Thursday, September 24, 2020

Friday Thinking 25 Sept 2020

Friday Thinking is a humble curation of my foraging in the digital environment. Choices are based on my own curiosity and that suggest we are in the midst of a change in the conditions of change - a phase-transition. That tomorrow will be radically unlike yesterday.

Many thanks to those who enjoy this.
In the 21st Century curiosity is what skills the cat -

for life of skillful means .

Jobs are dying - Work is just beginning.

Work that engages our whole self becomes play that works.


The emerging world-of-connected-everything - digital environment - 
computational ecology - 
may still require humans as the consciousness of its own existence. 

To see red - is to know other colors - without the ground of others - there is no figure - differences that make a defference.  

‘There are times, ‘when I catch myself believing there is something which is separate from something else.’

“Be careful what you ‘insta-google-tweet-face’”
Woody Harrelson - Triple 9


Content

Quotes:

How to make friends as an adult

YouTube’s Plot to Silence Conspiracy Theories

The Supreme Court and Normcore

How Mathematical ‘Hocus-Pocus’ Saved Particle Physics

Thoughts into words


Articles:

Older people have become younger: physical and cognitive function have improved meaningfully in 30 years

Playing video games as a child can improve working memory years later: study

Artificial intelligence expert originates new theory for decision-making

Great progress for electronic gadgets of the future

GM Ultium Drives to power new generation of e-vehicles

Bacterial enzyme extracts rare earth elements in environmentally friendly way

4 astonishing signs of coal’s declining economic viability

Airbus Unveils Hydrogen Designs for Zero-Emission Flight

Carbon nanotubes developed for super efficient desalination

Coffee associated with improved survival in metastatic colorectal cancer patients





Friends are a treasure. In an uncertain world, they provide a comforting sense of stability and connection. We laugh together and cry together, sharing our good times and supporting each other through the bad. Yet a defining feature of friendship is that it’s voluntary. We’re not wedded together by law, or through blood, or via monthly payments into our bank accounts. It is a relationship of great freedom, one that we retain only because we want to.

But the downside of all this freedom, this lack of formal commitment, is that friendship often falls by the wayside. Our adult lives can become a monsoon of obligations, from children, to partners, to ailing parents, to work hours that trespass on our free time. A study of young adults’ social networks by researchers at the University of Oxford found that those in a romantic relationship had, on average, two fewer close social ties, including friends. Those with kids had lost out even more. Friendships crumble, not because of any deliberate decision to let them go, but because we have other priorities, ones that aren’t quite as voluntary. The title of the Oxford paper summed up things well: ‘Romance and Reproduction Are Socially Costly’.

How to make friends as an adult





As law professor Tim Wu noted in his book The Master Switch, new media tend to start out in a Wild West, then clean up, put on a suit, and consolidate in a cautious center. Radio, for example, began as a chaos of small operators proud to say anything, then gradually coagulated into a small number of mammoth networks aimed mostly at pleasing the mainstream.

YouTube’s Plot to Silence Conspiracy Theories




This seems to me to identify the major internal weakness of the “normcore” approach to analysis that Levitsky and Ziblatt have become associated with. This approach tends to treat norms as worth respecting in and of themselves, on the argument that such norms are what prevent politics from breaking down entirely. This is not an obviously wrong argument, especially in a polity like the U.S., where a two centuries old constitution has been jury-rigged by norms into something that might, just about, manage a modern polity without sinking.

But the problem is that norms are institutions (more precisely, they are informal institutions that are not supported by formal external punishments but by the expectations of the actors that adhere to them) and institutions do not exist in a vacuum. In game theoretic terms, norm maintenance depends on actors’ expectations about “what is off the equilibrium path.” In more practical language, norm maintenance requires not just that political actors worry about the chaos that will ensue if the norms stop working. It also relies on the fear of punishment – that if one side deviates from the political bargain implicit in the norm, the other side will retaliate, likely by breaking the norm in future situations in ways that are to their own particular advantage.

What this means, pretty straightforwardly, is that norms don’t just rely on the willingness of the relevant actors to adhere to them. They also rely on the willingness of actors to violate them under the right circumstances. If one side violates, then the other side has to be prepared to punish. If one side threatens a violation, then the other side has to threaten in turn, to make it clear that deviating from the norm will be costly. A norm governing relations between two opposing sides, where one side acts strategically (to exploit opportunities) and the other naively (always to support the norm) can’t be sustained.

The Supreme Court and Normcore





You don’t have to analyze individual water molecules to understand the behavior of droplets, or droplets to study a wave. This ability to shift focus across various scales is the essence of renormalization.

How Mathematical ‘Hocus-Pocus’ Saved Particle Physics





As cognitive science increasingly reveals, our thinking doesn’t run on a single track, like a serial computer, but seems to be organised into a variety of facilities, or modes of thought, that loosely communicate with each other. The jagged nature of the interaction might be responsible for the sense of fissure within the mind, reported by many writers and thinkers. Language is just one mode of thought, with its own characteristic parameters and limitations. Though it uniquely affords us with a distanced perspective on our thoughts, it is only an imperfect instrument for capturing them. There are other modes that can present us with aspects of reality and interface more directly with our emotions but are less amenable to explicit reasoning and articulation. Only an uncooperative (and mean-spirited) interlocutor would regard our difficulties in articulation as a sign that we lack anything meaningful to say.

Thoughts into words






This is another signal confirming the 60 is the new 50. 

“This research is unique because there are only a few studies in the world that have compared performance-based maximum measures between people of the same age in different historical times,”

“The results suggest that our understanding of older age is old-fashioned. From an aging researcher’s point of view, more years are added to midlife, and not so much to the utmost end of life. Increased life expectancy provides us with more non-disabled years, but at the same time, the last years of life comes at higher and higher ages, increasing the need for care. Among the ageing population, two simultaneous changes are happening: continuation of healthy years to higher ages and an increased number of very old people who need external care.”

Older people have become younger: physical and cognitive function have improved meaningfully in 30 years

The functional ability of older people is nowadays better when it is compared to that of people at the same age three decades ago. This was observed in a study conducted at the Faculty of Sport and Health Sciences at the University of Jyväskylä, Finland. The study compared the physical and cognitive performance of people nowadays between the ages of 75 and 80 with that of the same-aged people in the 1990s.

Among men and women between the ages of 75 and 80, muscle strength, walking speed, reaction speed, verbal fluency, reasoning and working memory are nowadays significantly better than they were in people at the same age born earlier. In lung function tests, however, differences between cohorts were not observed.

“Higher physical activity and increased body size explained the better walking speed and muscle strength among the later-born cohort,” says doctoral student Kaisa Koivunen, “whereas the most important underlying factor behind the cohort differences in cognitive performance was longer education.”


Here’s a very interesting signal - about the longer term impact of playing video games - I wonder what they could do for the aging boomers.
"People who were avid gamers before adolescence, despite no longer playing, performed better with the working memory tasks, which require mentally holding and manipulating information to get a result,"

Playing video games as a child can improve working memory years later: study

A number of studies have shown how playing video games can lead to structural changes in the brain, including increasing the size of some regions, or to functional changes, such as activating the areas responsible for attention or visual-spatial skills. New research from the Universitat Oberta de Catalunya (UOC) has gone further to show how cognitive changes can take place even years after people stop playing.

This is one of the conclusions from the article published in Frontiers in Human Neuroscience. The study involved 27 people between the ages of 18 and 40 with and without any kind of experience with video gaming.

The results show that people without experience of playing video games as a child did not benefit from improvements in processing and inhibiting irrelevant stimuli. Indeed, they were slower than those who had played games as children, which matched what had been seen in earlier studies.

Likewise, "people who played regularly as children performed better from the outset in processing 3-D objects, although these differences were mitigated after the period of training in video gaming, when both groups showed similar levels," said Palaus.


I think this is lovely - incorporating a ‘belief function’ into a mathematical approach to uncertainty - anyone feeling twinges of cognitive dissonance?

Artificial intelligence expert originates new theory for decision-making

How should people make decisions when the outcomes of their choices are uncertain, and the uncertainty is described by probability theory?

That's the question faced by Prakash Shenoy, the Ronald G. Harper Distinguished Professor of Artificial Intelligence at the University of Kansas School of Business.

His answer can be found in the article "An Interval-Valued Utility Theory for Decision Making with Dempster-Shafer Belief Functions," which appears in the September issue of the International Journal of Approximate Reasoning.

"People assume that you can always attach probabilities to uncertain events," Shenoy said.

"But in real life, you never know what the probabilities are. You don't know if it's 50 percent or 60 percent. This is the essence of the theory of belief functions that Arthur Dempster and Glenn Shafer formulated in the 1970s."

His article (co-written with Thierry Denoeux) generalizes the theory of decision-making from probability to belief functions.
"Probability decision theory is used for making any sort of high-stakes choice. Like should I accept a new job or a marriage proposal? Something high stakes. You wouldn't need it for where to go for lunch," he said.


This may seem a bit arcane - but really is simply grasping exponential increases in computational capabilities for the same costs - The capabilities vs cost of a computing device in 1960 vs the the same cost can deliver now in 2020 - with a changing paradigm the material manifestation of a transistor - could be a single molecule in 2060?Sooner? - what will devices be? 

We rarely think about the technology that lies behind turning on a light bulb or our use of electrical appliances. The control of charged particles on a minute scale is simply part of everyday life.

But on a much smaller nanoscale, scientists are now routinely able to manipulate the flow of electrons. This opens up possibilities for even smaller components in computers and mobile phones that use barely any electricity.

Great progress for electronic gadgets of the future

Researchers at the Norwegian University of Science and Technology (NTNU) have found a completely new method to check the electronic properties of oxide materials. This opens the door to even tinier components and perhaps more sustainable electronics.

"We found a completely new way to control the conductivity of materials at the nanoscale," says Professor Dennis Meier at NTNU's Department of Materials Science and Engineering.

One of the best aspects of the new method is that it does not interfere with other properties of the material, like previous methods did. This makes it possible to combine different functions in the same material, which is an important advance for nanoscale technology.

A new article in the journal Nature Materials addresses the findings. The article has attracted international attention even before being printed.


In my hippie youth when I owned a chevy van - it was an old one - but I was handy enough with it - that once during midwinter in Ottawa - I had to stop on the side of the street - lift the engine hood - take of the carburetor and take apart enough to clean - re-install - start the engine and continue - I wonder if the new electric engines promise that level of use-interaction?

The 30 sec video is worth the view

GM Ultium Drives to power new generation of e-vehicles

General Motors on Wednesday announced plans for the production of a family of electric motors and drive units for its next generation of electric cars and trucks.

It will design and manufacture five interchangeable electric powertrains and three electric motors under the name Ultium Drive. The electric drive systems will be used across a spectrum of vehicles, from passenger cars to pickup trucks to high performance autos.

As it transitions to a complete electric lineup, GM vehicles will have better integration between the engine and electrical system and the car's other components and achieve greater efficiencies with Ultium Drive.

The new electric drive systems, also referred to as e-drives, combine gear, motor and power electronics into a single system that will more efficiently convert energy to drive the vehicle. By building the power electronics into the drive assemblies, greater power is attained in roughly half the space. And the system is lighter.


An interesting signal of the emergence of the domestication of bacteria - for manufacturing.

Bacterial enzyme extracts rare earth elements in environmentally friendly way

Rare earth elements are vital for many modern technologies. Chemists at LMU have now shown that a cofactor found in a bacterial enzyme can selectively extract some of these metals from mixtures in an environmentally benign fashion.

Rare earth elements (REEs) are an indispensable ingredient of the electronic devices that are now an integral part of our daily lives. They are employed in computers, smartphones, electric motors and many other key technologies as components of magnets and batteries, and also serve as powerful chemical catalysts. REEs comprise 17 elements—scandium, yttrium, lanthanum and the 14 lanthanides that follow lanthanum in the Periodic Table. In nature, they occur as mixtures and are often found in association with the radioactive elements uranium and thorium. All REEs exhibit very similar chemical properties, which makes separating them from each other a difficult, energy-intensive and environmentally problematic task. Now a team led by LMU chemist Professor Lena Daumann has shown that an enzyme cofactor called pyrroloquinoline quinone (PQQ) found in certain species of bacteria selectively binds to specific REEs and can be used to separate them from mixtures.

That REEs also play essential roles in the biosphere was discovered less than 10 years ago, when it was shown that certain types of bacteria can selectively take up lanthanides from the environment, which are then incorporated into enzymes for use as metabolic catalysts. 


This is definitely a strong signal - time to listen carefully.

4 astonishing signs of coal’s declining economic viability

Coal is now a loser around the world.
in the US and across the world, coal power is dying. By 2030, it will be uneconomic to run existing coal plants. That means all the dozens of coal plants on the drawing board today are doomed to become stranded assets. 

1. It is already cheaper to build new renewables than to build new coal plants, in all major markets.
2. Over half the existing global coal fleet is more expensive to run than building new renewables.
3. By 2030, it will be cheaper to build new renewables than to run existing coal — everywhere.
4. Investors stand to lose over $600 billion on doomed coal plants.


This is another small signal in the transformation of energy and transportation.

Airbus Unveils Hydrogen Designs for Zero-Emission Flight

European planemaker Airbus SE unveiled three designs it’s studying to build hydrogen-powered aircraft as it races to bring a zero-carbon passenger plane into service by 2035.

The approaches include a turbofan jet with capacity for as many as 200 passengers -- similar to its A321neo narrow-body -- that can fly more than 2,000 nautical miles, according to a statement Monday. It would be powered by a modified gas-turbine engine running on hydrogen.

The manufacturer also showed a design for a propeller plane which would seat about 100 passengers for smaller distances, and a flying-wing concept with 200 seats.

The company is under pressure from the French and German governments, its biggest shareholders, to speed development of new aircraft after aiding the planemaker during the coronavirus crisis. Together, the two countries have committed some 2.5 billion euros ($2.9 billion) toward cleaner propulsion.


Another small signal of the progress to make drinkable water more widely available cheaply.

Carbon nanotubes developed for super efficient desalination

Membrane separations have become critical to human existence, with no better example than water purification. As water scarcity becomes more common and communities start running out of cheap available water, they need to supplement their supplies with desalinated water from seawater and brackish water sources.

Lawrence Livermore National Laboratory (LLNL) researchers have created carbon nanotube (CNT) pores that are so efficient at removing salt from water that they are comparable to commercial desalination membranes. These tiny pores are just 0.8 nanometers (nm) in diameter. In comparison, a human hair is 60,000 nm across. The research appears on the cover of the Sept. 18 issue of the journal Science Advances.

Biological water channels, also known as aquaporins, provide a blueprint for the structures that could offer increased performance. They have an extremely narrow inner pore that squeezes water down to a single-file configuration that enables extremely high water permeability, with transport rates exceeding 1 billion water molecules per second through each pore.


So just because I love coffee - to the point I roast my own beans. 

Coffee associated with improved survival in metastatic colorectal cancer patients

The investigators found that in 1,171 patients treated for metastatic colorectal cancer, those who reported drinking two to three cups of coffee a day were likely to live longer overall, and had a longer time before their disease worsened, than those who didn't drink coffee. Participants who drank larger amounts of coffee—more than four cups a day—had an even greater benefit in these measures. The benefits held for both caffeinated and decaffeinated coffee.

The findings enabled investigators to establish an association, but not a cause-and-effect relationship, between coffee drinking and reduced risk of cancer progression and death among study participants. As a result, the study doesn't provide sufficient grounds for recommending, at this point, that people with advanced or metastatic colorectal cancer start drinking coffee on a daily basis or increase their consumption of the drink, researchers say.

Thursday, September 17, 2020

Friday Thinking 18 Sept 2020

 Friday Thinking is a humble curation of my foraging in the digital environment. Choices are based on my own curiosity and that suggest we are in the midst of a change in the conditions of change - a phase-transition. That tomorrow will be radically unlike yesterday.

Many thanks to those who enjoy this.
In the 21st Century curiosity is what skills the cat -

for life of skillful means .

Jobs are dying - Work is just beginning.

Work that engages our whole self becomes play that works.


The emerging world-of-connected-everything - digital environment - 
computational ecology - 
may still require humans as the consciousness of its own existence. 

To see red - is to know other colors - without the ground of others - there is no figure - differences that make a defference.  

‘There are times, ‘when I catch myself believing there is something which is separate from something else.’

“Be careful what you ‘insta-google-tweet-face’”
Woody Harrelson - Triple 9




many threads all finally converge in the counterintuitive thesis of The Force of Nonviolence: that nonviolence is not the antithesis of self-defense but rather is self-defense. Butler raises this provocative claim as a rejoinder to left discourses of violent resistance. Counterviolence, so the argument goes, is required to defend the oppressed from the systemic violence they suffer. The Force of Nonviolence responds not by challenging the tactical wisdom of these arguments, but instead by questioning the very idea of self at their core. Once the self is seen in relational terms, sustained through bonds that exceed sovereign control, the goal of defending the self is turned inside out, since it must now encompass protecting and expanding the social infrastructure through which lives can be more equitably lived. Acts of violence that put these bonds at risk are not simply immoral, they are self-defeating. “Violence against the other is, in this sense,” Butler writes, “violence against oneself, something that becomes clear when we recognize that violence assaults the living interdependency that is, or should be, our social world.” Nonviolence is the practice of tending to this web of “living interdependency,” or as she calls it elsewhere in the book, life itself.

Bonds of interdependence are the sources of both life and aggression. They endow us with worth and care, yet they also continually remind the ego of the limits of its power and its dependency on others.

Coupling confrontation and care means to do more than simply “expose” unseen violence, as Butler repeatedly suggest; it means to meet people where they are and help educate their judgments to see some issue—and their own relation to it—anew. This is interdependence as something to be made not found, a political project of constructing a new public around an issue rather than returning people to some existential facts of the human condition.

Inventing Nonviolence




Jaspers is one of the very few existentialist thinkers who did not seek to master, tame or conquer the unknowable and finite condition of human life. Instead, he tried to cultivate a relationship to this essential quality of life and engage it on its own terms. He repeatedly insisted that ‘I do not accomplish my freedom. I did not make myself. I do not exist by my own means.’ Rather, I depend on the freedom of others and the complex makings of a fragile world. Only because our lives are contingent and vulnerable can we experience love, freedom and purpose as something meaningful. The attempt to prove love or catch the ephemeral presence of beauty would likely take away the experience. 

What we come to understand in moments of happiness, loss and tragedy is that we cannot possess meaning, we cannot own who we authentically are or determine our identity. Uncertainty was not something to overcome for Jaspers. He rather considered it the ground of ideas such as freedom, truth and justice that can be defined only negatively, through what they are not, or not yet.

But how should it be possible to think this relational truth and uncertainty together? Jaspers believed that we might not be able to come to an agreement about who we are and what we want to be, but we can agree on what we don’t know and how we’d like to act toward this nonknowledge. There is containment in the expression of uncertainty. It generates a humble, but highly resistant and communicative approach to the world. ‘All thoughts,’ Jaspers therefore concluded, ‘could be judged by this touchstone question, do they aid or hinder communication.’ 

To Karl Jaspers, uncertainty is not to be overcome but understood






This is an interesting and testable insight - AI-ssistants for everyone - the question is who is the AI-ssistant assisting
Experiment if you’re game: start a social media account and follow people and places that have the opposite of your ideology. Watch what the algorithm feeds that account. Compare to yours. We are not that different. We are being pitted against each other. IMOIMOIMO


This is a great 14min video of Kevin Kelly giving 68 great tips on his 68th birthday

68 Bits of Unsolicited Advice

It’s my birthday. I’m 68. I feel like pulling up a rocking chair and dispensing advice to the young ‘uns. Here are 68 pithy bits of unsolicited advice which I offer as my birthday present to all of you.


I think we can expect to see this as a mass produced product soon - even if Covid-19 is controlled via a vaccine - there are all manner of uses now and in the future.

Researchers develop anti-bacterial graphene face masks

Face masks have become an important tool in fighting against the COVID-19 pandemic. However, improper use or disposal of masks may lead to "secondary transmission". A research team from City University of Hong Kong (CityU) has successfully produced graphene masks with an anti-bacterial efficiency of 80%, which can be enhanced to almost 100% with exposure to sunlight for around 10 minutes. Initial tests also showed very promising results in the deactivation of two species of coronaviruses. The graphene masks are easily produced at low cost, and can help to resolve the problems of sourcing raw materials and disposing of non-biodegradable masks.

The research is conducted by Dr. Ye Ruquan, Assistant Professor from CityU's Department of Chemistry, in collaboration with other researchers. The findings were published in the scientific journal ACS Nano, titled "Self-Reporting and Photothermally Enhanced Rapid Bacterial Killing on a Laser-Induced Graphene Mask".


This is a long - but very interesting history of what seems to be a ubiquitous aspect of our reality - a metaphor for understanding culture, language and more. 

Introduction: The Software Age

1953 - “Software” was merely a prank
1963 - “Software” became an industry
1973 - “The Software Age” has begun!
In October, 1953, I coined the word 'software.'
The notion of software as a separate thing from hardware took years to assert itself. Sure, the computer (popularly referred to as a "giant brain" in the early fifties) was unable to do anything but consume electrical power until a "programmer" came along to "program" it, and the consequent "routines" resided in the computer's "memory" thereafter. One did not, in the beginning, take a program written for one computer and put it into another.  A half-century later, most people will find that hard to imagine.

As originally conceived, the word 'software' was merely an obvious way to distinguish a program from the computer itself. A program comprised sequences of written -- changeable -- instructions each endowed with the power to command the behavior of the permanently crafted machinery -- the "hardware."

For the origin of the word 'software,' most dictionaries give an unknown source and 1960 as the date, but [expletive deleted] I was there! That's the only exclamation point I intend to use in this introduction.


This is a fascinating signal - of the power of easily producing many versions - can illustrate the flaws of one version - this is especially important as the digital environment can enable a form of transparent accessible comparisons of policy.
The party that controls the maps can grab power through packing or cracking. In packing, politicians cram voters from the opposing party into just a few districts, securing the remaining districts for their own party. The blue ruling party created one all-red district, and three majority blue districts. In cracking, politicians spread voters from the opposing party across districts, blocking them from gaining a majority.

How next-gen computer generated maps detect partisan gerrymandering

Researchers are ready to expose hidden biases when redistricting begins in 2021
In October 2019, a state court determined that North Carolina’s congressional districts had been severely gerrymandered and struck down the state’s map. The court’s ruling was informed, in part, by tens of thousands of alternative maps demonstrating that the district boundaries had very likely been manipulated for political gain, the very definition of gerrymandering.

Researchers had generated a slew of alternative, computer-generated maps designed to help identify potential patterns of bias. The approach is increasingly used, alongside other tests, to ferret out alleged gerrymandering. District manipulations can be so subtle that they’re undetectable just by looking at them. “The eyeball test is no good,” says Jonathan Katz, a political scientist and statistician at Caltech.

U.S. states redraw their district lines every 10 years to adjust for changing demographics picked up by the national census. The last round a decade ago raised eyebrows, most notably for districts drawn in Michigan, North Carolina and Pennsylvania.

“The post-2010 round of redistricting is widely viewed as a time of extreme, even egregious, partisan gerrymandering,” retired political scientist Richard Engstrom wrote in the January 2020 Social Science Quarterly.


This is a very interesting weak signal - although the discussion is focused on the belief in God - if we replace the concept of ‘god’ with ‘conspiracy theory’ this could contribute to an understanding of how people with capacity to reason - fall prey to - well conspiracies.

"This is not a study about whether God exists, this is a study about why and how brains come to believe in gods. Our hypothesis is that people whose brains are good at subconsciously discerning patterns in their environment may ascribe those patterns to the hand of a higher power,"

"A brain that is more predisposed to implicit pattern learning may be more inclined to believe in a god no matter where in the world that brain happens to find itself, or in which religious context,"

Study suggests unconscious learning underlies belief in God

Individuals who can unconsciously predict complex patterns, an ability called implicit pattern learning, are likely to hold stronger beliefs that there is a god who creates patterns of events in the universe, according to neuroscientists at Georgetown University.

Their research, reported in the journal, Nature Communications, is the first to use implicit pattern learning to investigate religious belief. The study spanned two very different cultural and religious groups, one in the U.S. and one in Afghanistan.

The goal was to test whether implicit pattern learning is a basis of belief and, if so, whether that connection holds across different faiths and cultures. The researchers indeed found that implicit pattern learning appears to offer a key to understanding a variety of religions.


This is an interesting signal about emerging depths of knowledge and the domestication of DNA - and relationships to behavioral consequences.

Discoverer of neural circuits for parenting wins US$3 million Breakthrough Prize

Biologist Catherine Dulac netted one of four big life-sciences awards. Also announced were one for mathematics and two for physics.
Discovering the “on-and-off switch” for good parenting in both male and female mouse brains has earned Catherine Dulac, a molecular biologist at Harvard University, in Cambridge, Massachusetts, one of this year’s US$3-million Breakthrough prizes — the most lucrative awards in science and mathematics. Three other major prizes in biology, plus two in physics and one in mathematics, were also announced on 10 September, together with a number of smaller prizes.

“Catherine Dulac has done amazing work that has really transformed the field,” says biologist Lauren O’Connell, at Stanford University, California. Dulac’s team provided the first evidence that male and female mouse brains have the same neural circuitry associated with parenting, which is just triggered differently in each sex1. “It went against the dogma that for decades said that male and female brains are organized differently,” says O’Connell.

To elucidate the neural mechanisms at play, Dulac identified a protein called galanin that is expressed by neurons involved in parenting. Killing the neurons in females stopped them parenting, while activating them in virgin males made them maternal. “It’s like an on-and-off switch for parenting,” says Dulac. “It’s extraordinary.” Her team then used the galanin marker to track the specific circuitry associated with the motivational, hormonal and behavioural changes needed for nurturing.


An interesting signal about the future of medicine - the domestication of our microbiomes.

Live bacteria spray is showing promise in treating childhood eczema

Here’s a shorthand way to think of my research: Using bugs as drugs may one day bring hope to soaps.
Patients with atopic dermatitis, more commonly known as eczema, suffer from dry, itchy skin and rashes, and have a higher risk of developing hay fever, asthma and food allergies. The cause of eczema is still unknown, but studies completed by my team and others continue to suggest that manipulating the skin microbiome – the community of all the bacteria and other microorganisms living on the surface of the skin – may offer therapeutic benefits to patients.

We hypothesized that if we directly sprayed live bacteria named Roseomonas mucosa - a naturally occurring skin microbe - on the skin of patients with eczema, those healthy bacteria might make for healthy skin.


This is still a weak signal - but imagine a swarm of biobots delivering medicine and/or being the medical device for all manner of ‘taking out the garbage’ and adding the nutrients and more in our bodies and environment and agriculturing activities (remembering that every single technology can be weaponized).

Scientists create a robot made entirely of living cells

'Xenobots' could be used to clean up microplastics or deliver medication in the body
Scientists have unveiled the first ever "living robot," an organism made up of living cells, which can move around, carry payloads, and even heal itself.

"All of the computational people on the project, myself included, were flabbergasted," said Joshua Bongard, a computer scientist at the University of Vermont.  

"We didn't realize that this was possible."

Teams from the University of Vermont and Tufts University worked together to build what they're calling "xenobots," which are about the size of a grain of salt and are made up of the heart and skin cells from frogs.

"The particular frog that we borrowed these cells from is known as Xenopus laevis," Bongard told Quirks & Quarks host Bob McDonald.

"But Xeno is also in Greek stands for alien, or unknown, or different, or new, and we think both interpretations apply to this new kind of technology."


Learning to control our bio-nano-computational bots and fabrication technologies - is vital.

Flipping light on-off turns bacteria into chemical factories

Researchers at Princeton University have created a new and improved way to more precisely control genetically engineered bacteria: by simply switching the lights on and off. Working in E. coli, the workhorse organism for scientists to engineer metabolism, researchers developed a system for controlling one of the key genetic circuits needed to turn bacteria into chemical factories that produce valuable compounds such as the biofuel isobutanol.

"All you need is illumination," said José Avalos, an assistant professor of chemical and biological engineering at Princeton University and at the Andlinger Center for Energy and the Environment", and senior author of the findings, published in Nature Chemical Biology. "There are lots of potential benefits, one of them being the ability to easily tune and reverse the induction signal."

The new work builds on Avalos and his colleagues' previous work, described in Nature in 2018, in which they engineered of yeast to produce chemicals in the presence or absence of light. E. coli, however, is even more widely used by scientists and engineers than yeast.


This is another good signal of our exploration into the inner space of our own ecology - the digital environment is exponentially creating massive data through ever more sensors - in ever more places. Finding out about who we really are.

Sampling the gut microbiome with an ingestible pill

Gut microbes affect human health, but there is still much to learn, in part because they're not easy to collect. But researchers now report in ACS Nano that they have developed an ingestible capsule that in rat studies captured bacteria and other biological samples while passing through the gastrointestinal (GI) tract.

Currently, researchers obtain gut microbes by collecting stool samples or using techniques such as colonoscopy or endoscopy. However, stool samples can't capture all the microorganisms in the upper GI tract, and they can't keep microbes from different parts of the tract separate. Colonoscopy and endoscopy are invasive procedures, which deters some patients. Sarvesh Kumar Srivastava and colleagues wanted to avoid these drawbacks by designing a device that could be swallowed and then eliminated.

The researchers developed a self-polymerizing reaction system of poly(ethylene glycol) diacrylate monomer, iron chloride and ascorbic acid—all loaded into tiny hollow cylinders. The cylindrical microdevices were packaged in miniature gelatin capsules, which were coated with a protective layer to prevent digestion in the stomach's acidic environment. After they were fed to rats, the capsules remained protected in the stomach but disintegrated in the small intestine's more-neutral pH, releasing the microdevices. Exposure to intestinal fluid caused the cylinders' chemical cargo to polymerize, forming a hydrogel that trapped microbes and protein biomarkers in its surroundings, much like an instant snapshot of the intestine.