Thursday, September 12, 2019

Friday Thinking 13 Sept 2019

Friday Thinking is a humble curation of my foraging in the digital environment. My purpose is to pick interesting pieces, based on my own curiosity (and the curiosity of the many interesting people I follow), about developments in some key domains (work, organization, social-economy, intelligence, domestication of DNA, energy, etc.)  that suggest we are in the midst of a change in the conditions of change - a phase-transition. That tomorrow will be radically unlike yesterday.

Many thanks to those who enjoy this.

In the 21st Century curiosity will SKILL the cat.

Jobs are dying - Work is just beginning.
Work that engages our whole self becomes play that works.
Techne = Knowledge-as-Know-How :: Technology = Embodied Know-How  
In the 21st century - the planet is the little school house in the galaxy.
Citizenship is the battlefield of the 21st  Century

“Be careful what you ‘insta-google-tweet-face’”
Woody Harrelson - Triple 9


Content
Quotes:

Articles:



Fixing Private Sector Capitalism?  The popular solution in the United States is to fix capitalism. Proposals abound for what can be called adjectival capitalism: Progressive Capitalism, Breakthrough Capitalism, Caring Capitalism, Conscious Capitalism, Inclusive Capitalism, Regenerative Capitalism, Sustainable Capitalism, and best of all, Democratic Capitalism (capitalism being the noun, democracy the adjective). Methinks that capitalism doth propose too much. How in the world did this word capitalism, essentially about the funding of private enterprises, become the be all and end all of human existence? (Ask an economist.)

A society can stand tall when it is supported by the solid legs of respected governments in the public sector, responsible businesses in the private sector, and robust communities in the plural sector.

What is this plural sector? It is all those associations that are neither public nor private—owned neither by the state nor by private investors. Some are owned by their members, as in cooperatives; others are owned by no-one, such as NGOs, clubs, foundations, charities, religious orders, and not-for-profit hospitals, many of these community-based. Alexis de Tocqueville referred to them as associations in his 1830s volumes on Democracy in America, and recognized the key role they were playing in sustaining the new democracy.

We too are the plural sector, each of us and all of us, in our social lives. Many of us work in the private sector and most of us vote in the public sector but all of us live in the plural sector. (How many of its associations figured in your life last week—say, shopping in a co-op, working out at the Y, attending a “private” university, maybe even marching in a protest?)

Thus, the plural sector is huge, far larger than most people recognize.

Donald Trump is not the problem - REGAINING BALANCE




Our early use of symbols helped forge powerful bonds and rules of cooperation, as human societies grew increasingly complex and competitive. A recent study by Ara Norenzayan of the University of British Columbia and Azim Shariff of the University of Oregon revealed that, across 186 societies, the larger the typical social group, the more likely it was the culture created a god who monitored and judged human morality—perhaps the ultimate symbol of rule enforcement.

Metaphors Are Us




In Rajasthan, there still exists the ‘cow dust hour’ to describe the melancholy of evenings when cattle return from a day’s grazing, awash in a film of dust; Michael Ondaatje describes it in a poem: ‘It is the hour we move small / in the last possibilities of light.’ For the traditional Japanese, the year was divided into 72 microseasons called ‘kō’ each of which lasts for five days (the days of 16 to 20 March are when ‘caterpillars become butterflies’). These are gradations of time long enough to be memorable but short enough to remind us how fleeting the present is – a time was born from intuitions, from regularities of nature, from injunctions in scripture, and from the needs of agriculture.

How time stopped circling and percolating and started running on tracks




Artists across Europe took note of the changed atmosphere. William Turner drew vivid red skyscapes that, in their coloristic abstraction, seem like an advertisement for the future of art. Meanwhile, from his studio on Greifswald Harbor in Germany, Caspar David Friedrich painted a sky with a chromic density that—one scientific study has found—corresponds to the “optical aerosol depth” of the colossal volcanic eruption that year.

For three years following Tambora’s explosion, to be alive, almost anywhere in the world, meant to be hungry. In New England, 1816 was nicknamed the “Year Without a Summer” or “Eighteen-Hundred-and-Froze-to-Death.” Germans called 1817 the “Year of the Beggar.” Across the globe, harvests perished in frost and drought or were washed away by flooding rains. Villagers in Vermont survived on porcupine and boiled nettles, while the peasants of Yunnan in China sucked on white clay. Summer tourists traveling in France mistook beggars crowding the roads for armies on the march.

One such group of English tourists, at their lakeside villa near Geneva, passed the cold, crop-killing days by the fire exchanging ghost stories. Mary Shelley’s storm-lashed novel Frankenstein bears the imprint of the Tambora summer of 1816, and her literary coterie—which included the poets Percy Shelley and Lord Byron—serve as tour guides through the suffering worldscape of 1815–18.

The Volcano That Shrouded the Earth and Gave Birth to a Monster




Legendary science fiction editor Gardner Dozois once said that the job of a science fiction writer was to notice the car and the movie theater and anticipate the drive-in – and then go on to predict the sexual revolution. I love that quote, because it highlights the key role of SF in examining the social consequences of technology – and because it shows how limited our social imaginations are. Today, we might ask the SF writer to also predict how convincing the nation’s teenagers to carry a piece of government-issued photo ID (a driver’s license) as a precondition for participating in the sexual revolution set the stage for the database nation, the idea that people are the sort of thing that you count and account for, with the kind of precision that the NSA is now understood to bring to the problem.

The thing I treasure about science fiction is its utility as a toolkit for thinking about the relationship between technological change and human beings. This is why I value ‘‘design fiction’’ so much: an architect might make a visualization that flies you through her as-yet-unbuilt building, an engineer might build a prototype to show you what he’s thinking of inventing, but through design fiction, a writer can take you on a tour of how a person living with that technology might feel. That’s the kind of contribution to the discussion about which technology we should make, and how we should use it, that can make all the difference.

Cory Doctorow: Cold Equations and Moral Hazard




It is not growing throughput that is ultimately the problem: the problem is the growth imperative itself. To illustrate, one can imagine that in an economy where growth must happen despite a cap on throughput, and where all new value therefore has to be immaterial, capital would seek to enclose immaterial commons that are presently abundant and free (knowledge, songs, green spaces, maybe even parenting, physical touch, love, and perhaps even the air itself) and sell them back to people for money. Subject to these new waves of artificial scarcity, people would find themselves compelled to work and earn wages in the new immaterial industries simply in order to acquire immaterial goods that used to be freely available. This may be an ecological economy, but it is not an economy that makes any sense, or one that anyone would actually want to live in.

The point of this imaginary exercise is to illustrate that while capping throughput might create the conditions for an ecological economy and indeed cause material and energy throughput to decline, it does not neutralize the deeper violence of the juggernaut, which is the logic of growth itself. Such a move might be adequate in a pragmatic sense, but it is intellectually unsatisfying. The only way to resolve the Lauderdale Paradox is to reverse it: to reorganize the economy around generating an abundance of public wealth even if doing so comes at the expense of private riches. This would liberate humans from the pressures generated by artificial scarcity, thus neutralizing the juggernaut and releasing the living world from its grip.

Degrowth: a theory of radical abundance





This is a good article regarding the emerging population age pyramid shift.
“You need a lot of change to take advantage of the opportunities,” said Maurizio Bussolo, a World Bank economist and co-author of the report. But he added, “We can actually change demography itself.”

World Bank: Policy shifts can mitigate gray tsunami as population ages

As the planet's population gets older, there are fears that a gray tsunami may make the possibility of golden aging more remote. But a World Bank report released Tuesday says global aging isn't an unstoppable force and can be compensated for by policy initiatives.

By 2100, the world population is expected to increase from 7.3 billion to 10.9 billion and the share of older people is increasing, raising concerns about healthcare, sustainability of pension systems, inter-generational conflicts and a negative impact on economic growth and productivity.

While the report, Golden Aging, Prospects for Healthy, Active and Prosperous Aging in Europe and Central Asia, says there are challenges as populations get older, there are still opportunities for governments, individuals and the private sector to collectively forge a prosperous and healthy “Golden Age.”


There is a growing interest in the use of natural and synthetic psychedelics to explore ways to treat some mental and mood disorders. This is another significant signal of a change towards this.
“Psychedelics are a fascinating class of compounds,” said Roland Griffiths, the center’s director and a professor of behavioral biology in the Hopkins School of Medicine.
“They produce unique and profound change in consciousness," he said. “The center will allow us to expand on research to develop new treatments for a wide variety of psychiatric disorders. And it will allow us to extend on past research in healthy people to improve their sense of well being.”

Johns Hopkins opening a new psychedelic research center, studying use of ‘magic mushrooms’ and more

Johns Hopkins Medicine is launching a new psychedelic research center where scientists will test the potential of so-called magic mushrooms and other drugs to treat some of the toughest mental health and addiction challenges.

The center, announced Wednesday, is believed to be the first center in the United States and the largest in the world to focus on drugs still better known as symbols of 1960s counterculture than serious medicine.

The Center for Psychedelic and Consciousness Research at Johns Hopkins Medicine is being funded by a $17 million donation from a group of private donors. Since federal funding cannot be used for such research, the center needs private support.

The Hopkins center’s research will focus on applications of the drugs for treating opioid addiction, Alzheimer’s disease, post-traumatic stress disorder, eating disorders and depression, among other diseases.


This is an interesting signal - part of domesticating DNA - but also a discovery that could accelerate the bio-economy and bio-manufacturing. Plants not only make many wonderful medicines - they are also powerful chemical-warfare producers.

Key enzyme found in plants could guide development of medicines and other products

Plants can do many amazing things. Among their talents, they can manufacture compounds that help them repel pests, attract pollinators, cure infections and protect themselves from excess temperatures, drought and other hazards in the environment.

Researchers from the Salk Institute studying how plants evolved the abilities to make these natural chemicals have uncovered how an enzyme called chalcone isomerase evolved to enable plants to make products vital to their own survival. The researchers' hope is that this knowledge will inform the manufacture of products that are beneficial to humans, including medications and improved crops. The study appeared in the print version of ACS Catalysis on September 6, 2019.

As an enzyme, chalcone isomerase acts as a catalyst to accelerate chemical reactions in plants. It also helps to ensure the chemicals that are made in the plant are the proper form, since molecules with the same chemical formula can take two different variations that are mirror images of each other (called isomers).

"By understanding chalcone isomerase, we can create a new toolset that chemists will be able to use for the reactions they're studying," Noel says. "It's absolutely vital to have this kind of foundational knowledge to be able to design molecular systems that can carry out a particular task even in the next generation of nutritionally dense crops capable of transforming the greenhouse gas carbon dioxide into molecules essential for life."


This is an interesting research finding - which could signal that any more people could benefit from psychological help that one would expect.
"Given the cost of sleep disorders, including insomnia, to every economy and society in the world, it's another important step towards managing this endemic problem in the community," 
"This first study is important because we don't know exactly the childhood or early-life factors that potentially influence this outcome of insomnia and finding these connections could reduce sleep disorders in the future."

Disturbed childhood can lead to adult insomnia

Parents should help their children with better sleep patterns, along with any problem behavioural issues, because this can lead to severe insomnia in middle age, a groundbreaking new study shows.

Published in JAMA Network Open journal today, Australian researchers have used data from a long-running UK population study to find links between moderate to severe childhood behavioural problems and insomnia in adults by the age of 42 years old.

Insomnia is the most common sleep disorder in adults, estimated to affect almost one in three people. Chronic insomnia is associated with an increased risk of mental health and other health, wellbeing and economic consequences including working capacity.

The United Kingdom 1970 Birth Cohort Study is a large-scale study of more than 16,000 babies born in a single week. The current study includes people from the cohort aged 5 (8550 participants), 10 (9090 people) and 16 years (7653) followed up to age 42 years (2012). Statistical analysis was performed from February 1 to July 15, 2019.


This is on ‘killer drone’ that may help transform agriculture.

Meet The Army Of Chinese Crop-Protecting-Drones With A 98% Kill-Rate

The drone manufacturer, XAG, who is based in Guangzhou, has teamed up with Germany's Bayer Crop Science in a collaborative effort to rid China of the fall armyworm. The drone devices are sporting low-toxicity insecticide and have also successfully managed the pests in a government-led initiative in the southwest province of Yunnan. Drones have also "effectively controlled" the spread of pests in cornfields in Henan province. 

XAG said of the armyworm:
"It is the ‘crop-devouring monster’ that attacks over 80 crop varieties. Most farmers resort to traditional insecticide sprayers, which not only fail to move fast enough against the ravenous, fast-moving fall armyworm that can fly up to 100 kilometers in one night, but also expose them to dangerous chemicals."

The drones can operate after sunset, which is beneficial since the armyworm feeds actively at night. 
The armyworm, known for devouring crops, has spread from the Americas to Africa and Asia, eating corn, rice, vegetables and cotton along the way. Since its unceremonious arrival in China, it has affected 950,000 hectares of crops spanning 24 provinces, including Hebei, Shaanxi and Shandong. Outbreaks at 90% of the affected areas are now under control.


This is definitely a strong signal of change that should happen - and likely will.
“People put things in refrigerators with the best intentions, while letting them, the majority of time, live slow, miserable deaths,” says Brian Roe, professor at Ohio State University, who has studied matters of food for more than 20 years.

There’s a $218 billion design problem sitting in your fridge right now

We could save up to 30% of food waste by changing expiration dates. So why don’t we?
There’s a nice piece of fruit in your refrigerator right now. Perhaps it’s a veggie. Or a boneless skinless chicken breast. Whatever it is, you’re definitely going to eat it. You’re not a food waster! But here’s the truth: There’s only a 50% chance, or worse, that you’ll finish any of those things, in their entirety, a week later. The rest will only be partially eaten, or perhaps prepared and sitting in your fridge as leftovers. In any case, much of that remaining 50% will end up in the trash soon, representing lost money and one of the greatest contributors to carbon emissions and climate change.

In the U.S., we waste as much as $218 billion on uneaten food every year when analyzing the entire supply chain, including farming and processing. Globally, the carbon emitted by wasted food can be classified as its own country—the third worst carbon emitter in the world, behind the U.S. and China.

Sometimes things do just rot before we eat them! But often, food is tossed because of a more confounding culprit: the expiration label. According to Roe’s most recent paper, published in Resources, Conservation, & Recycling, those “best by” dates on packages are the third most-common reason we throw away food in our fridge.


Nature is stranger than fiction - and evolution is full of surprises.
 during a small experimental fire, a wind change enveloped de Langer in thick smoke. With watering eyes, he realized that smoke might be the mysterious phoenix factor that would coax the seeds to life. By 1990 he had shown puffing smoke onto soil germinated his rare species in astonishing numbers.

What home gardeners can learn from nature's rebirth after fire

A startling phenomenon occurs after a bushfire tears through a landscape. From the blackened soil springs an extraordinary natural revival—synchronized germination that carpets the landscape in flowers and colour.

So what is it in bushfires that gives plants this kiss of life? The answer is smoke, and it is increasingly transforming everything from large-scale land regeneration to nurseries and home gardening.

Burnt plants survive bushfires in various ways. Some are protected by woody rootstocks and bark-coated stems; others resprout from underground buds. But most plants awaken their soil seed bank, which may have lain dormant for decades, or even a century.

However, this smoke-induced seed germination is not easily replicated by humans trying to grow the plants themselves. Traditionally, many native Australian flora species—from fringe-lilies to flannel flowers and trigger plants—could not be grown easily or at all from seed.

The technique is simple. Create a smoldering fire of dry and green leafy material and pass the smoke into an enclosed area where seed has been sown into seed trays or spread as a thin layer. Leave for one hour and water sparingly for ten days to prevent the smoke from washing out of the seed mix. The rest is up to nature.


I am still waiting for the ability to use stem cells to regrow teeth that was ten years away at least ten years ago. However, this is an important improvement for dealing with cavities than our current approach. Hopefully regrow teeth remains on the horizon of possible treatment.

Can we heal teeth? The quest to repair tooth enamel, nature's crystal coat

In a significant scientific breakthrough, researchers recently discovered a way to regrow human tooth enamel.
Scientists from China have invented a gel that contains mineral clusters naturally found in teeth. In partially acid-damaged teeth, the gel stimulates crystal regrowth to restore tooth enamel back to its original structure.

While the method is yet to be tested on people, one day this could mean saying goodbye to painful needles, the dreaded dentist drill, and even fillings.

While this technology is something to look forward to, the short answer for now is "not yet." This study has only been performed on extracted teeth. The researchers are hoping to test their method on mice, and then people soon after.

One of the significant limitations to moving towards animal and human trials is the toxicity of the essential ingredient, TEA. Another challenge is the enamel thickness they were able to repair was at a microscopic level.


This is definitely a weak signal - but an important one to watch. As Ray Kurzweil has noted we are living in an age whereby the longer one lives - the longer one may be able to live.
“I’d expected to see slowing down of the clock, but not a reversal,” says geneticist Steve Horvath at the University of California, Los Angeles, who conducted the epigenetic analysis. “That felt kind of futuristic.” 

First hint that body’s ‘biological age’ can be reversed

In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’, which tracks a person’s biological age.
A small clinical study in California has suggested for the first time that it might be possible to reverse the body’s epigenetic clock, which measures a person’s biological age.

For one year, nine healthy volunteers took a cocktail of three common drugs — growth hormone and two diabetes medications — and on average shed 2.5 years of their biological ages, measured by analysing marks on a person’s genomes. The participants’ immune systems also showed signs of rejuvenation.

The results were a surprise even to the trial organizers — but researchers caution that the findings are preliminary because the trial was small and did not include a control arm.
The findings were published on 5 September in Aging Cell.


This is a strong signal of an inevitable approach to bring medical treatments to more people farther away from medical centers.

First long-distance heart surgery performed via robot

In a feat of networking, engineering, and medicine, a doctor performed a heart procedure while standing 20 miles from his patient.
A doctor in India has performed a series of five percutaneous coronary intervention (PCI) procedures on patients who were 20 miles away from him. The feat was pulled off using a precision vascular robot developed by Corindus. The results of the surgeries, which were successful, have just been published in EClinical Medicine, a spin-off of medical journal The Lancet.

The feat is an example of telemedicine, an emerging field that leverages advances in networking, robotics, mixed reality, and communications technologies to beam in medical experts to remote locations for everything from consultations to surgical procedures. Telemedicine, which could decentralize healthcare by distributing doctors into local communities virtually, could ease shortages of nurses and doctors and potentially cut healthcare costs. In France, people are already visiting Telehealth cabins for fast, convenient healthcare. During the recent Ebola crisis, the University of Virginia delivered care in parts of Africa via telemedicine. 


One way to live longer and better is through repairing parts that no longer work. This is a good signal of progress toward that goal.
"Our SWIFT biomanufacturing method is highly effective at creating organ-specific tissues at scale from OBBs ranging from aggregates of primary cells to stem-cell-derived organoids," said corresponding author Jennifer Lewis, Sc.D., who is a Core Faculty Member at the Wyss Institute as well as the Hansjörg Wyss Professor of Biologically Inspired Engineering at SEAS. "By integrating recent advances from stem-cell researchers with the bioprinting methods developed by my lab, we believe SWIFT will greatly advance the field of organ engineering around the world."

A swifter way towards 3-D-printed organs

Twenty people die every day waiting for an organ transplant in the United States, and while more than 30,000 transplants are now performed annually, there are over 113,000 patients currently on organ waitlists. Artificially grown human organs are seen by many as the "holy grail" for resolving this organ shortage, and advances in 3-D printing have led to a boom in using that technique to build living tissue constructs in the shape of human organs. However, all 3-D-printed human tissues to date lack the cellular density and organ-level functions required for them to be used in organ repair and replacement.

Now, a new technique called SWIFT (sacrificial writing into functional tissue) created by researchers from Harvard's Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences (SEAS), overcomes that major hurdle by 3-D printing vascular channels into living matrices composed of stem-cell-derived organ building blocks (OBBs), yielding viable, organ-specific tissues with high cell density and function. The research is reported in Science Advances.

"This is an entirely new paradigm for tissue fabrication," said co-first author Mark Skylar-Scott, Ph.D., a Research Associate at the Wyss Institute. "Rather than trying to 3-D-print an entire organ's worth of cells, SWIFT focuses on only printing the vessels necessary to support a living tissue construct that contains large quantities of OBBs, which may ultimately be used therapeutically to repair and replace human organs with lab-grown versions containing patients' own cells."


Another signal of the importance of our microbial ecology for maintaining a robust immune capacity.

Individual response to flu vaccine influenced by gut microbes

A new study in healthy adults suggests that antibiotics may reduce the effectiveness of the flu vaccine.
The depletion of gut bacteria by antibiotics appears to leave the immune system less able to respond to new challenges, such as exposure to previously unencountered germs or vaccines, said Bali Pulendran, Ph.D., professor of pathology and of microbiology and immunology at the Stanford University School of Medicine.

"To our knowledge, this is the first demonstration of the effects of broad-spectrum antibiotics on the immune response in human—in this case, our response to vaccination—directly induced through the disturbance of our gut bacteria," he said.

The study will be published Sept. 5 in Cell. Pulendran, who holds the Violetta L. Horton Professorship, is the senior author. Lead authorship is shared by Stanford postdoctoral scholars Thomas Hagan, Ph.D., and Mario Cortese, Ph.D.; and Nadine Rouphael, MD, Ph.D., associate professor of medicine and infectious disease at Emory University.


This article is over a month old - but for those who may not have read about it.
The whistleblower said: “There have been countless instances of recordings featuring private discussions between doctors and patients, business deals, seemingly criminal dealings, sexual encounters and so on. These recordings are accompanied by user data showing location, contact details, and app data.”

Apple contractors 'regularly hear confidential details' on Siri recordings

Workers hear drug deals, medical details and people having sex, says whistleblower
Apple contractors regularly hear confidential medical information, drug deals, and recordings of couples having sex, as part of their job providing quality control, or “grading”, the company’s Siri voice assistant, the Guardian has learned.

Although Apple does not explicitly disclose it in its consumer-facing privacy documentation, a small proportion of Siri recordings are passed on to contractors working for the company around the world. They are tasked with grading the responses on a variety of factors, including whether the activation of the voice assistant was deliberate or accidental, whether the query was something Siri could be expected to help with and whether Siri’s response was appropriate.

Apple says the data “is used to help Siri and dictation … understand you better and recognise what you say”.

But the company does not explicitly state that that work is undertaken by humans who listen to the pseudonymised recordings.


And another signal of a very possible future.
the level of data consumption needed for microphone surveillance would make the technique not only improbable to execute, but also virtually impossible to hide.
“There were no audio leaks at all – not a single app activated the microphone,” says Christo Wilson, a computer scientist working on the project. “Then we started seeing things we didn’t expect. Apps were automatically taking screenshots of themselves and sending them to third parties. In one case, the app took video of the screen activity and sent that information to a third party.”
Out of over 17,000 Android apps examined, more than 9,000 had potential permissions to take screenshots. And a number of apps were found to actively be doing so, taking screenshots and sending them to third party sources.

Facebook isn’t secretly listening to your conversations, but the truth is much more disturbing

How does Facebook occasionally deliver such disconcertingly timed advertisements? Is it really listening to users through their smartphone microphones? Or is the truth much more unsettling?
Perhaps one of the most pervasive longstanding technology conspiracy theories is that your smartphone is constantly listening in on your private conversations. Almost everyone at some point has felt the eerie synchronicity of seeing an ad served up on Facebook that exactly corresponds to a recent conversation. It’s certainly unnerving, and the most simple explanation is one of direct surveillance. Of course Facebook is listening in on your private conversation with friends, catching key words, and then serving you tailored advertisements. And of course Facebook would deny this is happening.

The problem is, outside of anecdotal cases, no one has ever been able to find clear evidence that this is actually happening. Mobile cybersecurity company Wandera recently conducted a series of experiments which again prove your smartphone is not consistently listening in to your private conversations. So, while this urban myth has again been debunked, the truth about how companies like Facebook sometimes serve up such disturbingly accurate advertisements turns out to be much more complex, and unsettling.

“The harsh truth is that Facebook doesn’t need to perform technical miracles to target you via weak signals. It’s got much better ways to do so already,” writes Garcia-Martinez. “Not every spookily accurate ad you see is a pure figment of your cognitive biases. Remember, Facebook can find you on whatever device you’ve ever checked Facebook on. It can exploit everything that retailers know about you, and even sometimes track your in-store, cash-only purchases; that loyalty discount card is tied to a phone number or email for a reason.”


As light as the clouds? A 3 min video.

How much does a cloud weigh?

Imagine 300 midsize cars floating above your head—that's how much your average fluffy cloud weighs.
So why doesn't it come crashing down on you?

Thursday, September 5, 2019

Friday Thinking 6 Sept 2019

Friday Thinking is a humble curation of my foraging in the digital environment. My purpose is to pick interesting pieces, based on my own curiosity (and the curiosity of the many interesting people I follow), about developments in some key domains (work, organization, social-economy, intelligence, domestication of DNA, energy, etc.)  that suggest we are in the midst of a change in the conditions of change - a phase-transition. That tomorrow will be radically unlike yesterday.

Many thanks to those who enjoy this.

In the 21st Century curiosity will SKILL the cat.

Jobs are dying - Work is just beginning.
Work that engages our whole self becomes play that works.
Techne = Knowledge-as-Know-How :: Technology = Embodied Know-How  
In the 21st century - the planet is the little school house in the galaxy.
Citizenship is the battlefield of the 21st  Century

“Be careful what you ‘insta-google-tweet-face’”
Woody Harrelson - Triple 9


Content
Quotes:


Articles:




the revelation that the unseen underground world is just as complex, sophisticated and purposeful as the visible aboveground world we inhabit. Microbes are not simple, passive accessories to plants, but dynamic, powerful actors in their own right. Fungi can hoard nutrients, they can reward plants that are generous with their carbon reserves and punish ones that are stingy, and they can deftly move and trade resources to get the best “deal” for themselves in exchange.


fungi might not be just nutrient traders but also sophisticated information processors.

Soil’s Microbial Market Shows the Ruthless Side of Forests



What’s universal is danger, not fear. Because danger has to be important in the life of every human, no matter what culture they’re in, they’re going to have a system for understanding that within their culture. They’re going to have a word for it or some words for it. We have 36 words in our language for variations of fear and anxiety. So the experience that’s going to arise is going to be culturally determined and is going to be personally determined.


So what, then, is an emotion?
It’s a conscious awareness that something psychologically or biologically important is happening to you. Evolution gave us these behavioral responses to stimulus, but those are not yet emotions.


A good example of an exaptation is that feathers originally arose in bird-like reptiles for warmth, but then they were co-opted for flight in the wings.


How are emotions exaptations?
I see emotions as the result of other exaptations. One is language. We had certain kinds of communicative skills, and we put these together with other capacities, such as hierarchical relational reasoning, the ability to do mental time travel, to project yourself into the past and the future.

Human Emotions Are Personal Narratives



Every scientist is also a layperson, and brings everyday assumptions into the lab. We study psychological processes because we have psychological experiences, and want to know more about them. But in order to understand psychological experiences scientifically we have to go beyond mere intuitions and analogies and do research to uncover how things actually work.


The philosopher Bertrand Russell once noted, “All the animals that have been carefully observed have behaved so as to confirm the philosophy in which the observer believed before his observations began.”

The Tricky Problem with Other Minds




This is an important signal speaking of the unprecedented change in the human age pyramid. This is a vital driver of new medical inventions, restorative and enhancement technologies and more. Other serious implications concern how we will educate and enable a smaller proportion of youth to become the scientists, engineers, professionals, and more that will be necessary for continued human adaptability.

Anti-ageing drugs are coming – an expert explains

There will be almost ten billion people living on Earth by 2050 and two billion of them will be over the age of 60. 
Growing old is the primary risk factor for multiple chronic and life threatening conditions such as diabetes or cardiovascular disease. This burdensome morbidity is the most distressing aspect of old age – compromising individual independence and straining collective healthcare systems.


To help older people flourish, we must understand the biology of ageing at the tissue, cellular and molecular levels, and then turn that understanding into new preventative medicines. Indeed, it was recently suggested that an “anti-ageing pill” is just around the corner, enabling humans to live to 150 and regenerate organs by 2020 very cheaply. But how excited should we be about such claims? Let’s take a look at the evidence.

This is a good signal of the unprecedented shift in the human age pyramid - Boomers may continue to dominate consumer economies.
“At retirement communities these days, technology is no longer a selling point, it’s an expectation,” says Davis Park, executive director of the Center for Innovation and Wellbeing at Front Porch, a not-for-profit company that manages 12 retirement communities nationwide.

10,000 baby boomers turn 65 in the US every day – can Silicon Valley help with 'happier ageing'?

Companies are creating new devices and apps to mine seniors’ golden years and address the challenges of growing older
Now comes technology’s final frontier: old age. Tech that’s specifically designed for seniors is a growing market, fueled by inexorable demographic trends – about 10,000 baby boomers turn 65 every day.


Senior tech is increasingly showing up in assisted living facilities and nursing homes. A company called It’s Never Too Late proffers a massive 70in high-definition touchscreen computer that provides older people with little prior tech experience easy access to everything from travel videos and music playlists to a library of college lectures. Paro, a robotic seal stuffed with sensors and actuators that react to voice, light and touch, is being used to help those experiencing memory loss and social withdrawal. A movie system called 3Scape provides immersive 3D filmed content for the elderly and mobility-challenged in order to stimulate cognitive function and relieve depression and anxiety.

This shouldn’t be real news - but it is interesting how much more diverse the genetic base of humans are. The next decades will bring a lot more knowledge to the mosaic that we are.
Humans have been continuously evolving through the mixing of varied populations for hundreds of thousands of years. (In fact, Scally posits that our species did not originally evolve from a single population in Africa, but rather from many interconnected populations spread out across the continent.)

Fossil DNA Reveals New Twists in Modern Human Origins

Modern humans and more ancient hominins interbred many times throughout Eurasia and Africa, and the genetic flow went both ways.
Humans today are mosaics, our genomes rich tapestries of interwoven ancestries. With every fossil discovered, with every DNA analysis performed, the story gets more complex: We, the sole survivors of the genus Homo, harbor genetic fragments from other closely related but long-extinct lineages. Modern humans are the products of a sprawling history of shifts and dispersals, separations and reunions — a history characterized by far more diversity, movement and mixture than seemed imaginable a mere decade ago.


But it’s one thing to say that Neanderthals interbred with the ancestors of modern Europeans, or that the recently discovered Denisovans interbred with some older mystery group, or that they all interbred with each other. It’s another to provide concrete details about when and where those couplings occurred. “We’ve got this picture where these events are happening all over the place,” said Aylwyn Scally, an evolutionary geneticist at the University of Cambridge. “But it’s very hard for us to pin down any particular single event and say, yeah, we’re really confident that that one happened — unless we have ancient DNA.”

This is an important signal that shouldn’t be a surprise - but will increase the research into biosynthetics for all manner of uses.
Part of the appeal of ditching greenhouses for bioreactors boils down to cost. Currently, 1 kilogram of high-quality CBD extracted from plants sells for a wholesale price of more than $5,000. A deal in 2018 between Ginkgo Bioworks, a synthetic-biology company in Boston, Massachusetts, and Cronos Group, a Toronto-based cannabis producer, outlines a plan to manufacture pure CBD and other cannabinoids for less than $1,000 per kg in yeast.
“People are so focused on the big two — THC and CBD — that we’re sort of forgetting that there are potentially other really useful compounds in the plant,” says Tony Farina, chief scientific officer at synthetic biology company Librede in Carlsbad, California. “That’s the direction for which we should really be using this biosynthesis platform.”

The bioengineering of cannabis

Genetic modification could enable industrial-scale production of cannabinoids that have pharmaceutical potential.
Cannabis is the only plant known to produce tetrahydrocannabinol (THC), but it remains an imperfect vessel for producing the chemical on an industrial scale. The psychoactive substance is normally found only in small outgrowths from the plant known as trichomes, which means that its stalk, stems and leaves are wasted biomass.


Genetic engineering could provide more efficient alternatives. Some researchers and biotechnology companies are aspiring to replace cannabis plants with microorganisms that have been genetically enhanced to spit out THC, the non–psychoactive compound cannabidiol (CBD) and myriad other cannabinoids of pharmaceutical interest. Others are aiming to modify chemical synthesis in the cannabis plant by genetically altering its cells to make the desired molecules from shoot to tip, thereby boosting yield.


Either way, the goal is the same: to produce cannabinoids more cheaply, efficiently and reliably than by conventional plant cultivation in greenhouses or farmers’ fields. Further benefits of microbial synthesis include the ability to mass-produce rare cannabinoids that are usually present in plants in only trace amounts — or even molecules not found in nature. Transgenic plants can also be engineered for superior resistance to pests and environmental stresses.


Commercial interest in these strategies is picking up. In 2018, for example, Canopy Growth Corporation in Smiths Falls, Canada — the largest legal cannabis company in the world — paid more than US$300 million in cash and shares to acquire Ebbu, a small company in Evergreen, Colorado, that had developed one of the earliest platforms for manipulating the cannabis genome with the gene-editing system CRISPR–Cas9. And in April, Zenabis, a cannabis producer based in Vancouver, Canada, agreed to purchase 36 tonnes of almost-pure, bacterial-made CBD from medical-cannabis company Farmako in Frankfurt, Germany — the first deal of its kind for biosynthetic cannabinoids.

This is an amazing signal of the progress being made via the domestication of DNA.

Woman is first to receive cornea made from ‘reprogrammed’ stem cells

The Japanese woman’s vision has improved since the transplant, say her doctors.
A Japanese woman in her forties has become the first person in the world to have her cornea repaired using reprogrammed stem cells.


At a press conference on 29 August, ophthalmologist Kohji Nishida from Osaka University, Japan, said the woman has a disease in which the stem cells that repair the cornea, a transparent layer that covers and protects the eye, are lost. The condition makes vision blurry and can lead to blindness.


To treat the woman, Nishida says his team created sheets of corneal cells from induced pluripotent stem (iPS) cells. These are made by reprogramming adult skin cells from a donor into an embryonic-like state from which they can transform into other cell types, such as corneal cells.


Japan has been ahead of the curve in approving the clinical use of iPS cells, which were discovered by stem-cell biologist Shinya Yamanaka at Kyoto University, who won a Nobel prize for the work. Japanese physicians have also used iPS cells to treat spinal cord injury, Parkinson’s disease and another eye disease.

This signals progress in our understanding of the importance and impact of our microbial ecology.

A comprehensive catalogue of human digestive tract bacteria

The human digestive tract is home to thousands of different strains of bacteria. Many of these are beneficial, while others contribute to health problems such as inflammatory bowel disease. Researchers from MIT and the Broad Institute have now isolated and preserved samples of nearly 8,000 of these strains, while also clarifying their genetic and metabolic context.
This data set (BIO-ML), which is available to other researchers who want to use it, should help to shed light on the dynamics of microbial populations in the human gut and may help scientists develop new treatments for a variety of diseases, says Eric Alm, director of MIT's Center for Microbiome Informatics and Therapeutics and a professor of biological engineering and of civil and environmental engineering at MIT.


Humans have trillions of bacterial cells in their digestive tracts, and while scientists believe that these populations change and evolve over time, there has been little opportunity to observe this. Through the OpenBiome organization, which collects stool samples for research and therapeutic purposes, Alm and his colleagues at MIT and the Broad Institute had access to fecal samples from about 90 people.

A stronger signalling of the role of AI in accelerating human efforts to research and innovate - transformation of science.

An AI system identified a potential new drug in just 46 days

The approach is based on two popular AI techniques: generative adversarial networks and reinforcement learning.
A team from AI pharma startup Insilico Medicine, working with researchers at the University of Toronto, took 21 days to create 30,000 designs for molecules that target a protein linked with fibrosis (tissue scarring). They synthesized six of these molecules in the lab and then tested two in cells; the most promising one was tested in mice. The researchers concluded it was potent against the protein and showed “drug-like” qualities. All in all, the process took just 46 days. The research was published in Nature Biotechnology this week.


The system examines previous research and patents for molecules known to work against the drug target, prioritizing new structures that could be synthesized in the lab. It’s similar to what a human chemist might do to seek new therapies—just much faster.


Getting a new drug to market is hugely costly and time consuming: it can take 10 years and cost as much as $2.6 billion, with the vast majority of candidates failing at the testing stage, according to the Tufts Center for the Study of Drug Development. No wonder, then, that there’s so much work under way on using AI to expedite the process. DeepMind is among the companies exploring pharmaceutical research as a potential avenue for its algorithms.

This is an interesting signal of the potential for AI to enable Avatar’s (robotic or virtual) to provide counselling and inspiration for spiritual, emotional, psychological assistance.
Developed at a cost of almost US$1 million (S$1.38 million) in a joint project between the Zen temple and renowned robotics professor Hiroshi Ishiguro at Osaka University, the humanoid - called Mindar - teaches about compassion and of the dangers of desire, anger and ego.

Buddhist temple in Japan puts faith in robot priest

A 400-year-old temple in Japan is attempting to hot-wire interest in Buddhism with a robotic priest that it believes will change the face of the religion despite critics comparing the android to "Frankenstein's monster".


The android Kannon, based on the Buddhist deity of mercy, preaches sermons at Kodaiji temple in Kyoto, and its human colleagues predict that with artificial intelligence (AI), it could one day acquire unlimited wisdom.
"This robot will never die, it will just keep updating itself and evolving," priest Tensho Goto told Agence France-Presse.


"That's the beauty of a robot. It can store knowledge forever and limitlessly. With AI, we hope it will grow in wisdom to help people overcome even the most difficult troubles. It's changing Buddhism," added Mr Goto.


The adult-sized robot was put into service earlier this year and is able to move its torso, arms and head. But only its hands, face and shoulders are covered in silicone to replicate human skin.


From smart toilets to virtual assistants
No area of life is safe from being disrupted by technology, not even the bathroom. The TrueLoo “smart toilet” optically scans and analyzes the contents of a toilet bowl to detect signs of dehydration, viruses and urinary tract infections. The TrueLoo is currently being tested at several northern California senior living communities and has secured a round of venture capital funding before it even hits the market.

I’m sure the porn industry has already reversed engineered this app or is in the process. A whole new Hollywood industry could arise everyone could actually be on the big screen - mass customized viewer cuts … So much more.

Chinese deepfake app Zao sparks privacy row after going viral

Critics say face-swap app could spread misinformation on a massive scale
A Chinese app that lets users convincingly swap their faces with film or TV characters has rapidly become one of the country’s most downloaded apps, triggering a privacy row.


Released on Friday, the Zao app went viral as Chinese users seized on the chance to see themselves act out scenes from well-known movies using deepfake technology, which has already prompted concerns elsewhere over potential misuse.


Users provide a series of selfies in which they blink, move their mouths and make facial expressions, which the app uses to realistically morph the person’s animated likeness on to movies, TV shows or other content.



Now here is another medical bot signaling new medical procedures for a range of problems - and who knows what affordances others will find to put it to even other weird uses. The 3 min video and other graphics provide clear visuals for understanding.

MIT Researchers Designed this Robotic Worm to Burrow Into Human Brains

Robotics engineers at MIT have built a threadlike robot worm that can be magnetically steered to deftly navigate the extremely narrow and winding arterial pathways of the human brain. One day it could be used to quickly clear blockages and clots that contribute to strokes and aneurysms, while at the same time making the current state of robotic evolution even more unsettling.


Strokes are a leading cause of death and disability in the United States, but relieving blood vessel blockages within the first 90 minutes of treatment has been found to dramatically increase survival rates of patients. The process is a complicated one, however, requiring skilled surgeons to manually guide a thin wire through a patient’s arteries up into a damaged brain vessel followed by a catheter that can deliver treatments or simply retrieve a clot. Not only is there the potential for these wires to damage vessel linings as they inch through the body, but during the process, surgeons are exposed to excess radiation from a fluoroscope which guides them by generating x-ray images in real-time. There’s a lot of room for improvement.

This article is a little old - but it does signal positive news of human action that could help mitigate Climate Change.

Human Activity in China and India Dominates the Greening of Earth, NASA Study Shows

The world is literally a greener place than it was 20 years ago, and data from NASA satellites has revealed a counterintuitive source for much of this new foliage: China and India. A new study shows that the two emerging countries with the world’s biggest populations are leading the increase in greening on land. The effect stems mainly from ambitious tree planting programs in China and intensive agriculture in both countries.


The greening phenomenon was first detected using satellite data in the mid-1990s by Ranga Myneni of Boston University and colleagues, but they did not know whether human activity was one of its chief, direct causes. This new insight was made possible by a nearly 20-year-long data record from a NASA instrument orbiting the Earth on two satellites. It’s called the Moderate Resolution Imaging Spectroradiometer, or MODIS, and its high-resolution data provides very accurate information, helping researchers work out details of what’s happening with Earth’s vegetation, down to the level of 500 meters, or about 1,600 feet, on the ground.


Taken all together, the greening of the planet over the last two decades represents an increase in leaf area on plants and trees equivalent to the area covered by all the Amazon rainforests. There are now more than two million square miles of extra green leaf area per year, compared to the early 2000s – a 5% increase.

This is a good discussion of the inevitable problem of presenting ‘real’ facts that include the inherent uncertainties in all science research results.

How to Get Better at Embracing Unknowns

Interpreting uncertainty through data visualizations
When tracking a hurricane, forecasters often show a map depicting a “cone of uncertainty.” It starts as a point—the hurricane's current position—and widens into a swath of territory the storm might cross in the upcoming days. The most likely path is along the centerline of the cone, with the probability falling off toward the edges. The problem: many people misinterpret the cone as the size of the future storm.


Researchers have found that the misunderstanding can be prevented if forecasters instead show a number of possible paths. Yet this approach can also introduce misunderstanding: lots of people think the probability of damage is greater where each path intersects land and less likely between the lines (maps).

I have often proposed that optimism is the most pragmatic orientation human can take. Who would have kids, take on a mortgage, engage in years long studies to commit to an occupation - unless they were optimistic. This is some small confirmation of other benefits of optimism.
"Resilience is our ability to bounce back, to recover," she says. "And what this study shows is that optimism actually plays a very big role in our ability to bounce — even if we experience setbacks."

Optimists For The Win: Finding The Bright Side Might Help You Live Longer

Good news for the cheery: A Boston study published this month suggests people who tend to be optimistic are likelier than others to live to be 85 years old or more.
That finding was independent of other factors thought to influence life's length — such as "socioeconomic status, health conditions, depression, social integration, and health behaviors," the researchers from Boston University School of Medicine and the Harvard T.H. Chan School of Public Health say. Their work appears in a recent issue of the science journal PNAS.


Researchers already knew from previous work that optimistic individuals tend to have a reduced risk of depression, heart disease and other chronic diseases. But might optimism also be linked to exceptional longevity? Lee looked at medical records from two long term research studies — one involving female nurses and the other involving men, mostly veterans.


The study included 69,744 women and 1,429 men. Both groups completed survey measures to assess their level of optimism, as well as their overall health and health habits such as diet, smoking and alcohol use. In the survey, study participants were asked if they agreed with statements such as "in uncertain times I usually expect the best" or "I usually expect to succeed in things that I do."


Health outcomes from women in the study were tracked for 10 years, while the men's health was followed for 30 years. Researchers found that the most optimistic men and women demonstrated, on average, an 11-15% longer lifespan, and had far greater odds of reaching 85 years old, compared to the least optimistic group.