Thursday, January 2, 2020

Friday Thinking 3 Jan 2020

Friday Thinking is a humble curation of my foraging in the digital environment. My purpose is to pick interesting pieces, based on my own curiosity (and the curiosity of the many interesting people I follow), about developments in some key domains (work, organization, social-economy, intelligence, domestication of DNA, energy, etc.)  that suggest we are in the midst of a change in the conditions of change - a phase-transition. That tomorrow will be radically unlike yesterday.

Many thanks to those who enjoy this.

In the 21st Century curiosity will SKILL the cat.

Jobs are dying - Work is just beginning.
Work that engages our whole self becomes play that works.
Techne = Knowledge-as-Know-How :: Technology = Embodied Know-How  
In the 21st century - the planet is the little school house in the galaxy.
Citizenship is the battlefield of the 21st  Century

“Be careful what you ‘insta-google-tweet-face’”
Woody Harrelson - Triple 9


Content
Quotes:

Articles:



Adam Smith offered advice for how societies should handle the rich: he calls on legislators not to put the interests of wealthy monopolists ahead of the public welfare. Whenever new government legislation is proposed by businessmen, Smith suggests the government should treat the new proposal with “not only with the most scrupulous, but with the most suspicious attention”.

The handouts to the rich that he complains about in Wealth of Nations have never entirely disappeared. Instead, a language of “free trade” has obscured the government’s role in favouring the wealthy. Just look at the past 30 years, a time of ever-growing subsidies to pharmaceutical executives who gouge consumers with unacceptably high drug prices; tax gifts to tech corporations that lobby to erode worker and consumer protections; the ever-replenishing “money-tree” of quantitative easing programmes that rain on the rich while the poor work ever-longer hours.

Smith did talk about the invisible hand. But he also wrote about the “invisible chains” that structure people’s lives. He and his revolutionary friends understood that wealth inequality could become a type of invisible cage. He taught his readers a simple lesson: keep the power of the rich in check.

Capitalism’s Case for Abolishing Billionaires





“Thirty years ago, we used to ask: Can a computer simulate all processes of logic? The answer was yes, but the question was surely wrong. We should have asked: Can logic simulate all sequences of cause and effect? And the answer would have been no.”

What is the pattern that connects the crab to the lobster and the primrose to the orchid, and all of them to me, and me to you?

― Gregory Bateson, Mind and Nature




 ‘There are times, … when I catch myself believing there is something which is separate from something else.’

Impossible choices





There’s a metaphor that’s only been available to us in the past 30 or 40 years, and that’s the desktop interface. Suppose there’s a blue rectangular icon on the lower right corner of your computer’s desktop — does that mean that the file itself is blue and rectangular and lives in the lower right corner of your computer? Of course not. But those are the only things that can be asserted about anything on the desktop — it has color, position and shape. Those are the only categories available to you, and yet none of them are true about the file itself or anything in the computer. They couldn’t possibly be true. That’s an interesting thing. You could not form a true description of the innards of the computer if your entire view of reality was confined to the desktop. And yet the desktop is useful. That blue rectangular icon guides my behavior, and it hides a complex reality that I don’t need to know. That’s the key idea. Evolution has shaped us with perceptions that allow us to survive. They guide adaptive behaviors. But part of that involves hiding from us the stuff we don’t need to know. And that’s pretty much all of reality, whatever reality might be. If you had to spend all that time figuring it out, the tiger would eat you.

The Evolutionary Argument Against Reality





This is a signal whose time is nigh. The evolution of the atomistic, isolated, selfish notion of self toward self and inevitable social and entangled. I encourage everyone to sign on. This is inaugurated by a Canadian Henry Mintzberg.

The Declaration of Our Interdependence For 2020 Vision

For two centuries, the American Declaration of Independence served as the model to grow democracy. Now our world has reached the limits of growth driven by the pursuit of individual rights at the expense of shared responsibilities. Faced with the threats of warming, weapons, waste, and the lopsided distribution of wealth, we must declare our interdependence.

We hold these truths to be self-evident, that all people are created dependent—on each other, our earth, and its climate—endowed with the inalienable responsibility to maintain justice, liberty, and affiliation for all. Thus our societies must sustain balance across public sector governments that are respected, private sector businesses that are responsible, and plural sector communities that are robust. Some societies retain this balance; others have lost it; many never had it. We propose the following resolutions to guide the rebalancing of society: ….


Here’s another signal of the emerging sense of entanglement.
Unlike the Enlightenment, where progress was analytic and came from taking things apart, progress in the Age of Entanglement is synthetic and comes from putting things together. Instead of classifying organisms, we construct them. Instead of discovering new worlds, we create them. 

The Enlightenment is Dead, Long Live the Entanglement

We can no longer see ourselves as separate from the natural world or our technology, but as a part of them, integrated, codependent, and entangled.
We humans are changing. We have become so intertwined with what we have created that we are no longer separate from it. We have outgrown the distinction between the natural and the artificial. We are what we make. We are our thoughts, whether they are created by our neurons, by our electronically augmented minds, by our technologically mediated social interactions, or by our machines themselves. We are our bodies, whether they are born in womb or test tube, our genes inherited or designed, organs augmented, repaired, transplanted, or manufactured. Our prosthetic enhancements are as simple as contact lenses and tattoos and as complex as robotic limbs and search engines. They are both functional and aesthetic. We are our perceptions, whether they are through our eyes and ears or our sensory-fused hyper-spectral sensors, processed as much by computers as by our own cortex. We are our institutions, cooperating super-organisms, entangled amalgams of people and machines with super-human intelligence, processing, sensing, deciding, acting. Our home planet is inhabited by both engineered organisms and evolved machines. Our very atmosphere is the emergent creation of forests, farms and factories. Our networks of commerce, power and communications are becoming as richly interconnected as ecologies and nervous systems. Empowered by the tools of the Enlightenment, connected by networked flows of freight and fuel and finance, by information and ideas, we are becoming something new. We are at the dawn of the Age of Entanglement.


This is a great 29 min video summarizing key features of the emerging digital environment and its ecology of platforms. Why we have to accelerate the scaling of learning.

SU Global Summit 2019 | Platforms & Ecosystems | John Hagel

John Hagel, Co-Chairman of Deloitte's Center for the Edge, shows how platform thinking and ecosystem development can lead to better strategy and execution.


This  is an excellent 26 min video offering some economic policy considerations based on Modern Monetary Theory - the next emerging economic paradigm for meeting the challenges of climate change, economic inequality and more.

Warren Mosler: What Modern Monetary Theory Tells Us About Economic Policy

This episode features Warren Mosler, president of the financial services firm Valance Company and one of the founders of Modern Monetary Theory (MMT), speaking about what MMT tells us about economic policy. He explains not only what policy makers can do but also what they should do in the current economic environment. How can MMT help get the economy back on track? Watch the interview to find out!


This is an important signal - one wonders if it can improve a nation’s sovereignty over the creation of money or constrain it in an artificial scarcity sort of way.

Say Goodbye to Banking as We Know It

China is poised to launch the first national digital currency. There will be no counting the disruption.  
So is China readying its own Bitcoin? Banish the thought.

It’s far bigger than that. Yes, just like any other cryptocurrency — or for that matter, cigarettes in prisoners-of-war camps — the upcoming digital yuan will be “tokenized” money. But the similarity ends there. The crypto yuan, which may be on offer as soon as 2020, will be fully backed by the central bank of the world’s second-largest economy, drawing its value from the Chinese state’s ability to impose taxes in perpetuity. Other national authorities are bound to embrace this powerful idea.    

Little is known about the digital yuan except that it’s been in the works for five years and Beijing is nearly ready to roll. The consensus is that the token will be a private blockchain, a peer-to-peer network for sharing information and validating transactions, with the People’s Bank of China in control of who gets to participate. To begin with, the currency will be supplied via the banking system and replace some part of physical cash. That won’t be hard, given the ubiquitous presence of Chinese QR code-based digital wallets such as Alipay and WeChat Pay.


This is a signal of changing paradigms around drugs, plant medicines and consciousness development and therapies.
Within 10 years we are likely to have multiple psychedelic-assisted therapies approved in the US, Europe, and in many countries around the world for the treatment of various mental health conditions. As new success stories from treatment with psychedelic therapy continue to emerge, and new scientific evidence continues to be collected from ongoing clinical trials and neuropsychopharmacology research, many more patients will be asking for these treatments. We’ll see multiple forms of treatment centers emerge, including psychiatric hospitals as well as privately owned clinics and independent practitioners. Psychedelic therapy is on track to be the next major breakthrough in mental health care.

The future of psychedelic science: What the next decade holds

The last decade has been inarguably incredible for the field of psychedelic science. The term renaissance is hyperbolically thrown around a lot these days but in this context it is perfectly apt. Moving from the fringes of the research world and shaking off years of baggage from illicit recreational circles, scientists have made startling progress in legitimizing the medical potential of these drugs.

With both MDMA and psilocybin on the precipice of approvals as mainstream medicines, and several leading universities opening dedicated psychedelic research facilities, the story of the last 10 years has been one of profound breakthroughs. So, as we stand on the precipice of a new decade, it's worth pausing for a moment and looking forward to investigate what the 2020s may hold in this rapidly accelerating field.

New Atlas spoke to several leading psychedelic researchers to get their thoughts on three big future-forward questions. Where will psychedelic science be in 2030, what is the biggest hurdle psychedelic researchers will face in the 2020s, and what is the most interesting psychedelic research topic that has yet to be fully explored?


This is a fascinating signal regarding human perception that could contribute to understanding some phenomena such as dosing and other sorts of ‘psychic’ experience.
Previous tests of human magnetoreception have yielded inconclusive results. This new evidence “is one step forward for the magnetoreception field and probably a big step for the human magnetic sense, I do hope we can see replications and further investigations in the near future.”

People can sense Earth’s magnetic field, brain waves suggest

A new study hints that humans have magnetoreception abilities, similar to some other animals
A new analysis of people’s brain waves when surrounded by different magnetic fields suggests that people have a “sixth sense” for magnetism.

Birds, fish and some other creatures can sense Earth’s magnetic field and use it for navigation. Scientists have long wondered whether humans, too, boast this kind of magnetoreception. Now, by exposing people to an Earth-strength magnetic field pointed in different directions in the lab, researchers from the United States and Japan have discovered distinct brain wave patterns that occur in response to rotating the field in a certain way.

These findings, reported in a study published online in eNeuro, offer evidence that people do subconsciously respond to Earth’s magnetic field — although it’s not yet clear exactly why or how our brains use this information.


This is still a weak but very important signal of the future of computation and more.

Information teleported between two computer chips for the first time

Scientists at the University of Bristol and the Technical University of Denmark have achieved quantum teleportation between two computer chips for the first time. The team managed to send information from one chip to another instantly without them being physically or electronically connected, in a feat that opens the door for quantum computers and quantum internet.

This kind of teleportation is made possible by a phenomenon called quantum entanglement, where two particles become so entwined with each other that they can “communicate” over long distances. Changing the properties of one particle will cause the other to instantly change too, no matter how much space separates the two of them. In essence, information is being teleported between them.

Hypothetically, there’s no limit to the distance over which quantum teleportation can operate – and that raises some strange implications that puzzled even Einstein himself. Our current understanding of physics says that nothing can travel faster than the speed of light, and yet, with quantum teleportation, information appears to break that speed limit. Einstein dubbed it “spooky action at a distance.”

Harnessing this phenomenon could clearly be beneficial, and the new study helps bring that closer to reality. The team generated pairs of entangled photons on the chips, and then made a quantum measurement of one. This observation changes the state of the photon, and those changes are then instantly applied to the partner photon in the other chip.


Another signal of the transformation of energy geopolitics.

South Australia’s clean-energy shift brings lowest power prices on national grid, audit finds

For first time, state has cheaper wholesale power than rest of country for consecutive months
The shift to more than 50% clean energy in South Australia led to the lowest average wholesale power prices in the national electricity grid over the past two months, an audit has found.

According to the national energy emissions audit published by the Australia Institute, South Australia has had lower monthly wholesale electricity prices than Victoria since January, than New South Wales since August and than Queensland and Tasmania for the past two months.

It is the first time the state has had cheaper wholesale power than all other states for consecutive months. It coincided with the percentage of electricity from wind and solar energy in the state reaching nearly 65% in November.


Another weakish signal but one that may be important in accelerating the transformation of energy geopolitics. It also signals the increasing capabilities of the use of AI in science discovery.

AI enables design of spray-on coating that can generate solar energy

A new system enables optimization of perovskite materials for the production of technology that could make solar energy ubiquitous.
Solar energy is increasingly becoming a source of renewable energy throughout the world. Now researchers have found a way that could make generating energy from the sun even more ubiquitous by creating a spray coating that can be used on bridges, houses, or even skyscrapers so they can be energy self-sufficient.

A team from the University of Central Florida used artificial intelligence (AI), or machine learning, to optimize the materials used to make perovskite solar cells, or PSCs. The organic-inorganic halide perovskites material used in PSC converts photovoltaic power into consumable energy.

Perovskite cells in general have long been viewed as the future of solar cells because the material has key advantages over the silicon used to develop this technology today, including higher efficiency and less cost in cell production.

Another benefit of perovskite solar cells is that they can be produced not just in a solid-state form for typical solar panels, but also in a liquid state, which expands the flexibility of how solar-energy-generation technology can be delivered, researchers said. This could ultimately pave the way for any object or structure to generate its own electricity from the sun, which could revolutionize how people use energy.

[the] team reviewed more than 2,000 peer-reviewed publications about perovskites and collected more than 300 data points that they then transferred into a machine-learning system they created, he said. The system analyzed the information and predicated which recipe for perovskites would optimize the material for solar-energy generation.

The results of the study show that AI can be used to craft perovskite materials for the creation of highly efficient technology to make this type of renewable energy more prevalent, Thomas said. “This can be a guide to design new materials as evidenced by our experimental demonstration,” he said. Researchers published a paper on their work in the journal Advanced Energy Materials.


This is another strong signal of the rise of AI as the next cognitive prosthetic enhancing human capacity.

Google just beat humans at spotting breast cancer — but it won’t replace them

A new study reveals Google AI is often better at detecting breast cancer than actual doctors
Google is developing artificial intelligence to help doctors identify breast cancer, according to a research paper published in Nature today. The model, which scans X-ray images known as mammograms, reduces the number of false negatives by 9.4 percent—a hopeful leap forward for a test that currently misses 20 percent of breast cancers, as reported by The New York Times.

Today, breast cancer is the second leading cause of death in women, beat out only by lung cancer in its deadliness and overall prevalence. Early detection is the best defense most people have in identifying and treating the disease. Yet while mammograms are the most common detection tool, they miss a large number of cases. “Mammograms are very effective but there’s still a significant problem with false negatives and false positives,” Shravya Shetty, a researcher at Google who co-authored the paper, tells The Verge.

In the study, which Google funded, researchers used anonymized mammograms from more than 25,000 women in the UK and 3,000 women in the US. “We tried to follow the same principles radiologists might follow,” Shetty says. According to Google’s blog post, the team first trained AI to scan X-ray images, then looked for signs of breast cancer by identifying changes in the breasts of the 28,000 women. They then checked the computer’s guesses against the women's’ actual medical outcomes.

Ultimately, they were able to reduce false negatives by 9.4 percent and cut down false positives by 5.7 percent for women in the US. In the UK, where two radiologists typically double-check the results, the model cut down false negatives by 2.7 percent and reduced false positives by 1.2 percent. “The model performs better than an individual radiologist in both the UK and the US,”


This is a great signal of the possibilities for the future of food - not just urban and vertical farms - but a new form of commons.

The rise of urban food forests

Cities like Atlanta and Philadelphia are recognizing a park can be more than just a green space when visitors are allowed to pick fruits, vegetables and nuts.
A walk through an Atlanta park will soon include the option of picking berries, plucking apples from trees or gathering herbs from surrounding plants — all for free. 
The Food Forest at Browns Mill, which has been years in the making, surged ahead in May when the Atlanta City Council unanimously approved an ordinance to use grant money secured from the U.S. Forest Service to purchase a 7.1-acre plot of land from The Conservation Fund for a food forest.

The land was a working farm for decades but sold for redevelopment in 2006; the development plan was abandoned when the recession hit and the land sat vacant until The Conservation Fund purchased it in 2016.

The park will serve as a community green space complete with trails and a large-scale edible garden. Atlanta's Department of Parks and Recreation will oversee the property while nonprofit Trees Atlanta maintains it. Volunteers already have pitched in for site restoration and construction — including creek and pecan orchard restoration — in addition to planting hundreds of food-bearing trees and plants.

The city conducted extensive community outreach and assessments to identify available land for this project. Some of the suggested properties no longer were suitable for other developments due to issues like drainage, but they could work as a food forest. Targeting these properties carries the ancillary benefit of eliminating blight and improving quality of life for citizens within the neighborhood.

Thursday, December 26, 2019

Friday Thinking 27 Dec 2019

Friday Thinking is a humble curation of my foraging in the digital environment. My purpose is to pick interesting pieces, based on my own curiosity (and the curiosity of the many interesting people I follow), about developments in some key domains (work, organization, social-economy, intelligence, domestication of DNA, energy, etc.)  that suggest we are in the midst of a change in the conditions of change - a phase-transition. That tomorrow will be radically unlike yesterday.

Many thanks to those who enjoy this.

In the 21st Century curiosity will SKILL the cat.

Jobs are dying - Work is just beginning.
Work that engages our whole self becomes play that works.
Techne = Knowledge-as-Know-How :: Technology = Embodied Know-How  
In the 21st century - the planet is the little school house in the galaxy.
Citizenship is the battlefield of the 21st  Century

“Be careful what you ‘insta-google-tweet-face’”
Woody Harrelson - Triple 9



Content
Quotes:


Articles:




In a Puzzling Puzzle:
1. The pieces are not supplied; some of them have to be found, others invented.
2. These pieces usually appear obscure, not clean-cut—more like fragments.
3. These fragments rarely connect neatly.
4. With no box in sight, the fragments have to create the picture.


Our profound puzzle Pat solutions can no more resolve puzzling puzzles than can Monopoly develop entrepreneurs or chess train guerrilla fighters.


at the root of our most foreboding problems—climate change, income disparities, declining democracy, nuclear weapons in the hands of loose cannons—lies the imbalance that plagues our societies. Narrow economic forces, manifested in rampant individualism and unrestrained globalization, have been overwhelming our collective and communal needs. This is our profound puzzle, for which pat solutions, such as fixing capitalism, will not work.

Making Progress on our Puzzle



numerous studies over the past few decades have reached what seems a counterintuitive conclusion: that all psychotherapies have roughly equal effects. This is known as the ‘dodo bird verdict’ – named after a character in Alice in Wonderland (1865) who declares after a running contest: ‘Everybody has won and all must have prizes.’ That no single form of therapy has proved superior to others might come as a surprise to readers, but it’s mightily familiar to researchers in the field. ‘There is so much data for this conclusion that if it were not so threatening to specific theories it would long ago have been accepted as one of psychology’s major findings,’ writes Arthur Bohart, professor emeritus at California State University, Dominguez Hills, and author of several books on psychotherapy.


the deeper reason why no single psychotherapy seems to provide unique advantages over any other is that they all work because of shared elements. Chief among these is the therapeutic relationship, connected to positive outcomes by a wealth of evidence. The emotional bond and the collaboration between client and therapist – called the alliance – have emerged as a strong predictor of improvement, even in therapies that don’t emphasise relational factors. Until recently, most studies of this alliance could show only that it correlates with better mental health in clients, but advances in research methods now find evidence for a causal link, suggesting that the therapy relationship might indeed be healing. Similarly, research into the traits of effective therapists has revealed that their greater experience with or a stricter adherence to a specific approach do not lead to improved outcomes whereas empathy, warmth, hopefulness and emotional expressiveness do.

Cradled by therapy



“The world was genetically complex 50,000 to 100,000 years ago,” says paleoanthropologist Bernard Wood of George Washington University in Washington, D.C. Wood suspects that three or four closely related Homo species, including Denisovans, interbred during that time.

Mysterious Denisovans emerged from the shadows in 2019




The direct descendants of the first Melanesian Homo sapiens, Papuans have conserved in their cells, more so than any other humans on the planet, the traces of mankind’s first journey to the edge of the world. Once they arrived at the end of their odyssey, these early Melanesians, with only a few exceptions, never left their remote land. Over the centuries, while other Sapiens in Asia and Europe were intermixing, blurring the traces of their migrations, the genome of the first Papuans, which is the same as that of the first Australian Aborigines, has remained essentially intact. With a unique genetic heritage incorporating 2 to 4% Neanderthal and 4 to 6% Denisovan genes, the Papuans are nothing less than the living record of our origins.

The Papuans, the Living Record of our Origins



Many works of literary fiction claim to be set in the present day. In fact, they take place in the recent past, conjuring a world that feels real because it’s familiar, and therefore out of date. Gibson’s strategy of extreme presentness reflects his belief that the current moment is itself science-fictional. “The future is already here,” he has said. “It’s just not very evenly distributed.”


“It isn’t an intellectual process, and it’s not prescient—it’s about what I can bring myself to believe.”


In writing “The Peripheral,” he’d been able to bring himself to believe in the reality of an ongoing slow-motion apocalypse called “the jackpot.” A character describes the jackpot as “multicausal”—“more a climate than an event.” The world eases into it gradually, as all the bad things we worry about—rising oceans, crop failures, drug-resistant diseases, resource wars, and so on—happen, here and there, to varying degrees, over the better part of the twenty-first century, adding up to “androgenic, systemic, multiplex, seriously bad shit” that eventually kills eighty per cent of the human race. It’s a Gibsonian apocalypse: the end of the world is already here; it’s just not very evenly distributed.


For us, of course, things can change so abruptly, so violently, so profoundly, that futures like our grandparents’ have insufficient “now” to stand on. We have no futures because our present is too volatile. . . . We have only risk management. The spinning of the given moment’s scenarios. Pattern recognition.


In a hyperconnected world, patterns can repeat in different idioms. The same ripples flow across Asia and Europe, art and technology, war and television. 

How William Gibson Keeps His Science Fiction Real



I generally don’t post much about current politics - although I do follow them. This is a great signal about the use of frames, narratives and metaphors through an analysis of Trump by George Lakoff - a must read cognitive scientist.

Trump has turned words into weapons and he’s winning the linguistic war

Language works by activating brain structures called “frame-circuits” used to understand experience. They get stronger when we hear the activating language. Enough repetition can make them permanent, changing how we view the world.
Even negating a frame-circuit activates and strengthens it, as when Nixon said “I am not a crook” and people thought of him as a crook.


Scientists, marketers, advertisers and salespeople understand these principles. So do Russian and Islamic State hackers. But most reporters and editors clearly don’t. So the press is at a disadvantage when dealing with a super salesman with an instinctive ability to manipulate thought by 1) framing first, 2) repeating often and 3) leading others to repeat his words by getting people to attack him within his own frame.


Language can shape the way we think. Trump knows this. Here are some of his favorite manipulation techniques.

This is a good summary of the accelerating advances in science and technology. Worth the read.

The scientific events that shaped the decade

The 2010s have seen breakthroughs in frontiers from gene editing to gravitational waves. The coming one must focus on climate change.
Scientific and technological innovation has always created social and economic transformation. But the past decade showed, as few others have, the speed and scale at which such change can happen. If it continues at the present rate, the shape of the next ten years — from information technologies to applied bioscience, energy and environment — looks ever more contingent on the discoveries made in that time.


In the 2010s, artificial intelligence (AI) finally began to reveal its remarkable power and disruptive potential. Driven mainly by the advent of deep learning — the use of neural networks to spot patterns in complex data – AI flexed its muscles by achieving reliable language translation, besting expert human players at poker, video games and the board game Go, and beginning to demonstrate its use in self-driving cars 


Few fields are untouched by the machine-learning revolution, from materials science to drug exploration; quantum physics to medicine. Moreover, it now cannot be doubted that many jobs currently performed by humans could be done more cheaply and efficiently by machines — and the transition might well come sooner than we expect.

This is a concise summary of that past year’s advances in Math.

The Year in Math and Computer Science

Mathematicians and computer scientists made big progress in number theory, graph theory, machine learning and quantum computing, even as they reexamined our fundamental understanding of mathematics and neural networks.
For mathematicians and computer scientists, this was often a year of double takes and closer looks. Some reexamined foundational principles, while others found shockingly simple proofs, new techniques or unexpected insights in long-standing problems. Some of these advances have broad applications in physics and other scientific disciplines. Others are purely for the sake of gaining new knowledge (or just having fun), with little to no known practical use at this time.


Quanta covered the decade-long effort to rid mathematics of the rigid equal sign and replace it with the more flexible concept of “equivalence.” We also wrote about emerging ideas for a general theory of neural networks, which could give computer scientists a coveted theoretical basis to understand why deep learning algorithms have been so wildly successful.


Meanwhile, ordinary mathematical objects like matrices and networks yielded unexpected new insights in short, elegant proofs, and decades-old problems in number theory suddenly gave way to new solutions. Mathematicians also learned more about how regularity and order arise from chaotic systems, random numbers and other seemingly messy arenas. And, like a steady drumbeat, machine learning continued to grow more powerful, altering the approach and scope of scientific research, while quantum computers (probably) hit a critical milestone.

This is a great summary of some of the progress toward domestication of DNA.
CRISPR/Cas9 is a bacterial defense system against viruses that scientists have repurposed to make precise changes to DNA in the cells of humans and other animals. A “guide RNA” tows the DNA-cutting enzyme Cas9 to specific genes, where it slices through the DNA. In three clinical trials now under way in the United States, and one just completed, those cuts are disabling genes or snipping out problem bits of DNA.

The first U.S. trials in people put CRISPR to the test in 2019

These studies are a first step toward fulfilling the gene editor’s medical promise
When it was unveiled in 2012, people had great hopes that the gene editor CRISPR/Cas9 could treat or even cure hundreds to thousands of genetic diseases. This year, researchers in the United States began testing the gene editor in people, a crucial first step in determining whether the technology can fulfill its medical promise.


These first clinical trials are testing CRISPR/Cas9’s safety and efficacy against cancer, blood disorders and one form of inherited blindness in people who already have the disease. Many more such trials are expected to begin soon. Unlike the editing of human embryos that stirred up controversy in 2018, the genetic changes introduced in these trials would not be inherited by future generations.


CRISPR’s rise as a potential medical tool happened in remarkably short time, says Janelle Waack, an intellectual property attorney at the law firm Bass, Berry & Sims in Washington, D.C. She has been tracking the dramatic growth of CRISPR patent filings, including for health care, medical research, agriculture and chemical processing. “People are investing in the technology and think it has great commercial value,” she says.

This is a fascinating signal of an emerging understanding of how mechanical-physical actions within and between cells complement chemical actions - and also progress the domestication of DNA
Originally considered a novelty, technologists rushed to make increasingly complex shapes, such as smiley faces, snowflakes, a tiny world map, and more recently, the world’s smallest playable tic-tac-toe set. It wasn’t just fun. Along the way, scientists uncovered sophisticated principles and engineering techniques to shape DNA strands into their desired structures, forming a blueprint of DNA engineering.
As costs keep dropping, the authors believe we’ll witness even more creative and sophisticated DNA nanomachines.

DNA Nanomachines Are Opening Medicine to the World of Physics

When I imagine the inner workings of a robot, I think hard, cold mechanics running on physics: shafts, wheels, gears. Human bodies, in contrast, are more of a contained molecular soup operating on the principles of biochemistry.


Yet similar to robots, our cells are also attuned to mechanical forces—just at a much smaller scale. Tiny pushes and pulls, for example, can urge stem cells to continue dividing, or nudge them into maturity to replace broken tissues. Chemistry isn’t king when it comes to governing our bodies; physical forces are similarly powerful. The problem is how to tap into them.


In a new perspectives article in Science, Dr. Khalid Salaita and graduate student Aaron Blanchard from Emory University in Atlanta point to DNA as the solution. The team painted a futuristic picture of DNA mechanotechnology, in which we use DNA machines to control our biology. Rather than a toxic chemotherapy drip, for example, a cancer patient may one day be injected with DNA nanodevices that help their immune cells better grab onto—and snuff out—cancerous ones.


“For a long time,” said Salaita, “scientists have been good at making micro devices, hundreds of times smaller than the width of a human hair. It’s been more challenging to make functional nano devices, thousands of times smaller than that. But using DNA as the component parts is making it possible to build extremely elaborate nano devices because the DNA parts self-assemble.”


Just as the steam engine propelled civilization through the first industrial revolution, DNA devices may fundamentally change medicine, biological research, and the development of biomaterials, further merging man and machine.

This probably shouldn’t surprise anyone - but IKEA is transforming itself from a technology company into a technology company. :)

IKEA 2.0

The Swedish furniture giant has conquered living rooms, bedrooms, and bathrooms — but can it hang on to the future of the home?
At first, Ikea treated smart home stuff like a hobby — testing the waters with furniture that could wirelessly charge your phone before building an ecosystem of speakers, lights, and blinds with bare-bones functionality. Those successes prompted a decision this summer to promote Home Smart to the same importance as Living Room, Bedroom, and all of the other Ikea businesses that have come to define the company.


Early reviews of the company’s Home Smart ecosystem mirror the typical Ikea experience: great price, questionable quality. It’s an inauspicious start for a company that tried and failed to take on the tech world before. Ikea now faces the challenge of teaming up with Google, Amazon, Apple, and other tech giants while also battling them for primacy in the home.


Ikea believes its advantage in the smart home stems from what at first looks like its greatest disadvantage: Ikea is not a tech company. As a furniture maker, Ikea has a thorough understanding of life at home and a unique ability to marry technology with ordinary furniture. Ikea’s unimaginable scale matches up well with Big Tech. And historically speaking, it’s been a formidable and ruthless competitor in every segment it focuses on. Ikea is now focused on the smart home.


The digital transformation of Ikea could improve the lives of billions. At stake is the democratization of the smart home — intelligent homes that improve the daily lives of everyone, not just the resident geeks who can already afford them.

This is not Iron Man yet - but it signals the emergence of new forms of augmenting human effort. The GIFs and 2 min video provide good visuals.

Sarcos Demonstrates Powered Exosuit That Gives Workers Super Strength

It won't make you look like Iron Man but the Guardian XO allows you to lift 200 pounds without breaking a sweat
One year ago, for IEEE Spectrum’s special report on the Top Tech for 2019, Sarcos Robotics promised that by the end of the year they’d be ready to ship a powered exoskeleton that would be the future of industrial work. And late last month, Sarcos invited us to Salt Lake City, Utah, to see what that future looks like.


Sarcos has been developing powered exoskeletons and the robotic technologies that make them possible for decades, and the lobby of the company’s headquarters is a resting place for concepts and prototype hardware that’s been abandoned along the way. But now, Sarcos is ready to unveil the prototype of the Guardian XO, a strength-multiplying exoskeleton that’s about to begin shipping.


The Sarcos Guardian XO is a 24-degrees-of-freedom full-body robotic exoskeleton. While wearing it, a human can lift  200 pounds (90 kilograms) while feeling like they’re lifting just 10 lbs (4.5 kg). The Guardian XO is fully electrical and untethered with a runtime of 2 hours, and hot-swappable battery packs can keep it going for a full work day. It takes seconds to put on and take off, and Sarcos says new users can be trained to use the system in minutes. One Guardian XO costs $100,000 per year to rent, and the company will be shipping its first batch of alpha units to customers (including both heavy industry and the U.S. military) in January.

Here is an important signal that fundamental science has so much more to reveal.

Discovering a new fundamental underwater force

A team of mathematicians from the University of North Carolina at Chapel Hill and Brown University has discovered a new phenomenon that generates a fluidic force capable of moving and binding particles immersed in density-layered fluids. The breakthrough offers an alternative to previously held assumptions about how particles accumulate in lakes and oceans and could lead to applications in locating biological hotspots, cleaning up the environment and even in sorting and packing.


How matter settles and aggregates under gravitation in fluid systems, such as lakes and oceans, is a broad and important area of scientific study, one that greatly impacts humanity and the planet. Consider "marine snow," the shower of organic matter constantly falling from upper waters to the deep ocean. Not only is nutrient-rich marine snow essential to the global food chain, but its accumulations in the briny deep represent the Earth's largest carbon sink and one of the least-understood components of the planet's carbon cycle.


Ocean particle accumulation has long been understood as the result of chance collisions and adhesion. But an entirely different and unexpected phenomenon is at work in the water column, according to a paper published Dec. 20 in Nature Communications by a team led by professors Richard McLaughlin and Roberto Camassa of the Carolina Center for Interdisciplinary Applied Mathematics in the College of Arts & Sciences, along with their UNC-Chapel Hill graduate student Robert Hunt and Dan Harris of the School of Engineering at Brown University.


In the paper, the researchers demonstrate that particles suspended in fluids of different densities, such as seawater of varying layers of salinity, exhibit two previously undiscovered behaviors. First, the particles self-assemble without electrostatic or magnetic attraction or, in the case of micro-organisms, without propulsion devices such as beating flagella or cilia. Second, they clump together without any need for adhesive or other bonding forces. The larger the cluster, the stronger the attractive force.

A great signal for all those of us who LOVE hot sauce and hot peppers.
An interesting fact is that protection from mortality risk was independent of the type of diet people followed. In other words, someone can follow the healthy Mediterranean diet, someone else can eat less healthily, but for all of them, chili pepper has a protective effect.

Consumption of chili pepper cuts down the risk of death from a heart or cerebral attack

Chili pepper is a common ingredient in Italians kitchens, and over the centuries, it has been praised for its supposed therapeutic virtues. Now, an Italian study shows that people who consume it on a regular basis have an all-cause mortality risk 23 percent lower than those who do not consume it. The study, published in the Journal of the American College of Cardiology (JACC), was conducted by the Department of Epidemiology and Prevention of I.R.C.C.S. Neuromed in Pozzilli, Italy, in collaboration with the Department of Oncology and Molecular Medicine of the Istituto Superiore di Sanità in Rome, the University of Insubria in Varese and the Mediterranean Cardiocentro in Naples.


The study examined 22,811 citizens of the Molise region in Italy participating in the Moli-sani study. Following their health status for an average period of about eight years and comparing it with their eating habits, Neuromed researchers observed that in people regularly consuming chili pepper (four times a week or more), the risk of dying of a heart attack was cut by 40 percent. Risk reduction for cerebrovascular mortality was more than halved.