Thursday, February 23, 2017

Friday Thinking 24 Feb. 2017

Hello all – Friday Thinking is a humble curation of my foraging in the digital environment. My purpose is to pick interesting pieces, based on my own curiosity (and the curiosity of the many interesting people I follow), about developments in some key domains (work, organization, social-economy, intelligence, domestication of DNA, energy, etc.)  that suggest we are in the midst of a change in the conditions of change - a phase-transition. That tomorrow will be radically unlike yesterday.

Many thanks to those who enjoy this.
In the 21st Century curiosity will SKILL the cat.
Jobs are dying - work is just beginning.

“Be careful what you ‘insta-google-tweet-face’”
Woody Harrelson - Triple 9

Content
Quotes:

Articles:
Astonishing geomagnetic spike hit the ancient kingdom of Judah


Imagine a world in which we didn’t exchange currency, but kept track of who had what on a huge public spreadsheet, distributed across the internet. Every 10 minutes, all the transactions that took place in that slice of time are fused together into a single block. Each block includes a chain linking it to previous blocks, hence the term ‘blockchain’. The end result is a universal record book that reliably logs everything that’s ever happened via a (theoretically) tamper-proof algorithm. We don’t need to trust human bankers to tell us who owns what, because we can all see what’s written in the mathematically verified blockchain.

But Bitcoin is just one version of the blockchain. The fundamental technology has the potential to replace a much wider range of human institutions in which we use trust to reach a consensus about a state of affairs. It could provide a definitive record for property transfers, from diamonds to Porsches to original Picassos. It could be used to record contracts, to certify the authenticity of valuable goods, or to securely store your health records (and keep track of anyone who’s ever accessed them).

But there’s a catch: what about the faithful ‘execution’ of a contract? Doesn’t that require trust as well? What good is an agreement, after all, if the text is there but people don’t respect it, and don’t follow through on their obligations?

The great cryptocurrency heist



According to Zurich’s Das Magazine, which profiled Kosinski in late 2016, “with a mere ten ‘likes’ as input his model could appraise a person’s character better than an average coworker. With seventy, it could ‘know’ a subject better than a friend; with 150 likes, better than their parents. With 300 likes, Kosinski’s machine could predict a subject’s behavior better than their partner. With even more likes it could exceed what a person thinks they know about themselves.”

It had taken Kosinski and his colleagues years to develop that model, but with his methods and findings now out in the world, there was little to stop SCL Elections from replicating them. It would seem they did just that.

Where traditional pollsters might ask a person outright how they plan to vote, Analytica relies not on what they say but what they do, tracking their online movements and interests and serving up multivariate ads designed to change a person’s behavior by preying on individual personality traits. ...using 40-50,000 different variants of ad every day that were continuously measuring responses and then adapting and evolving based on that response

For Analytica, the feedback is instant and the response automated: Did this specific swing voter in Pennsylvania click on the ad attacking Clinton’s negligence over her email server? Yes? Serve her more content that emphasizes failures of personal responsibility. No? The automated script will try a different headline, perhaps one that plays on a different personality trait -- say the voter’s tendency to be agreeable toward authority figures. Perhaps: “Top Intelligence Officials Agree: Clinton’s Emails Jeopardized National Security.”

Not Just a Bubble, But Trapped in Your Own Ideological Matrix
Imagine that in 2020 you found out that your favorite politics page or group on Facebook didn’t actually have any other human members, but was filled with dozens or hundreds of bots that made you feel at home and your opinions validated? Is it possible that you might never find out?

The Rise of the Weaponized AI Propaganda Machine



Alright, many people will say this can’t scale - but it can scale down - into self-organizing small teams. Worth the read and thought.
Yet Mr Kniberg stresses that not having to ask permission does not remove the need for staff to discuss issues or bounce ideas off each other.
Because they are all in charge, workers are more motivated, he argues. Crisp regularly measures staff satisfaction, and the average is about 4.1 out of five.

No CEO: The Swedish company where nobody is in charge

Do you really need someone to tell you what to do at work?
Three years ago, Swedish software consultancy Crisp decided that the answer was no.
The firm, which has about 40 staff, had already trialled various organisational structures, including the more common practice of having a single leader running the company.

Crisp then tried changing its chief executive annually, based on a staff vote, but eventually decided collectively that no boss was needed.
Yassal Sundman, a developer at the firm, explains: "We said, 'what if we had nobody as our next CEO - what would that look like?' And then we went through an exercise and listed down the things that the CEO does."

The staff decided that many of the chief executive's responsibilities overlapped with those of the board, while other roles could be shared among other employees.
"When we looked at it we had nothing left in the CEO column, and we said, 'all right, why don't we try it out?'" says Ms Sundman.


This is a must read article for anyone interested in the future of political-economies, politics, the power of AI for the ‘less than good’. Also this is a fascinating site to follow - articles created by Science Fiction writers. There’s a 12 min video as well.
Cambridge Analytica isn’t the only company that could pull this off -- but it is the most powerful right now. Understanding Cambridge Analytica and the bigger AI Propaganda Machine is essential for anyone who wants to understand modern political power, build a movement, or keep from being manipulated. The Weaponized AI Propaganda Machine it represents has become the new prerequisite for political success in a world of polarization, isolation, trolls, and dark posts.
We have entered a new political age. At Scout, we believe that the future of constructive, civic dialogue and free and open elections depends on our ability to understand and anticipate it.

The Rise of the Weaponized AI Propaganda Machine

There’s a new automated propaganda machine driving global politics. How it works and what it will mean for the future of democracy.
“This is a propaganda machine. It’s targeting people individually to recruit them to an idea. It’s a level of social engineering that I’ve never seen before. They’re capturing people and then keeping them on an emotional leash and never letting them go,” said professor Jonathan Albright.

Albright, an assistant professor and data scientist at Elon University, started digging into fake news sites after Donald Trump was elected president. Through extensive research and interviews with Albright and other key experts in the field, including Samuel Woolley, Head of Research at Oxford University’s Computational Propaganda Project, and Martin Moore, Director of the Centre for the Study of Media, Communication and Power at Kings College, it became clear to Scout that this phenomenon was about much more than just a few fake news stories. It was a piece of a much bigger and darker puzzle -- a Weaponized AI Propaganda Machine being used to manipulate our opinions and behavior to advance specific political agendas.

By leveraging automated emotional manipulation alongside swarms of bots, Facebook dark posts, A/B testing, and fake news networks, a company called Cambridge Analytica has activated an invisible machine that preys on the personalities of individual voters to create large shifts in public opinion. Many of these technologies have been used individually to some effect before, but together they make up a nearly impenetrable voter manipulation machine that is quickly becoming the new deciding factor in elections around the world.


Google has created many open source software projects including Android - here is another gift - not open source - but as a gift. I wonder if this is possibly related to a blockchain capability - as a complement.
Spanner has provided Google with a competitive advantage in so many different markets. It underpins not only AdWords and Gmail but more than 2,000 other Google services, including Google Photos and the Google Play store. Google gained the ability to juggle online transactions at an unprecedented scale, and thanks to Spanner’s extreme form of data replication, it was able to keep its services up and running with unprecedented consistency.
Spanner could also be useful in the financial markets, allowing big banks to more efficiently track and synchronize trades happening across the planet.

Spanner, the Google Database That Mastered Time, Is Now Open to Everyone

ABOUT A DECADE ago, a handful of Google’s most talented engineers started building a system that seems to defy logic.

Called Spanner, it was the first global database, a way of storing information across millions of machines in dozens of data centers spanning multiple continents, and it now underpins everything from Gmail to AdWords, the company’s primary moneymaker. But it’s not just the size of this creation that boggles the mind. The real trick is that, even though Spanner stretches across the globe, it behaves as if it’s in one place.

Google can change company data in one part of this database—running an ad, say, or debiting an advertiser’s account—without contradicting changes made on the other side of the planet. What’s more, it can readily and reliably replicate data across multiple data centers in multiple parts of the world—and seamlessly retrieve these copies if any one data center goes down. For a truly global business like Google, such transcontinental consistency is enormously powerful.

Part of the trick is that they equipped Google’s data centers with a series of GPS receivers and atomic clocks. The GPS receivers, much like the one in your cell phone, grab the time from various satellites orbiting the globe, while the atomic clocks keep their own time. Then they shuttle their time readings to master servers in each data center. These masters constantly trade readings in an effort to settle on a common time.

A margin of error still exists, but thanks to so many readings, the masters can bootstrap a far more reliable timekeeping service. “This gives you faster-than-light coordination between two places,” says Peter Mattis, a former Google engineer who founded CockroachDB, a startup working to build an open source version of Spanner.

Google calls this timekeeping technology TrueTime, and only Google has it. Drawing on a celebrated research paper Google released in 2012, Mattis and CockroachDB have duplicated many other parts of Spanner—but not TrueTime. Google can pull this off only because of its massive global infrastructure.


This is a great article with lovely graphics describing the machine learning architecture in comparison of the regular CPU or the Graphics Processor. What is interesting as well is the insight to new metaphors of describing computation as learning. We cannot grasp a truly unknown phenomena without colonizing the experience with familiar metaphors - so when new metaphors arise we should pay attention to what types of thinking they enable. This new metaphor of computation the Intelligent Processing Unit (IPU) is a graph processor bears watching.
We have designed it to be extensible; the IPU will accelerate today’s deep learning applications, but the combination of Poplar and IPU provides access to the full richness of the computational graph abstraction for future innovation.

Inside an AI 'brain' - What does machine learning look like?

One aspect all recent machine learning frameworks have in common - TensorFlow, MxNet, Caffe, Theano, Torch and others - is that they use the concept of a computational graph as a powerful abstraction. A graph is simply the best way to describe the models you create in a machine learning system. These computational graphs are made up of vertices (think neurons) for the compute elements, connected by edges (think synapses), which describe the communication paths between vertices.

Unlike a scalar CPU or a vector GPU, the Graphcore Intelligent Processing Unit (IPU) is a graph processor. A computer that is designed to manipulate graphs is the ideal target for the computational graph models that are created by machine learning frameworks.

We’ve found one of the easiest ways to describe this is to visualize it. Our software team has developed an amazing set of images of the computational graphs mapped to our IPU. These images are striking because they look so much like a human brain scan once the complexity of the connections is revealed – and they are incredibly beautiful too.


This is a must read article for anyone interested in the Blockchain technology and the current state of Etherium. The key lesson related the the initial basic assumption that it is possible to have a ‘trustless’ system. The article provides a good analysis of the history of Etherium’s lessons in this regard. That said the blockchain remains as promising as it was in terms of a disruptive technology of distributive trust.
This is another signal - of the need for a new institution - a global Auditor General of Algorithms - to ensure a sort of ‘truth in algorithm’ - that they are doing what they say they are doing.

The great cryptocurrency heist

Blockchains don’t offer us a trustless system, but rather a reassignment of trust
It might make for good marketing copy, but the fact of the matter is that blockchain technology is larded through with trust. First, you need to trust the protocol of the cryptocurrency and/or DAO. This isn’t as simple as saying ‘I trust the maths’, for some actual human (or humans) wrote the code and hopefully debugged it, and we are at least trusting them to get it right, no? Well, in the case of The DAO, no, maybe they didn’t get it right.

Second, you have to trust the ‘stakeholders’ (including miners) not to pull the rug out from under you with a hard fork. One of the objections to the hard fork was that it would create a precedent that the code would be changeable. But this objection exposes an unmentioned universal truth: the immutability of the blockchain is entirely a matter of trusting other humans not to fork it. Ethereum Classic Classic would be no more immutable than Etherum Classic, which was no more immutable than Ethereum. At best, the stakeholders – humans all – were showing that they were more trustworthy qua humans about not forking around with the blockchain. But at the same time, they obviously could change their minds about forking at any time. In other words, if Ethereum Classic is more trustworthy, it’s only because the humans behind it are.  

Third, if you are buying into Ethereum or The DAO or any other DAO, you are being asked to trust the people who review the algorithm and tell you what it does and whether it’s secure. But those people – computer scientists, say – are hardly incorruptible. Just as you can bribe an accountant to say that the books are clean, so too can you bribe a computer scientist. Moreover, you’re putting your trust in whatever filters you applied to select that computer scientist. (University or professional qualifications? A network of friends? The testimonials of satisfied customers – which is to say, the same method by which people selected Bernie Madoff as their financial advisor.)

Finally, even if you had it on divine authority that the code of a DAO was bug-free and immutable, there are necessary gateways of trust at the boundaries of the system. For example, suppose you wrote a smart contract to place bets on sporting events. You still have to trust the news feed that tells you who won the match to determine the winner of the bet. Or suppose you wrote a smart contract under which you were to be delivered a truck full of orange juice concentrate. The smart contract can’t control whether or not the product is polluted by lemons or some other substance. You have to trust the humans in the logistics chain, and the humans at the manufacturing end, to ensure your juice arrives unadulterated.
For anyone looking for a 2 min video explanation of the Blockchain here it is

Understand the Blockchain in Two Minutes

Over the past decade, an alternative digital paradigm has slowly been taking shape at the edges of the internet.

This new paradigm is the blockchain. After incubating through millions of Bitcoin transactions and a host of developer projects, it is now on the tips of tongues of CEOs and CTOs, startup entrepreneurs, and even governance activists. Though these stakeholders are beginning to understand the disruptive potential of blockchain technology and are experimenting with its most promising applications, few have asked a more fundamental question: What will a world driven by blockchains look like a decade from now?


There is a lot that has been written about video games and their impact on players. For many, however, video games are also works of art - like photography or films - maybe even more important than are in any previous art media.

Video Games Do Guilt Better Than Any Other Art

The idea that motion pictures can be works of art has been around since the 1920s, and it hasn’t really been disputed since. It’s easy to see why—cinema shares characteristics with theater in terms of acting, direction, music, set design, narrative, and so on. Now we have whole academic departments dedicated to film appreciation, to understanding the emotional and intellectual responses—deep feelings of awe and reverence, among others—that movies can elicit.

But video games aren’t assumed to be as artistic as cinema or theater, if it all. In 2010, for instance, the late film critic Roger Ebert wrote an essay titled, “Video Games Can Never Be Art.” But with the increasing sophistication, and variety, of video games today, it’s becoming more and more clear that they are forms of art; or, at least, they evoke many of the same intellectual and emotional responses that artworks do. What’s more, creating large-scale titles is like creating big-budget films or operas, since they require huge teams of people. An enormous amount of the cost of a big-budget video game is paid to people the industry classifies as “artists.” (When their jobs have such titles as set and lighting design, music composition and performance, acting, animating, and painting, what else should we call them?)

There have been many arguments against views like Ebert’s, and I won’t rehash them here. But perhaps it’s not enough to say, as the philosopher Aaron Smuts does, that video games are on equal artistic footing with any other so-called art. It might be that video games can actually do more as art than other forms.
I’m talking about guilt.


This is a fascinating and very important article - one of a number of recent articles discussing livelihood on social media platforms. Reading this article a little bit beneath the surface - beyond the ‘scandal’ (in the world of humor and satire - we must tread with care -between vigilance of hate-speech and the role of art to make us reflect seriously) and extrapolating to any other social media platform - highlights a need for a new institution - one addressing ‘creator rights’ that would constrain or make social media platforms more accountable to democratic principles. Livelihood in the emerging digital environment needs to be included in a digital charter of citizen rights.

YouTube’s Monster: PewDiePie and His Populist Revolt

Felix Kjellberg, known to his fans as PewDiePie, is by far YouTube’s biggest star. His videos, a mix of video-game narration, humorous rants and commentary, have cumulatively been viewed billions of times, and more than 53 million people subscribe to his channel. He has been called “the king of YouTube” and countless variations thereon, and he has remained unchallenged on that perch for years, making millions of dollars and leveraging his popularity into outside ventures.

But Monday night, The Wall Street Journal reported that the Disney-owned Maker Studios, a longtime partner of Kjellberg’s, would no longer have anything to do with him; later, YouTube announced that it was canceling a show developed with Kjellberg, and removing his channel from its lucrative “Google Preferred” advertising program. At issue was a series of recent comedy videos….

With more than a billion users, YouTube has become not merely a platform but almost a kind of internet nation-state: the host of a gigantic economy and a set of cultures governed by a new and novel sort of corporation, sometimes at arm’s length and other times up close. It’s a system Kjellberg has spent recent months antagonizing in a broader and less-inflammatory way, even as he continued to thrive within it. He bemoaned its structure and the way it had changed; he balked at its limits and took joy in causing offense and flouting rules. Over time, he grew into an unlikely, disorienting and insistently unserious political identity: He became YouTube’s very own populist reactionary.


In a similar stream of thinking.
“Nation-state hacking has evolved into attacks on civilians in times of peace,” said Smith at the RSA Conference in San Francisco, echoing the language of the Geneva Convention. “We need to call on the world’s governments to come together [as] they came together in 1949 in Switzerland.” Smith, who is also Microsoft's chief legal officer, has recently lobbied for legal reforms to update privacy and security protections for the Internet era

Do We Need a Digital Geneva Convention?

Microsoft calls for an international treaty to prevent companies and citizens from getting tangled up in nation-state cyberattacks.
The Geneva Convention, signed by war-weary nations in August 1949, now binds 196 countries to protect civilians in war zones. Microsoft’s president, Brad Smith, argues that the U.S. and other countries now need to draw up a digital equivalent to protect civilians and companies caught in the crossfire of constant cyberwar.

In recent years, computing and security companies have uncovered or been the victims of malware and network attacks that appear linked with military or intelligence agencies. Smith told an audience at the world’s largest security conference Tuesday that international diplomacy is needed to mitigate the negative effects on private companies and citizens.


Fascinating that games can induce guilt but employers readily continue to employ surveillance systems to control their workers. This is not quite the same as the use of sociometric badges used with employee consent.

Your Cubicle Has Ears—and Eyes, and a Brain

Sensors and AI can keep tabs on employees better than any boss.
Employers have long wanted to know how their workers spend their time. New office surveillance technology is now making the task far easier.

Bloomberg reports that an increasing number of companies are outfitting offices with sensors to keep track of employees. These sensors are hidden in lights, on walls, under desks—anywhere that allows them to measure things like where people are and how much they are talking or moving.

The raw data is just the beginning. New Scientist recently reported that a startup called StatusToday uses software to crunch information on everything from key card swipes to what applications people are using on their computers to understand how employees—and the business as a whole—operate.

Advocates suggest that insights from these kinds of initiatives can streamline companies and spot potential problems before they happen. Perhaps only two-thirds of desks get used at any moment, so the company can downsize the amount of office space they lease. Or maybe an employee looks at a lot of sensitive data and schedules a large number of external meetings, so the system flags them as a potential security risk. These are, after all, the problems that keep senior management awake at night.
Of course, the such schemes can also be read as creepy, Big Brother-style surveillance.


And surveillance of our systems is becoming ever more inadequate - a metaphor perhaps of any form of ‘activism’ or nefarious intentions.
The simplest advice for online safety comes via cybersecurity journalist Brian Krebs: First, if you didn’t go looking for it, don’t install it. Second, if you installed it, update it. Third, if you no longer need it, get rid of it! Mostly, use common sense: You wouldn’t eat a piece of candy off the ground. Yet in 2008, a U.S. soldier sparked one of the largest data breaches in military history by using a USB stick he found in the parking lot outside his base.

You Can’t Depend on Antivirus Software Anymore

Malware has become too sophisticated.
In 2005, Panda Software reported that a new strain of malware was discovered every 12 minutes. In 2016, the cybersecurity company McAfee says it found four every second.

And those were just the strains the companies could detect. For malware—the umbrella term for parasitic software like viruses, worms, and Trojans that infiltrate and interfere with computer functions—hasn’t only proliferated: It’s evolved to better evade detection.

Faced with this tsunami of sophisticated malware, antivirus software like McAfee, once practically synonymous with personal cybersecurity, has struggled to keep pace. In 2014, a senior vice president at Symantec (the company that created McAfee competitor Norton Antivirus) went so far as to publicly say he thought that antivirus software was “dead.” At the time, he estimated that the technology only caught about 45 percent of cyberattacks.


The tipping point has been passed - the question is will the US keep the pace of progress despite efforts by incumbents.
“What these numbers tell you is that the solar industry is a force to be reckoned with,” said Abigail Ross Hopper, SEIA’s president and CEO. “Solar's economically winning hand is generating strong growth across all market segments nationwide, leading to more than 260,000 Americans now employed in solar.”

US Solar Market Grows 95% in 2016, Smashes Records

In its biggest year to date, the United States solar market nearly doubled its annual record, topping out at 14,626 megawatts of solar PV installed in 2016.

This represents a 95 percent increase over the previous record of 7,493 megawatts installed in 2015. GTM Research and the Solar Energy Industries Association (SEIA) previewed this data in advance of their upcoming U.S. Solar Market Insight report, set to be released on March 9.

For the first time ever, U.S. solar ranked as the No. 1 source of new electric generating capacity additions on an annual basis. In total, solar accounted for 39 percent of new capacity additions across all fuel types in 2016.


This is may be a game changer for the hydrogen economy - a way to create fuels cells for homes, building, cars. Another forward move in a new energy geopolitics.

Four-stroke engine cycle produces hydrogen from methane and captures CO2

When is an internal combustion engine not an internal combustion engine? When it's been transformed into a modular reforming reactor that could make hydrogen available to power fuel cells wherever there's a natural gas supply available.

By adding a catalyst, a hydrogen separating membrane and carbon dioxide sorbent to the century-old four-stroke engine cycle, researchers have demonstrated a laboratory-scale hydrogen reforming system that produces the green fuel at relatively low temperature in a process that can be scaled up or down to meet specific needs. The process could provide hydrogen at the point of use for residential fuel cells or neighborhood power plants, electricity and power production in natural-gas powered vehicles, fueling of municipal buses or other hydrogen-based vehicles, and supplementing intermittent renewable energy sources such as photovoltaics.

Known as the CO2/H2 Active Membrane Piston (CHAMP) reactor, the device operates at temperatures much lower than conventional steam reforming processes, consumes substantially less water and could also operate on other fuels such as methanol or bio-derived feedstock. It also captures and concentrates carbon dioxide emissions, a by-product that now lacks a secondary use—though that could change in the future.


This is a short article discussing some further progress in understanding autoimmune conditions, genes and microbial profiles. Worth the read.

The very microbes that helped us evolve now make us sick

Between the mid-1990s and the mid-2000s alone, the likelihood of having a classmate with a food allergy increased by 20 per cent in the United States. In fact, over the past five decades, the incidence of all allergies and autoimmune diseases – caused by your body attacking itself – has skyrocketed. What could explain our sudden hypersensitivity to our surroundings and ourselves? Since evolution operates on the timescale of millennia, the culprits lie not in our genes but somewhere within our environment.

One thing that has changed in public health is our awareness of germs and how they spread. In response to that insight, over the past half-century our implementation of hygiene practices has spared us from debilitating infections and enormous human misery. But the new vigilance might have altered the development of our immune system, the collection of organs that fight infections and internal threats to our health.

So what has changed? In short, it’s the standard for what constitutes a good microbe versus a bad one. ‘Take bacterial species that increase nutrient absorption from food,’ Medzhitov says. These were immensely beneficial at a time where you had to go days without eating. Today in the parts of the world with an overabundance of food, having such bacteria in your intestine contributes to obesity. ‘Microbes that cause intestinal inflammation are another example of what we call bad microbes because they induce [detrimental immune] responses. But in the past, these microbes could have protected you from intestinal pathogens,’ he adds.    


Here’s some great news about Tuberculosis.

Two new drug therapies might cure every form of tuberculosis

Tuberculosis, the world’s leading infectious killer, may have finally met its match. Two new drug therapies may be able to cure all forms of tuberculosis – even the ones most difficult to treat.
“We will have something to offer every single patient,” says Mel Spigelman, president of the TB Alliance, the organisation coordinating trials of the two treatments. “We are on the brink of turning TB around.”

It presently takes six months of drug treatment to cure ordinary TB, and two years to cure people whose infections are resistant to drugs. People may need to take up to 20 tablets a day, plus injections.
Together, the new treatments, called BPaMZ and BPaL, could make treating TB much simpler and more effective.

BPaMZ involves taking four drugs once a day. Trials carried out in 240 people across 10 countries in Africa suggest that it cures almost all cases of ordinary TB in four months, and most people with drug-resistant TB in about six months. In the majority of cases, the TB bacterium had disappeared from sputum within two months.
“The alliance has never before seen such rapid action against TB bacteria,” says Spigelman.

Meanwhile, BPaL, a therapy that involves taking three drugs once a day, has so far cured 40 of 69 patients with “extremely-drug-resistant TB” – the most difficult form to treat. What’s more, it achieved this within six months. The 29 remaining participants in this trial are still to be assessed.
The TB Alliance says that BPaMZ has the potential to treat 99 per cent of people who catch TB each year, while BPaL could treat the remainder.


This is still in the ‘promise’ stage but given the speed of our domestication of DNA - could we see Mammoths by 2020?
“Our aim is to produce a hybrid elephant-mammoth embryo,” said Prof George Church. “Actually, it would be more like an elephant with a number of mammoth traits. We’re not there yet, but it could happen in a couple of years.”

Woolly mammoth on verge of resurrection, scientists reveal

Scientist leading ‘de-extinction’ effort says Harvard team could create hybrid mammoth-elephant embryo in two years
The woolly mammoth vanished from the Earth 4,000 years ago, but now scientists say they are on the brink of resurrecting the ancient beast in a revised form, through an ambitious feat of genetic engineering.

Speaking ahead of the American Association for the Advancement of Science (AAAS) annual meeting in Boston this week, the scientist leading the “de-extinction” effort said the Harvard team is just two years away from creating a hybrid embryo, in which mammoth traits would be programmed into an Asian elephant.


While we all accept the complexity of natural systems that are instrumental to enabling living systems to emerge and evolve - it seems that every year that complexity becomes … well more complex.

Astonishing geomagnetic spike hit the ancient kingdom of Judah

If this were to happen again today, the electrical grid could be a smoking ruin.
Earth's geomagnetic field wraps the planet in a protective layer of energy, shielding us from solar winds and high-energy particles from space. But it's also poorly understood, subject to weird reversals, polar wandering, and rapidly changing intensities. Now a chance discovery from an archaeological dig near Jerusalem has given scientists a glimpse of how intense the magnetic field can get—and the news isn't good for a world that depends on electrical grids and high-tech devices.

In a recent paper for Proceedings of the National Academy of Sciences, an interdisciplinary group of archaeologists and geoscientists reported their discovery. They wanted to analyze how the planet's geomagnetic field changes during relatively short periods, and they turned to archaeology for a simple reason. Ancient peoples worked a lot with ceramics, which means heating clay to the point where the iron oxide particles in the dirt can float freely, aligning themselves with the Earth's current magnetic field.

What they found was startling. Sometime late in the 8th century BCE, there was a rapid fluctuation in the field's intensity over a period of about 30 years—first the intensity increased to over 20 percent of baseline, then plunged to 27 percent under baseline. Though the overall trend at that time was a gradual decline in the fields' intensity similar to what we see today, this spike was basically off the charts.

Thursday, February 16, 2017

Friday Thinking 17 Feb. 2017

Hello all – Friday Thinking is a humble curation of my foraging in the digital environment. My purpose is to pick interesting pieces, based on my own curiosity (and the curiosity of the many interesting people I follow), about developments in some key domains (work, organization, social-economy, intelligence, domestication of DNA, energy, etc.)  that suggest we are in the midst of a change in the conditions of change - a phase-transition. That tomorrow will be radically unlike yesterday.

Many thanks to those who enjoy this.
In the 21st Century curiosity will SKILL the cat.
Jobs are dying - work is just beginning.

“Be careful what you ‘insta-google-tweet-face’”
Woody Harrelson - Triple 9


Content
Quotes:


Articles:
First Gene Drive in Mammals Could Aid Vast New Zealand Eradication Plan



At its height back in 2000, the U.S. cash equities trading desk at Goldman Sachs’s New York headquarters employed 600 traders, buying and selling stock on the orders of the investment bank’s large clients. Today there are just two equity traders left.


Automated trading programs have taken over the rest of the work, supported by 200 computer engineers. Marty Chavez, the company’s deputy chief financial officer and former chief information officer, explained all this to attendees at a symposium on computing’s impact on economic activity held by Harvard’s Institute for Applied Computational Science last month.


The experience of its New York traders is just one early example of a transformation of Goldman Sachs, and increasingly other Wall Street firms, that began with the rise in computerized trading, but has accelerated over the past five years, moving into more fields of finance that humans once dominated. Chavez, who will become chief financial officer in April, says areas of trading like currencies and even parts of business lines like investment banking are moving in the same automated direction that equities have already traveled.


Today, nearly 45 percent of trading is done electronically, according to Coalition, a U.K. firm that tracks the industry. In addition to back-office clerical workers, on Wall Street machines are replacing a lot of highly paid people, too.


Goldman Sachs has already begun to automate currency trading, and has found consistently that four traders can be replaced by one computer engineer, Chavez said at the Harvard conference. Some 9,000 people, about one-third of Goldman’s staff, are computer engineers.

Goldman Embraces Automation, Masters of the Universe Are Threatened



...the emergence of low-cost computers and networking appeared to augur a peer-to-peer, fluid, and more open economic landscape, one where we all step off the industrial-age, punch-the-clock treadmill and work in our own time, collaboratively, on creative pursuits, from home, in our underwear. Instead, we’re getting an exacerbation of some of extractive corporatism’s worst effects: joblessness, disenfranchisement, wealth disparity, corporate lethargy, artificial growth, and financialization.


Why aren’t we getting new, digitally enabled forms of community currency, worker-owned businesses, networked cooperatives, and peer-to-peer marketplaces? It turns out it is not because they don’t work; it’s simply because there are entrenched powers and limited visions preventing their rise. They find it hard to see digital technology as anything other than an investment opportunity. A company is not a provider of goods or services, but a “disruptor” capable of overturning an existing marketplace and generating 100x returns to the early shareholders. It doesn’t matter what the company does, if anything, after that.


The rules of capitalism were invented by human beings, at particular moments in history, with particular goals and agendas. It’s like a computer program, with accumulated lines of code written by developers throughout history with specific functions in mind. By refusing to acknowledge this, we end up incapable of getting beneath the surface. We end up transacting, and living, at the mercy of a system—of a medium, really.

Silver Lining of Anti-Globalism Might be Creation of a True Digital Economy




Tim Wu, a professor at Columbia Law School and author of The Attention Merchants, says it's as though Facebook were an industrial park. Users started setting up offices in the park, using the roads to travel, treating it like a public utility. But legally, it's private. So when Facebook shuts off the road that goes to your shop, or puts in a new toll, he says, "That's it, you're done."


Two very different people — one is a meme-maker in Florida, the other an investigative journalist from Zimbabwe — got stopped in their tracks as they were doing their work on Facebook, because of the company's decisions and refusal to talk, human-to-human. That caused them tangible harm. Their stories illustrate how much Facebook controls people's access to the online world, and how opaque the company is about this power.

Building, And Losing, A Career On Facebook




Unfortunately, whether they are running corporations or foreign ministries or central banks, some of the best minds of our era are still in thrall to an older way of seeing and thinking. They are making repeated misjudgments about the world. In a way, it’s hard to blame them. Mostly they grew up at a time when the global order could largely be understood in simpler terms, when only nations really mattered, when you could think there was a predictable relationship between what you wanted and what you got. They came of age as part of a tradition that believed all international crises had beginnings and, if managed well, ends.


This is an important distinction: the idea that we need to be gardeners instead of craftsmen. When we are merely creating something we have a sense of control; we have a plan and an end state. When the shelf is built, it's built.


Being a gardener is different. You have to prepare the environment; you have to nurture the plants and know when to leave them alone. You have to make sure the environment is hospitable to everything you want to grow (different plants have different needs), and after the harvest you aren’t done. You need to turn the earth and, in essence, start again. There is no end state if you want something to grow.

A Cascade of Sand: Complex Systems in a Complex Time




When the history of the 21st century is written, we’ll see that by 2017 the inflection point in the global energy rebuild had already occurred. We’ll see the new energy economy was just the next stage of the the larger technology transformation obviously well underway.
We’ll see that the energy revolution of the next 20 years looked a lot like the Internet revolution of the last 20 years.

Renewables are no longer ‘alternative.’ Fossil fuels are ‘legacy.’



This is an exciting signal of the potential re-imagining of a 20th century organization into a 21st century institution - a civil liberties watchdog for the digital environment.
Still: a 97-year-old nonprofit corporation doing inside a startup factory? It’s a move that has raised eyebrows among some ACLU supporters, who worry that the organization’s embrace of Silicon Valley could warp its values. “I wish I was excited [about] this,” tweeted Laura Weidman Powers, CEO of Code 2040, a nonprofit that seeks to create opportunities for black and Latino workers in the tech industry. “But I’m nervous [because] principles of tech growth have not historically been inclusive or benefitted all.”

How the ACLU became Silicon Valley’s favorite startup

The 97-year-old organization just joined the incubator that gave us Airbnb and Dropbox. Now what?
In the wake of President Donald Trump banning immigration from seven majority-Muslim countries, the American Civil Liberties Union recorded $24 million in online donations over a single weekend.


Silicon Valley has historically been wary of politics, but Trump’s executive order spurred a series of large donations. Lyft donated $1 million. Twitter employees donated $1.59 million. Googlers raised $4 million to be divided among the ACLU and three nonprofits that support immigrants and refugees. Google Ventures made a separate donation of undisclosed size. “It’s the most important investment we’ll make all year,” David Krane, the firm’s managing partner, told portfolio companies at a private dinner last week.


At more than 750,000 members, the ACLU is hardly a fringe group. Founded in 1920, it first came to fame during the Scopes Trial, in which the group defended a Tennessee high school teacher who was prosecuted for teaching human evolution. It prominently opposed the internment of Japanese Americans during World War II and racial segregation in public schools during the civil rights movement.


In some ways, ACLU will be like any other nonprofit in Y Combinator. According to the ACLU, it’s getting a $200,000 donation. It will also get access to Y Combinator’s alumni network, which is lining up to offer its support, Altman said. “One of the cool things has been that many big YC companies have said whatever we can do — free services, discounts — multiply that by 10, [and that’s] what we’ll do for the ACLU,” Altman said. “Payments processing, [web] hosting, help with designing the payments flow and donations flow. We want to do that.”


In other ways, though, it will be different. The ACLU isn’t sending representatives to Silicon Valley to live and work with the other startups in the batch. Instead, Y Combinator will send advisers to the organization’s headquarters in New York City, Altman said — an unusual arrangement for the incubator, but not the first time it has worked with a remote organization.


Other details are still being worked out — what metric the ACLU might try to improve during its time in the accelerator, for instance.


This is another landmark in a long history of human relationship with night - from domesticating fire, to electricity, to television and now the Internet.
More surprising is that it takes about 16 years on average for Internet use to saturate in any given country. That’s significantly faster than other technologies that have revolutionized societies, such as steam power, which took about 100 years, and electrification, which took about 60 years.

The Trillion Internet Observations Showing How Global Sleep Patterns Are Changing

The way we use the Internet is beginning to reveal human behavior patterns on a previously unimaginable scale.
In 1995, some 40 million people all over the world were connected to the Internet. By 2000 that had grown to around 400 million, and by 2016 it reached 3.5 billion. That means almost half the global population is connected to a single technology.


That’s an extraordinary statistic and one that raises an interesting possibility. With so many people connected in this way, it should become possible to use this technology as a kind of demographic sensor that measures human behavior on an almost unimaginable scale.


Today, Klaus Ackermann at the University of Chicago and a couple of pals say they have done just this by studying how devices connected to, and disconnected from, the Internet between 2006 and 2013. They have done this on a global scale at a time resolution of every 15 minutes to produce a truly mind-boggling number of observations—one trillion of them.
So what does this enormous data set reveal about humanity?

This is not yet proven nor ready for primetime - but it may well be worth watching - disrupting again - the speed of our wifi networks.

This New Technology Can Send Data 10 Times Faster Than 5G

What are called the 5G or fifth-generation mobile networks are set to become available by 2020, with promises of improved connections and faster data transfer rates. But, what if we could get speeds faster than 5G before 2020? That’s the subject of a paper that was delivered this week at the International Solid-State Circuits Conference (ISSCC) held in San Francisco, California.


The paper talks about a terahertz (THz) transmitter developed by the National Institute of Information and Communications Technology, Panasonic Corporation, and Hiroshima University. This transmitter operates using a frequency range from 290 GHz to 315 GHz and is capable of transmitting digital data at a rate of 105 gigabits per second — which is a communication speed that’s at least 10 times as fast as 5G networks. The transmitter uses a frequency that falls within a currently unallocated range of 275 GHz to 450 GHz. Its use will be covered in the 2019 World Radiocommunication Conference (WRC) under the International Telecommunication Union Radiocommunication Section (ITU-R).


The researchers were able to reach the speed levels described in the paper by using quadrature amplitude modulation (QAM), which enhances the speed of a wireless link in the 300GHz band. These researchers managed to, for the first time, reach speeds exceeding 100 gigabits per second with an integrated circuit-based transmitter.

One of the most popular science fiction themes is the rise of AI against humanity. It has become a salient meme in many conversations about the future. This article is the result of a conference with the aim of creating a set of guiding principles. The conference attendees include many of the who’s who in the AI world.

ASILOMAR AI PRINCIPLES

These principles were developed in conjunction with the 2017 Asilomar conference
Artificial intelligence has already provided beneficial tools that are used everyday by people around the world. Its continued development, guided by the following principles, will offer amazing opportunities to help and empower people in the decades and centuries ahead. The 23 principles are divided into three categories: Research Issues; Ethics and Values; Longer-term Issues

This is interesting - for work that humans will still engage in, AI may become their coach and mentors - maybe our personal AI-ssistant will be more like Batman’s Alfred - butler and mentor.
call centers do not want to replace phone workers, but they are keen to improve the way they operate. “Humans are social beings,” he says. “We engage with each other for emotional reasons, and we want somebody to help us, to counsel us.”
Feast founded Cogito, in 2007, with Sandy Pentland, a professor in the MIT Media Lab who specializes in studying human dynamics. The company originally developed its technology with funding from DARPA as a way to detect a person’s mental state using his or her speech.

Socially Sensitive AI Software Coaches Call-Center Workers

Customer-service reps are getting real-time coaching from software that has learned to detect problems in a conversation.
Some call-center workers are now receiving real-time coaching from software that analyzes their speech and the nature of their dialogue interactions with customers. As they are talking to someone the software might recommend that they talk more slowly or interrupt less often, or warn that the person on the other end of the line seems upset.


This gives us a fascinating glimpse of how AI and humans might increasingly work together in the future. Plenty of routine work is becoming automated in call centers and other back office settings, but real human interaction seems likely to resist automation for a long while yet. Even so, AI software may change the way people interact with customers by serving in an advisory capacity.


The call-center software is supplied by Cogito, a company based in Boston. Its software automatically assesses the dynamics of a conversation, and has been trained to recognize certain pertinent characteristics. Rather than the substance of a conversation, it analyzes the raw audio. “Conversation is like a dance,” says Josh Feast, CEO of Cogito. “You can tell whether people are in sync, and it turns out this is a much better measure than language.”

The Internet-of-Things is getting closer - the visual on this page is worth the view. What is misdirected with the term ‘Internet-of-Things’ is an evocation of ‘things’ - a focus on nodes - rather than the emergence of a digital cloud or atmosphere through which we must navigate or wayfind.
At the conference, they described micro mote designs that use only a few nanowatts of power to perform tasks such as distinguish the sound of a passing car and measuring temperature and light levels. They showed off a compact radio that can send data from the small computers to receivers 20 meters away

Millimeter-Scale Computers: Now With Deep Learning Neural Networks on Board

Computer scientist David Blaauw pulls a small plastic box from his bag. He carefully uses his fingernail to pick up the tiny black speck inside and place it on the hotel café table. At one cubic millimeter, this is one of a line of the world’s smallest computers. I had to be careful not to cough or sneeze lest it blow away and be swept into the trash.


Blaauw and his colleague Dennis Sylvester, both IEEE Fellows and computer scientists at the University of Michigan, were in San Francisco this week to present ten papers related to these “micro mote” computers at the IEEE International Solid-State Circuits Conference (ISSCC). They’ve been presenting different variations on the tiny devices for a few years.


Their broader goal is to make smarter, smaller sensors for medical devices and the internet of things—sensors that can do more with less energy. Many of the microphones, cameras, and other sensors that make up eyes and ears of smart devices are always on alert, and frequently beam personal data into the cloud because they can’t analyze it themselves. Some have predicted that by 2035, there will be 1 trillion such devices. “If you’ve got a trillion devices producing readings constantly, we’re going to drown in data,” says Blaauw. By developing tiny, energy efficient computing sensors that can do analysis on board, Blaauw and Sylvester hope to make these devices more secure, while also saving energy.


Another micro mote they presented at the ISSCC incorporates a deep-learning processor that can operate a neural network while using just 288 microwatts.

This is definitely a signal that more such plants are on their way.

Millions of Tesla battery cells are powering thousands of LA homes

396 Powerpacks can power 15,000 homes for four hours
An enormous Tesla-installed power storage facility is up and running at Southern California Edison’s Mira Loma substation in Ontario, California. The facility, announced last fall, holds enough energy to power 15,000 homes for four hours — 80 megawatt hours of electricity with a peak output of 20 megawatts.


It’s designed to reduce the need for “peaker plants” — electricity generation facilities that run when electricity demands are particularly high, such as on a hot afternoon when air conditioners are running full tilt. They’re expensive to install and maintain, especially when in some areas they might only be used for a few hours a day — or even a year.


The 396 Powerpacks that Tesla installed (it acted as its own general contractor) for SCE were all assembled at the company’s Gigafactory in Nevada. Though 80 megawatt hours of batteries might seem like a lot, it’s the same amount of battery capacity that the company puts into its cars in just three or four days of production.


The SCE facility at Mira Loma has 396 Powerpacks, each with 16 pods of batteries inside. Each pod has 12 bricks of cells, and each brick has 85 battery cells. Add ‘em all up and it’s 6,462,720 individual “2170” battery cells, so named because they’re 21 x 70mm cylinders.

Here’s another weak signal of potentially looming battery disruptions - once energy storage is inexpensive - then zero-marginal cost energy will accelerate even more.

Harvard’s New Battery Can Run For More Than a Decade

FLOW BATTERIES
Researchers have discovered a way to make the promising flow battery much more practical. Flow batteries store energy in liquid-filled tanks. Prior to this most recent discovery, flow batteries, after a number of charge-discharge cycles, would suffer from rapid storage capacity degradation.


In order to overcome the degradation hurdle, the researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) modified the structure of molecules in the solution to make them water soluble. This allowed for the electrolytes to be dissolved in neutral water, creating a battery that only loses one percent of its storage capacity every 1000 cycles. According to the official press release, the battery is able to run for ten years with only a minimum amount of upkeep.


Unlike other battery liquids, the solution in this new flow battery is both non-toxic as well as non-corrosive. Spilling it on skin or on the floor causes no injury or property damage.

This is ready for primetime - but it’s another signal of the rapid development of all sorts of robotics. Some of the images are worth the view.

This bipedal robot could deliver your packages one day

Bipedal robots have been a tough ask for engineers. Creating a bot that’s steady, self-balancing, and able to adapt to uneven terrain (one of the main advantages of going bipedal in the first place!) is a tough ask. But, as this newly unveiled bot from Agility Robotics proves, we’re getting good at it.


The bot’s name is Cassie, and, as reported by IEEE Spectrum, it comes from a fine lineage of bipedal robots. Agility Robotics is a spinoff company from Oregon State University, and the firm’s researchers previously created the ATRIAS robot. (You may remember ATRIAS from a video of it playing a slightly one-sided game of dodgeball.)


“ATRIAS was the first machine to demonstrate human-like gait dynamics and implement spring-mass walking, but it was not a practical machine for any use other than science demonstration.” Agility Robotics co-founder Jonathan Hurst told Spectrum. (“Spring-mass walking” basically uses the elasticity of springs to create a passive mechanism mimicking human muscles.)

The self-driving car, the autonomous drone and soon to a harbor near you maybe a self-driving ship.
"The development will start in a few countries, and these flag states will give the vessel permission to operate before we have international regulations in place."
A spokesman for the international maritime union Nautilus said: "The pace of change is a challenge to safety and there are also many unanswered questions about the legal implications of the way in which operational and management responsibilities are being taken away from ships’ staff.
International shipping expert Jonathan Moss, from law firm DWF, said: "The maritime industry as a whole may suffer in terms of employment levels.

Rolls-Royce plans to launch crewless ships by 2020

Tugboats and ferries are being developed first, with international cargo ships expected to follow later.
The engineering giant is working with government-backed groups across northern Europe on the autonomous vessels.


The company estimates that the move could cut sea transport costs by as much as 20%.
Rolls-Royce vice president of innovation Oskar Levander said tugboats and ferries will be developed first, ahead of cargo vessels which will sail across international waters.

The self-driving car becomes the key enabler of the future we’ve all grown up with - the flying car.
“They just need to press a button and then it vertically takes off, flies from point A to point B, and lands.”

Dubai To Put Autonomous Taxi Drones In The Skies 'This Summer'

When the ruling family decrees that a quarter of all journeys in a city state will be autonomous by 2030, someone somewhere is obliged to make that start happening as soon as possible.


In Dubai, that person is Mattar Al Tayer, chairman of the city’s Road and Transport Authority. He said Monday that he hopes Dubai will have autonomous taxi drones zipping around its skyline this summer. Actual drones that people can sit inside without fearing for their lives.


The flying taxis are being manufactured by Chinese drone-making firm EHang and can carry a person weighing up to 100 kilograms (about 220 pounds) along with a small suitcase. Passengers don’t need to learn how to fly the drones, EHang's co-founder Derrick Xiong told FORBES staff writer Aaron Tilley in an interview this time last year.

Somehow, I’m a bit skeptical of Ford’s strategy - seems a retreat into an old business model than a step into the 21st Century. While is supports the looming emergence of a change in the conditions of change as far as transportation and mass transit - it seems to be wanting to compete with a closed proprietary model rather than embracing a more robust open-source model that could make all AI and transportation safer, more agile and evolvable faster.

Ford spending $1 billion on self-driving artificial intelligence

Ford announced an investment in artificial-intelligence company Argo AI to foster development of its self-driving car technology.
Ford announced today a $1 billion investment in machine-learning startup Argo AI. Through the agreement, Argo AI will work exclusively for Ford on the software brains to enable self-driving.


Ford previously announced it will offer a self-driving car by 2021, although it would likely be limited to urban environments and be used by ride-hailing services as a kind of robo-taxi.
Pittsburgh, Pennsylvania-based Argo AI is a new company dedicated to developing a software system to guide self-driving cars. CEO Bryan Salesky said of the investment that it would allow Argo AI to recruit the kind of talent needed to develop these systems.


Ford CEO Mark Fields said, "For accounting purposes, Argo AI will be a subsidiary of Ford, but have a lot of independence. Its sole focus over the next five years will be developing self-driving software for Ford vehicles."

Here’s a fascinating experiment bringing AI and robotics together - this could transform the popular reality show - Robot Wars.

Google’s DeepMind pits AI against AI to see if they fight or cooperate

Unsurprisingly, they do both
What happens if one AI’s aims conflict with another’s? Will they fight, or work together?
Google’s AI subsidiary DeepMind has been exploring this problem in a new study published today. The company’s researchers decided to test how AI agents interacted with one another in a series of “social dilemmas.” This is a rather generic term for situations in which individuals can profit from being selfish — but where everyone loses if everyone is selfish. The most famous example of this is the prisoner’s dilemma, where two individuals can choose to betray one another for a prize, but lose out if both choose this option.


As explained in a blog post from DeepMind, the company’s researchers tested how AI agents would perform in these sorts of situations, by dropping them into a pair of very basic video games.

This article is interesting on several levels - even with cars become electric - they still will rely on fossil fuels to make tires. Except this innovation can transform that. Also this is important in understanding how harnessing microbial agents we may transform how we manufacture many things.
"Our team created a new chemical process to make isoprene, the key molecule in car tires, from natural products like trees, grasses, or corn," said Paul Dauenhauer, a University of Minnesota associate professor of chemical engineering and materials science and lead researcher of the study. "This research could have a major impact on the multi-billion dollar automobile tires industry."

Researchers invent process to produce renewable car tires from trees, grass

A team of researchers, led by the University of Minnesota, has invented a new technology to produce automobile tires from trees and grasses in a process that could shift the tire production industry toward using renewable resources found right in our backyards.


Conventional car tires are viewed as environmentally unfriendly because they are predominately made from fossil fuels. The car tires produced from biomass that includes trees and grasses would be identical to existing car tires with the same chemical makeup, color, shape, and performance.
The technology has been patented by the University of Minnesota and is available for licensing through the University of Minnesota Office of Technology Commercialization.


The new study is published by the American Chemical Society's ACS Catalysis, a leading journal in the chemical and catalysis sciences. Authors of the study, include researchers from the University of Minnesota, University of Massachusetts Amherst, and the Center for Sustainable Polymers, a National Science Foundation-funded center at the University of Minnesota.

Bringing healthcare to the world involves the ability to diagnose problems - here’s a significant leap forward toward an essentially costless diagnostic method.
"Enabling early detection of diseases is one of the greatest opportunities we have for developing effective treatments," Esfandyarpour said. "Maybe $1 in the U.S. doesn't count that much, but somewhere in the developing world, it's a lot of money."

Scientists develop 'lab on a chip' that costs one cent to make

Researchers at the Stanford University School of Medicine have developed a way to produce a cheap and reusable diagnostic "lab on a chip" with the help of an ordinary inkjet printer.


At a production cost of as little as 1 cent per chip, the new technology could usher in a medical diagnostics revolution like the kind brought on by low-cost genome sequencing, said Ron Davis, PhD, professor of biochemistry and of genetics and director of the Stanford Genome Technology Center.


A study describing the technology will be published online Feb. 6 in the Proceedings of the National Academy of Sciences. Davis is the senior author. The lead author is Rahim Esfandyarpour, PhD, an engineering research associate at the genome center.


The inexpensive lab-on-a-chip technology has the potential to enhance diagnostic capabilities around the world, especially in developing countries. Due to inferior access to early diagnostics, the survival rate of breast cancer patients is only 40 percent in low-income nations—half the rate of such patients in developed nations. Other lethal diseases, such as malaria, tuberculosis and HIV, also have high incidence and bad patient outcomes in developing countries. Better access to cheap diagnostics could help turn this around, especially as most such equipment costs thousands of dollars.

The gene drive technology derived from CRISPR has been a controversial news item for a while - Here’s another signal of its immanent deployment.

First Gene Drive in Mammals Could Aid Vast New Zealand Eradication Plan

Evolution-warping technology applied to mice is a step toward “synthetic” species conservation.
Scientists working in coördination with a U.S. conservation group say they’ve established an evolution-warping technology called a “gene drive” in mammals for the first time and could use it to stamp out invasive rodents ravaging seabirds on islands.


Gene-drive technology, so far demonstrated only in insects and yeast, is a powerful way of biasing the inheritance of DNA such that wild animals can be genetically altered as they reproduce, including to cause a population crash.


Now two scientific teams—one in Australia and one in Texas—say they’ve genetically engineered the house mouse, Mus musculus, so that its genome also harbors genetic surprises that could be unleashed on wild populations. The modified rodents were born in the last two months and the results are still preliminary.


The effort to establish gene drives in mammals is being coördinated by Island Conservation, a hard-charging conservation group based in Santa Cruz, California, whose specialty is bombing small islands with rat poison in order to save endangered seabirds. Its motto is “preventing extinctions.”


But poison doesn’t work to extirpate rodents on larger islands or heavily populated ones. That’s why the group thinks gene drives could be the “transformative technology” that allows it to extend its campaign to thousands more islands it says are infested. “We were looking for something really out of the box,” says Karl Campbell, a program director at the nonprofit, which has plans to spent about $7 million a year to speed the technique toward an initial test on a remote island surrounded by miles of ocean, if authorities allow it.