Professor of Biology and the senior author on the paper. "From a 'Why it's useful' perspective, that's the crux. But what we're most excited about as scientists is something we've discovered about how this antibiotic works—attacking via two different mechanisms within one molecule—that we are hoping is generalizable, leading to better antibiotics—and new types of antibiotics—in the future."

Researchers develop 'poisoned arrow' to defeat antibiotic-resistant bacteria

https://phys.org/news/2020-06-poisoned-arrow-defeat-antibiotic-resistant-bacteria.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter 

Poison is lethal all on its own—as are arrows—but their combination is greater than the sum of their parts. A weapon that simultaneously attacks from within and without can take down even the strongest opponents, from E. coli to MRSA (methicillin resistant Staphylococcus aureus).


A team of Princeton researchers reported today in the journal Cell that they have found a compound, SCH-79797, that can simultaneously puncture bacterial walls and destroy folate within their cells—while being immune to antibiotic resistance.


Bacterial infections come in two flavors—Gram-positive and Gram-negative—named for the scientist who discovered how to distinguish them. The key difference is that Gram-negative bacteria are armored with an outer layer that shrugs off most antibiotics. In fact, no new classes of Gram-negative-killing drugs have come to market in nearly 30 years.



This is an interesting weak signal of the potential of new forms of treatment modalities - as we learn more about how entangled we are with all manner of phenomena.

“We had noticed in our own data, and in that of other groups, that 40-hertz rhythm power and synchrony are reduced in mouse models of Alzheimer’s disease,” she said, as well as in patients with the disease. Apparently, if you have Alzheimer’s, your brain doesn’t produce strong brain waves in that particular frequency. In 2016, her graduate student Hannah Iaccarino reasoned that perhaps boosting the power of these weakened gamma waves would be helpful in treating this severe and irreversible dementia.

…. the strobe lights had an additional effect on mice: They also cleared out amyloid plaques. But it wasn’t clear exactly how the optogenetic stimulation or the flashing-light therapy could do that.

Spreading the Word on a Possible Alzheimer’s Treatment

https://www.quantamagazine.org/stimulated-brain-waves-offer-a-possible-treatment-for-alzheimers-20200527/?mc_cid=2230c4f095&mc_eid=af018688b8 

Discoveries that transcend boundaries are among the greatest delights of scientific research, but such leaps are often overlooked because they outstrip conventional thinking. Take, for example, a new discovery for treating dementia that defies received wisdom by combining two formerly unrelated areas of research: brain waves and the brain’s immune cells, called microglia. It’s an important finding, but it still requires the buy-in and understanding of researchers to achieve its true potential. The history of brain waves shows why.


Scientists must specialize to succeed. Biologists studying microglia don’t tend to read papers about brain waves, and brain wave researchers are generally unaware of glial research. A study that bridges these two traditionally separate disciplines may fail to gain traction. But this study needed attention: Incredible as it may sound, the researchers improved the brains of animals with Alzheimer’s simply by using LED lights that flashed 40 times a second. Even sound played at this charmed frequency, 40 hertz, had a similar effect.


In an expanded study in Cell, they reported that just as seeing flashes at 40 hertz resulted in fewer plaques in the visual cortex, sound stimulation at 40 hertz reduced amyloid protein in the auditory cortex. Other regions were similarly affected, including the hippocampus — crucial for learning and memory — and the treated mice performed better on memory tests. Exposing the mice to both stimuli, a light show synchronized with pulsating sound, had an even more powerful effect, reducing amyloid plaques in regions throughout the cerebral cortex, including the prefrontal region, which carries out higher-level executive functions that are impaired in Alzheimer’s.



One signal exploring the possible evolution of a social self.

What happens when we experience the ‘Ground’ as the ‘Figure’?

http://www.johnverdon.com/2020/05/what-happens-when-we-experience-ground.html 

Human experience emerges through its entanglements with environments. Entanglements become evident in their own mutual-enactments. To exist is to simultaneously act – in-act/enact. To act is to make a change. A Change is a difference-that-makes-a-difference – which is simultaneously ‘taking a measure’ of a (or the) situation. Taking a measure of the situation – simultaneously enacts accounting -taking account-of the situation.


The question is which differences are ones that make a difference – because to make a difference-that-makes-a-difference – is an accounting of something of ‘value’ – of something worthy of ‘standing out’ – a way of valuing values.